• Drug Metab Dispos. 2021; In press. Alterations of cytochrome P450-mediated drug metabolism during liver repair and regeneration after acetaminophen-induced liver injury in mice. Bao Y, Phan M, Zhu J, Ma X, Manautou JE, Zhong XB. PubMed
  • FASEB J. 2021;35:e21304. Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes. Donepudi AC, Lee Y, Lee JY, Schuetz JD, Manautou JE. PubMed
  • Toxicol Sci. 2020;175:301-311. Lack of Multidrug Resistance-associated Protein 4 prolongs partial hepatectomy-induced hepatic steatosis. Donepudi AC, Smith GJ, Aladelokun O, Lee Y, Toro SJ, Pfohl M, Slitt AL, Wang L, Lee JY, Schuetz JD, Manautou JE. PubMed
  • Drug Metab Dispos. 2020;48:326-336. Acetaminophen-induced liver injury alters expression and activities of Cytochrome P450 enzymes in an age-dependent manner in mouse liver. Bao Y, Wang P, Shao X, Zhu J, Xiao J, Shi J, Zhang L, Zhu HJ, Ma X, Manautou JE, Zhong XB. PubMed
  • Drug Metab Dispos. 2019;47:1080-1092. Identification and characterization of efflux transporters that modulate the subtoxic Ddsposition of Diclofenac and its metabolites. Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE. PubMed
  • Acta Pharm Sin B. 2019;9:659-674. Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2. Chen L, Manautou JE, Rasmussen TP, Zhong XB. PubMed
  • Curr Med Chem. 2019;26:1185-1223. Modulation of hepatic MRP3/ABCC3 by xenobiotics and pathophysiological conditions: Role in drug pharmacokinetics. Ghanem CI, Manautou JE. PubMed
  • Toxicology. 2017;386:84-92. Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus. Flores K, Manautou JE, Renfro JL. PubMed
  • F1000Res. 2016;5:F1000. From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective. Rudraiah S, Manautou JE. PubMed
  • Drug Metab Dispos. 2015;43:944-50. Multidrug Resistance-Associated Protein 3 plays an important role in protection against acute toxicity of Diclofenac. Scialis RJ, Csanaky IL, Goedken MJ, Manautou JE. PubMed
  • Am J Pathol. 2014;184:1299-308. Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice. Wen X, Buckley B, McCandlish E, Goedken MJ, Syed S, Pelis R, Manautou JE, Aleksunes LM. PubMed
  • Expert Rev Mol Med. 2012 Feb 3;14:e4. Molecular mechanisms underlying chemical liver injury. Gu X, Manautou JE. PubMed
  • J Biochem Mol Toxicol. 2011;25:320-9. Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1. Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL. PubMed
  • Drug Metab Rev. 2010;42:482-538. Regulation of hepatic ABCC transporters by xenobiotics and in disease states. Gu X, Manautou JE. PubMed
  • Toxicol Appl Pharmacol. 2009;236:49-58. Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function. Campion SN, Tatis-Rios C, Augustine LM, Goedken MJ, van Rooijen N, Cherrington NJ, Manautou JE. PubMed
  • Toxicol Sci. 2008;106:319-28. Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Maher JM, Aleksunes LM, Dieter MZ, Tanaka Y, Peters JM, Manautou JE, Klaassen CD. PubMed
  • Toxicology. 2008;250:82-8. Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment. Aleksunes LM, Augustine LM, Scheffer GL, Cherrington NJ, Manautou JE. PubMed
  • Am J Physiol Gastrointest Liver Physiol. 2008;295:G294-304. Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. Campion SN, Johnson R, Aleksunes LM, Goedken MJ, van Rooijen N, Scheffer GL, Cherrington NJ, Manautou JE. PubMed
  • Mol Pharm. 2008;5:77-91. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Cheng Q, Aleksunes LM, Manautou JE, Cherrington NJ, Scheffer GL, Yamasaki H, Slitt AL. PubMed
  • Drug Metab Lett. 2008;2:11-7. Renal and hepatic transporter expression in type 2 diabetic rats. Nowicki MT, Aleksunes LM, Sawant SP, Dnyanmote AV, Mehendale HM, Manautou JE. PubMed
  • Toxicol Appl Pharmacol. 2008;226:74-83. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE. PubMed
  • J Toxicol Environ Health A. 2007;70:1870-2. Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity. Aleksunes LM, Augustine LM, Cherrington NJ, Manautou JE. PubMed
  • Hepatology. 2007;46:1597-610. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. PubMed
  • Drug Metab Dispos. 2007;35:1970-8. Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Lickteig AJ, Fisher CD, Augustine LM, Aleksunes LM, Besselsen DG, Slitt AL, Manautou JE, Cherrington NJ. PubMed
  • Drug Metab Dispos. 2007;35:1963-9. Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases. Barnes SN, Aleksunes LM, Augustine L, Scheffer GL, Goedken MJ, Jakowski AB, Pruimboom-Brees IM, Cherrington NJ, Manautou JE. PubMed
  • Biochim Biophys Acta. 2007;1768:637-47. Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Slitt AL, Allen K, Morrone J, Aleksunes LM, Chen C, Maher JM, Manautou JE, Cherrington NJ, Klaassen CD. PubMed
  • J Pharmacol Exp Ther. 2006;317:537-45. Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. Moffit JS, Aleksunes LM, Maher JM, Scheffer GL, Klaassen CD, Manautou JE. PubMed
  • Biochem Pharmacol. 2005;70:1832-9. Transport deficient (TR-) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity. Silva VM, Thibodeau MS, Chen C, Manautou JE. PubMed
  • Hepatology. 2005;42:1091-8. Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Manautou JE, de Waart DR, Kunne C, Zelcer N, Goedken M, Borst P, Elferink RO. PubMed
  • Toxicol Sci. 2006;89:370-9. Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury. Aleksunes LM, Scheffer GL, Jakowski AB, Pruimboom-Brees IM, Manautou JE. PubMed
  • Toxicol Sci. 2005;83:44-52. Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Aleksunes LM, Slitt AM, Cherrington NJ, Thibodeau MS, Klaassen CD, Manautou JE. PubMed
  • Drug Metab Dispos. 2003;31:798-804. Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats. Chen C, Hennig GE, Manautou JE. PubMed


Storrs, United States


Last update: October 2021