Wu Lab


1.     Wu PH* and Zamore PD*. (2021) To degrade a microRNA, destroy its Argonaute protein. Molecular Cell 81(2), 223–225. *co-corresponding authors. PMID33482091

2.     Wu PH* and Zamore PD*. (2021) Defining the functions of PIWI-interacting RNAs. Nature Reviews Molecular Cell Biology. *co-corresponding authors. PMID33483697

3.     Wu PH*, Fu Y, Cecchini K, Ozata DM, Arif A, Yu T, Colpan C, Gainetdinov I, Weng Z*, Zamore PD*. (2020) The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility. Nature Genetics 52(7):728-739. *co-corresponding authors. PMID32601478

4.     Ozata DM, Yu T, Mou H, Gainetdinov I, Colpan C, Cecchini K, Kaymaz Y, Wu PH, Fan K, Kucukural A,  Weng Z, Zamore PD. (2020) Evolutionarily conserved pachytene piRNA loci are diverging rapidly among modern humans. Nature Ecology and Evolution 4(1):156-168. PMID31900453

5.     Fu Y*, Wu PH*, Beane T, Zamore PD, Weng Z. (2018) Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers. BMC Genomics 13;19(1):531. *co-first authors. PMID30001700

6.     Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. (2018) Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nature Biotechnology 36(9):839-842. PMID30102296

7.     Wu PH, Isaji M, Carthew RW. (2013) Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Molecular Cell 52(1):113-23. PMID24055343

8.     Marques JT, Kim K, Wu PH, Alleyne TM, Jafari M, Carthew RW. (2010) Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. Nature Structural and Molecular Biology 17(1):24-30. PMID20037596

9.     Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. (2005) Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1α. Cell 122(4):505-15. PMID16122419

10.   Arany Z, He H, Lin J, Hoyer K, Handschin C, Doka O, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Ingwall J, Spiegelman BM. (2005) Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism 1(4):259-71. PMID16054070

11.   Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell 120(2):261-73. PMID15680331

12.   Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice. Cell 119(1):121-35. PMID15454086