Prof. Francesco Negro
Virus de l’hépatite et résistance à l’insuline
Francesco Negro earned his MD in 1982 and was board-certified in Gastroenterology at the University of Torino, Italy. He undertook post-doctoral training on hepatitis Delta at the Georgetown University and then at the NIAID, NIH, USA. In Geneva since 1994, he analysed HCV replication at the tissue level, leading to the discovery that HCV genotype 3a causes a particularly severe form of liver steatosis. His current research, supported by the SNF, focuses on the mechanisms leading to steatosis and glucose metabolism alterations in hepatitis C. He has participated in several clinical trials in acute and chronic HCV and is Founder and Chairman of the Swiss Hepatitis C Cohort Study. He is currently Full Professor at the Geneva Faculty of Medicine.
Relationship between hepatitis C virus infection and glucose and lipid metabolism: mechanisms and significance
Prof. Negro's lab study the mechanisms leading to steatosis and insulin resistance in hepatitis C in vitro and in vivo. Concerning the steatosis, they assess the role of lipid droplet-associated proteins in the HCV life cycle, the lipidome profiling of lipid droplets in HCV infection and the relationship between HCV and the tumor suppressor PTEN. Regarding the interference of HCV on the glucose homeostasis, they analyse the relative contribution of liver vs. extrahepatic sites to the overall insulin resistance in HCV infection, both in vitro and in patients treated with antivirals. Finally, they analyse the host factors affecting the pathogenesis of HCV, including host genetic polymorphisms (IL28B, CCR5, SPP1, TM6SF2, PNPLA3, FNDC5) and metabolic alterations, in collaboration with the Swiss Hepatitis C Cohort and other international cohorts.