Christelle Borel, PhD


Country of origin: France

Academic degrees: BS in Molecular and Cellular Biology, Claude Bernard University of Lyon, France.

                         MS in Biochemistry, Claude Bernard University of Lyon, France.

                           PhD in Virology, Claude Bernard University of Lyon, France.

Position in the lab: Biologist, senior scientist.

Current research interest: whole genome/transcriptome of a single cell using next-generation sequencing technology.

Selection of peer-reviewed publications (*equal contribution):

-Borel C., Cheung F., Stewart H., Koolen D.A, Phillips C., Thomas N.S., Jacobs P.A., Eliez S., Sharp A.J. Evaluation of PRDM9 variation as a risk factor for recurrent genomic disorders and chromosomal non-disjunction. Human Genetics. 2012. 131(9):1519-24.

-Borel C., Migliavacca E., Letourneau A., Gagnebin M., Béna F., Sailani M. R., Emmanouil T. Dermitzakis E.T., Andrew J. Sharp A.J.,  Antonarakis S.E. Tandem repeat sequence variation as causative cis eQTLs for protein-coding gene expression variation: the case of CSTB. Human Mutation. 2012. 33(8):1302-9.

-ENCODE Project Consortium, Myers R.M., Stamatoyannopoulos J., Snyder M., Dunham I., Hardison R.C., Bernstein B.E., Gingeras T.R., Kent W.J., Birney E., Wold B., Crawford G.E. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biology. 2011. 9(4):e1001046.

-Borel C., Deutsch S., Letourneau A., Migliavacca E., Montgomery S.B., Dimas A.S., Vejnar C.E., Attar H., Gagnebin M., Gehrig C., Falconnet E., Dupré Y., Dermitzakis E.T., Antonarakis S.E. Identification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts. Genome Research. 2011. 21(1):68-73.

-Kapranov P., Ozsolak F., Kim S.W., Foissac S., Lipson D., Hart C., Roels S., Borel C., Antonarakis S.E., Monaghan A.P., John B., Milos P.M. New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism. Nature. 2010. 466(7306):642-6.

-Fort A., Borel C.*, Migliavacca E., Antonarakis S. E., Fish R. J., Neerman-Arbez M.Regulation of Fibrinogen by microRNAs. Blood. 2010 Jun 22.

- Dimas A.S., Deutsch S.*, Stranger B.E.*, Montgomery S.B.*, Borel C., Attar-Cohen H., Ingle C., Beazley C., Arcelus M.G., Sekowska M., Gagnebin M., Nisbett J., Deloukas P., Dermitzakis E.T., Antonarakis S.E. Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner. Science. 2009. 325(5945):1246-50.

-Borel C., Antonarakis S. E. Functional genetic variation of human miRNAs and phenotypic consequences. Mammalian Genome. 2008. 19 : 503-9.

-Borel C., Gagnebin M., Gehrig C., Kriventseva E.V., Zdobnov E.M., Antonarakis S.E. Mapping of small RNAs in the human ENCODE regions. American Journal of Human Genetics. 2008. 82: 971-81.

-Sethupathy P., Borel C.*, Gagnebin M., Grant G.R., Deutsch S., Elton T.S., Hatzigeorgiou A.G., Antonarakis, S.E. Human Microrna-155 On Chromosome 21 Differentially Interacts With Its Polymorphic Target In The AGTR1 3' Untranslated Region: A Mechanism For Functional Single-Nucleotide Polymorphisms Related To Phenotypes. American Journal of Human Genetics. 2007. 81: 405-13.

-Faure J., Stalder R. and Borel C.*, Sobo K., Piguet V., Demaurex N., Trono D. and Gruenberg J. ARF1 Regulates Nef-Induced CD4 Degradation. Current Biology. 2004. 14(12):1056-64.

-Piguet V., Wan L., Borel C., Mangasarian A., Demaurex N., Thomas G., Trono D. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nature Cell Biology. 2000. 2(3):163-7.

-Borel C., Sunyach C., Hantz O., Trepo C. and Kay A. Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle. Virology. 1998. 242 : 90-98.