PHARMACOLOGY

Peter MEIER-ABT

J Public Health Policy. 2014;35:420-1. The Meikirch model of health fits well into the concept of 'personalized health'. Meier-Abt PJ. PubMed

Pflugers Arch. 2015;467:1481-93. Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS. Gao B, Vavricka SR, Meier PJ, Stieger B. PubMed

Pharmacogenomics. 2011;12:611-31. Pharmacogenetics of drug transporters in the enterohepatic circulation. Stieger B, Meier PJ. PubMed

Semin Liver Dis. 2010;30:147-59. Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. Pauli-Magnus C, Meier PJ, Stieger B. PubMed

Hepatology. 2009;49:1673-82. ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes. Ismair MG, Häusler S, Stuermer CA, Guyot C, Meier PJ, Roth J, Stieger B. PubMed

Am J Physiol Cell Physiol. 2009;296:C570-82. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Leuthold S, Hagenbuch B, Mohebbi N, Wagner CA, Meier PJ, Stieger B. PubMed

World J Gastroenterol. 2008;14:38-45. Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. Meier Y, Zodan T, Lang C, Zimmermann R, Kullak-Ublick GA, Meier PJ, Stieger B, Pauli-Magnus C. PubMed

Pharmacogenet Genomics. 2007;17:47-60. Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C. PubMed

Hepatology. 2007;45:150-8. Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. Schneider G, Paus TC, Kullak-Ublick GA, Meier PJ, Wienker TF, Lang T, van de Vondel P, Sauerbruch T, Reichel C. PubMed

Pflugers Arch. 2007;453:611-20. The bile salt export pump. Stieger B, Meier Y, Meier PJ. PubMed

Hepatology. 2006;44:778-87. Hepatobiliary transporters and drug-induced cholestasis. Pauli-Magnus C, Meier PJ. PubMed

Am J Physiol Cell Physiol. 2007;292:C795-806. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B. PubMed

Hepatology. 2006 Jul;44:62-74. Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Meier Y, Pauli-Magnus C, Zanger UM, Klein K, Schaeffeler E, Nussler AK, Nussler N, Eichelbaum M, Meier PJ, Stieger B. PubMed

Mol Pharmacol. 2006;70:806-17. Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Hänggi E, Grundschober AF, Leuthold S, Meier PJ, St-Pierre MV. PubMed

Methods Enzymol. 2005;400:511-30. Coordinate transcriptional regulation of transport and metabolism. Eloranta JJ, Meier PJ, Kullak-Ublick GA. PubMed

J Hepatol. 2005;43:536-43. Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. Noe J, Kullak-Ublick GA, Jochum W, Stieger B, Kerb R, Haberl M, Müllhaupt B, Meier PJ, Pauli-Magnus C. PubMed

Invest Radiol. 2005;40:187-94. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp C, Montet X, Frossard JL, Quadri R, Stieger B, Meier PJ, Ivancevic MK, Vallée JP, Terrier F, Pastor CM. PubMed

J Clin Gastroenterol. 2005;39:S103-10. Hepatocellular transporters and cholestasis. Pauli-Magnus C, Meier PJ. PubMed

Toxicol Appl Pharmacol. 2005;203:257-63. Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B. PubMed

Mol Pharmacol. 2005;67:1629-38. The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids. Popowski K, Eloranta JJ, Saborowski M, Fried M, Meier PJ, Kullak-Ublick GA. PubMed

Am J Physiol Gastrointest Liver Physiol. 2005;288:G771-8. Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver. Frei P, Gao B, Hagenbuch B, Mate A, Biber J, Murer H, Meier PJ, Stieger B. PubMed

Am J Physiol Gastrointest Liver Physiol. 2005;288:G159-67. Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y. PubMed

Am J Physiol Regul Integr Comp Physiol. 2004;287:R1505-16. Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat. St-Pierre MV, Stallmach T, Freimoser Grundschober A, Dufour JF, Serrano MA, Marin JJ, Sugiyama Y, Meier PJ. PubMed

Mol Pharmacol. 2004;66:450-9. Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2. Sasaki M, Suzuki H, Aoki J, Ito K, Meier PJ, Sugiyama Y. PubMed

Pharm Res. 2004;21:1294-302. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. PubMed

J Hepatol. 2004;41(2):201-8. Differential expression of bile salt and organic anion transporters in developing rat liver. Gao B, St Pierre MV, Stieger B, Meier PJ. PubMed

J Cell Sci. 2004 Aug;117(Pt 18):4077-87. Small hepatocytes in culture develop polarized transporter expression and differentiation. Sidler Pfändler MA, Höchli M, Inderbitzin D, Meier PJ, Stieger B. PubMed

Drug Metab Dispos. 2004;32:834-9. Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes. Turncliff RZ, Meier PJ, Brouwer KL. PubMed

Invest Radiol. 2004;39:506-15. Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactor. Planchamp C, Gex-Fabry M, Dornier C, Quadri R, Reist M, Ivancevic MK, Vallée JP, Pochon S, Terrier F, Balant L, Stieger B, Meier PJ, Pastor CM. PubMed

Pharmacogenetics. 2004;14:91-102. Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA. PubMed

Hepatology. 2004 Mar;39:779-91. BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. Pauli-Magnus C, Kerb R, Fattinger K, Lang T, Anwald B, Kullak-Ublick GA, Beuers U, Meier PJ. PubMed

J Hepatol. 2004;40:212-8. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. Vavricka SR, Jung D, Fried M, Grützner U, Meier PJ, Kullak-Ublick GA. PubMed

Am J Physiol Gastrointest Liver Physiol. 2004;286:G752-61. Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene. Jung D, Hagenbuch B, Fried M, Meier PJ, Kullak-Ublick GA. PubMed

Gastroenterology. 2004;126:322-42.Enterohepatic bile salt transporters in normal physiology and liver disease. Kullak-Ublick GA, Stieger B, Meier PJ. PubMed

J Hepatol. 2003;39:1095-7. Fatal liver failure with atorvastatin. Perger L, Kohler M, Fattinger K, Flury R, Meier PJ, Pauli-Magnus C. PubMed

Pflugers Arch. 2004;447:653-65. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Hagenbuch B, Meier PJ. PubMed

Hepatol Res. 2003;26:343-347. Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. Ismair MG, Stanca C, Ha HR, Renner EL, Meier PJ, Kullak-Ublick GA. PubMed

Hepatology. 2003;38:187-95. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate. Rost D, Herrmann T, Sauer P, Schmidts HL, Stieger B, Meier PJ, Stremmel W, Stiehl A. PubMed

Mol Pharmacol. 2003 Jul;64:154-9. Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions. Patel NJ, Zamek-Gliszczynski MJ, Zhang P, Han YH, Jansen PL, Meier PJ, Stieger B, Brouwer KL. PubMed

Curr Drug Metab. 2003;4:185-211. Drug uptake systems in liver and kidney. van Montfoort JE, Hagenbuch B, Groothuis GM, Koepsell H, Meier PJ, Meijer DK. PubMed

Pharmacogenetics. 2003;13:189-98. Pharmacogenetics of hepatocellular transporters. Pauli-Magnus C, Meier PJ. PubMed

Biochim Biophys Acta. 2003;1609:87-94. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Geier A, Dietrich CG, Gerloff T, Haendly J, Kullak-Ublick GA, Stieger B, Meier PJ, Matern S, Gartung C. PubMed