Transplantation and Immunology
The research aims of this group is mainly focused on hematopoietic stem cell transplantations and organ transplantations. For the hematopoietic stem cell transplantations, our interest is in the TCR repertoire reconstitution after transplantations and factors that contribute to modulate this repertoire especially infections and any other inflammatory events (GVHD, relapse, ...). The group is also very active in understanding the mechanism of alloreactivity with the analysis of clinical data at the immunogenetics (HLA) level but also by in vitro cellular essay. Finally, the group is active at a more clinical level by analyzing the contribution of anti-HLA antibodies in the complications and graft survival of solid organ transplantations including kidneys, livers and pancreas.
Specific expertise
MHC analysis, immunogenetics, TCR repertoire analysis, translational research with accessibility to sample from human cohorts.
Selected publications
High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation. Buhler S, Baldomero H, Ferrari-Lacraz S, Nunes JM, Sanchez-Mazas A, Massouridi-Levrat S, Heim D, Halter J, Nair G, Chalandon Y, Schanz U, Güngör T, Nicoloso G, Tiercy JM, Passweg J, Villard J. Bone Marrow Transplant. 2019, 54(10):1701-1709
Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation. Stéphane Buhler, Florence Bettens, Carole Dantin, Sylvie Ferrari-Lacraz, Marc Ansari, Anne-Claire Mamez, Stavroula Masouridi-Levrat, Yves Chalandon, Jean Villard. Leukemia. 2020, 34(5):1422-1432
Natural Killer Cell Alloreactivity Against Human Induced Pluripotent Stem Cells and Their Neuronal Derivatives into Dopaminergic Neurons. Casimir de Rham, Zuleika Calderin Sollet, Pierre Burkhard, Jean Villard. Stem Cells Dev. 2020, 1;29(13):853-862
HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation. Petersdorf EW, Stevenson P, Bengtsson M, De Santis D, Dubois V, Gooley T, Horowitz M, Hsu K, Madrigal JA, Malkki M, McKallor C, Morishima Y, Oudshoorn M, Spellman SR, Villard J, Carrington M. Blood. 2020, 16;136(3):362-369
Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation. K Hadaya, C de Rham, C Bandelier, C Bandelier, S Ferrari-Lacraz, S Jendly, T Berney, L Buhler, L Kaiser, J D Seebach, J M Tiercy, P Y Martin, J Villard. Am J Transplant. 2008, 8(12):2674-83
28 Oct 2020