building a strong network fostering basic and clinical research
In Geneva, many research groups are working on inflammation, and collectively adopt a translational approach. In addition, the proximity of the HUG and the ability to the resulting clinical research allows for the consideration of a potential application, rapid discovery in order to develop new approaches — preventive or therapeutic.
The creation of the Geneva Centre for Inflammation Research, in November 2020, makes it possible to pooling resources, fostering multidisciplinary collaborations and to attract young talent; it will also be offer physicians with state-of-the-art training. In addition, in order to accelerate the rapid translation of research results into medical advances for the population, the Centre will provide an interface between the academic and industrial worlds by supporting the valorization of the work done here. The Centre's research themes are very varied, but can be broadly categorised in three main domains: immune dysfunction, host response to pathogens, and immune cell trafficking and maturation.
What is inflammation?
Inflammation is a reaction of the immune system allowing to fight effectively diseases. But sometimes, inflammation is deregulated and triggers chronic pathologies, such as autoimmune diseases or cancer, or still overreacts in an uncontrolled way to certain pathogens, as in the case of COVID-19. Phenomena related to inflammation can also explain graft rejection or increased susceptibility infections in transplant recipients with a weakened immune system. From many therapeutic strategies target regulation of inflammation: modulation of inflammation in case of arthritis or other inflammatory diseases, cancer immunotherapy or adjuvants that make some vaccines more effective.