Muscle Stem Cells and Cell Therapy

Our laboratory conducts fundamental and translational research focused on the regulation of human muscle stem cells (MuSCs).

Our team has recognized expertise in the isolation, culture, characterization, and transplantation of human muscle stem cells. Our research is primarily aimed at developing innovative cell-based therapeutic strategies for the treatment of skeletal muscle disorders. We have demonstrated that so-called human reserve muscle cells (MuRCs), generated in vitro, share strong similarities with quiescent MuSCs and possess the properties required for their application in cell therapy. Ongoing studies seek to characterize the molecular signature and metabolic profile of human MuRCs, as well as to identify novel mechanisms involved in the regulation of their function, both in vitro and in vivo.