Federico Andrea Santoni, PhD

Country of origin: Sassari, Sardegna, Italy

Academic degrees: BS in Electronic Engineering, Politecnico di Torino, Italy.

                            MS in Electronic Engineering, Politecnico di Torino, Italia.

                            PhD in Bioinformatics, University of Geneva and Swiss Institute of Bioinformatics, Switzerland.

Position in the lab: Computational Biologist/bioinformatician.

Research interests: I'm involved in the development and setup of computational tools for solving biological problems and the analysis of different kinds of data as microarray and RNASeq transcriptomes, Exome sequencing, whole-genome bisulphite sequencing (MethylC-seq), chromatin-immunoprecipitation sequencing (ChIP-Seq) and others. I work in close contact with all the members of the lab.

Publications:

Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011 Apr 21;472(7343):361-5. PubMed PMID: 21512573; PubMed Central PMCID: PMC3081621.

Santoni FA, Hartley O, Luban J. Deciphering the code for retroviral integration target site selection. PLoS Comput Biol. 2010 Nov 24;6(11):e1001008. PubMed PMID: 21124862; PubMed Central PMCID: PMC2991247.

Bortolato M, Frau R, Orrù M, Fà M, Dessì C, Puligheddu M, Barberini L, Pillolla G, Polizzi L, Santoni F, Mereu G, Marrosu F. GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice. Seizure. 2010 May;19(4):226-31. Epub 2010 Mar 15. PubMed PMID: 20233662.

Morelli L, Contu D, Santoni F, Whalen MB, Francalacci P, Cucca F. A comparison of Y-chromosome variation in Sardinia and Anatolia is more consistent with cultural rather than demic diffusion of agriculture. PLoS One. 2010 Apr 29;5(4):e10419. PubMed PMID: 20454687; PubMed Central PMCID: PMC2861676.

Leo, S., Santoni, F. and Zanetti, G. 2009. In The 38th International Conference on Parallel Processing Workshops (ICPPW 2009), Vienna, Austria. IEEE comp. soc., pp. 415-422. Pinto L, Mader MT, Irmler M, Gentilini M, Santoni F, Drechsel D, Blum R, Stahl R, Bulfone A, Malatesta P, Beckers J, Götz M. Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis. Mol Cell Neurosci. 2008 May;38(1):15-42. Epub 2008 Feb 1. PubMed PMID: 18372191.

Pitzalis M, Zavattari P, Murru R, Deidda E, Zoledziewska M, Murru D, Moi L, Motzo C, Orrù V, Costa G, Solla E, Fadda E, Schirru L, Melis MC, Lai M, Mancosu C, Tranquilli S, Cuccu S, Rolesu M, Secci MA, Corongiu D, Contu D, Lampis R, Nucaro A, Pala G, Pacifico A, Maioli M, Frongia P, Chessa M, Ricciardi R, Lostia S, Marinaro AM, Milia AF, Landis N, Zedda MA, Whalen MB, Santoni F, Marrosu MG, Devoto M, Cucca F. Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia. BMC Med Genet. 2008 Jan 20;9:3. PubMed PMID: 18205952; PubMed Central PMCID: PMC2259316.

Contu D, Morelli L, Santoni F, Foster JW, Francalacci P, Cucca F. Y-chromosome based evidence for pre-neolithic origin of the genetically homogeneous but diverse Sardinian population: inference for association scans. PLoS One. 2008 Jan 9;3(1):e1430. PubMed PMID: 18183308; PubMed Central PMCID: PMC2174525.

Marrosu F, Santoni F, Fà M, Puligheddu M, Barberini L, Genugu F, Frau R, Manunta M, Mereu G. Beta and gamma range EEG power-spectrum correlation with spiking discharges in DBA/2J mice absence model: role of GABA receptors. Epilepsia. 2006 Mar;47(3):489-94. PubMed PMID: 16529610.

Marrosu F, Santoni F, Puligheddu M, Barberini L, Maleci A, Ennas F, Mascia M, Zanetti G, Tuveri A, Biggio G. Increase in 20-50 Hz (gamma frequencies) power spectrum and synchronization after chronic vagal nerve stimulation. Clin Neurophysiol. 2005 Sep;116(9):2026-36. PubMed PMID: 16055378.

Lavorgna G, Triunfo R, Santoni F, Orfanelli U, Noci S, Bulfone A, Zanetti G, Casari G. AntiHunter 2.0: increased speed and sensitivity in searching BLAST output for EST antisense transcripts. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W665-8. PubMed PMID: 15980558; PubMed Central PMCID: PMC1160209.