Prevention of neonatal complications of perinatal origin
Most of research programs developed in this group are focused on perinatal medicine and aim to prevent complications of premature birth or intra-uterine growth retardation. Clinical, translational and pre-clinical research programs are developed into two branches, in Paris and in Geneva with complementary expertises and tools. Students, PhD and Postdoc are welcome at both sites.
A. Clinical research
- Randomized controlled trials, phase 3-4: many perinatal fields with special interest for the brain and lung protection (antenatal corticosteroid therapy, BETADOSE and BETANINO), postnatal corticosteroid therapy (PREMILOC and its ancillary studies), neuroprotection...).
- Phase 1-2 trials in collaboration with industrial partners testing molecules or medical devices of interest in neonatology.
- Cohort studies based on the exploitation database (EPIPAGE 2 in France, SwissNeoNet in Switzerland), in the field of neonatal neurology.
- Research of biomarkers on human biobanks in the case of IUGR and translational validation of pre-clinical markers.
- Analysis of changes in cerebral blood flow by ultra-fast Doppler and correlations to the sleep states in the newborn during brain development
B. preclinical and translational research programmes
These research programmes are jointly developed at Child and Development Lab in Geneva headed by Prof. Petra Hüppi and at Inserm U1141 (PROTECT lab) in Paris (www.neurodiderot.org Team Neurokines, Group 2) headed by Pierre Gressens.
1/ Basic research on IUGR and developing brain damage :
- circulating microRNAs as biomarkers of fetal growth restriction in rodents and in humans
- transcriptomic and miRs regulation in rodents
- microglial activation deregulation following fetal growth restriction : underlining mechanisms
- modulation of microglial activation and IUGR-induced neuroinflammation as neuroprotective strategy
- development / use of dendrimers for targeting siRNA against microglial activation
2/ Neuroprotective candidates pipeline and clinical translation:
- iNO and PDE5 inhibitors in neonatal stroke and HIE (+ hypothermia)
- Oxytocin, neuroinflammation modulation and neuroprotection
- PARP inhibitors
3/ Development of a novel device for for continuous functional monitoring of the neonatal brain based on ultrafast Doppler, in collaboration with ESPCI, ParisTech.
42: Soudée S, Vuillemin L, Alberti C, Mohamed D, Becquet O, Farnoux C, Biran V, Baud O. Fetal growth restriction is worse than extreme prematurity for the developing lung. Neonatology. 2014;106(4):304-10.
43: Soudée S, Schuffenecker I, Aberchih J, Josset L, Lina B, Baud O, Biran V. [Neonatal enterovirus infections reported in France in 2012]. Arch Pediatr. 2014 Sep;21(9):984-9.
44: Favrais G, Tourneux P, Lopez E, Durrmeyer X, Gascoin G, Ramful D, Zana-Taieb E, Baud O. Impact of common treatments given in the perinatal period on the developing brain. Neonatology. 2014;106(3):163-72.
45: Kadar H, Pham H, Touboul D, Brunelle A, Baud O. Impact of inhaled nitric oxide on the sulfatide profile of neonatal rat brain studied by TOF-SIMS imaging. Int J Mol Sci. 2014 Mar 25;15(4):5233-45.
46: Demené C, Pernot M, Biran V, Alison M, Fink M, Baud O, Tanter M. Ultrafast Doppler reveals the mapping of cerebral vascular resistivity in neonates. J Cereb Blood Flow Metab. 2014 Jun;34(6):1009-17.
47: Van Steenwinckel J, Schang AL, Sigaut S, Chhor V, Degos V, Hagberg H, Baud O, Fleiss B, Gressens P. Brain damage of the preterm infant: new insights into the role of inflammation. Biochem Soc Trans. 2014 Apr;42(2):557-63.
48: Biran V, Phan Duy A, Decobert F, Bednarek N, Alberti C, Baud O. Is melatonin ready to be used in preterm infants as a neuroprotectant? Dev Med Child Neurol. 2014 Aug;56(8):717-23.
49: Duong-Quy S, Hua-Huy T, Pham H, Tang X, Mercier JC, Baud O, Dinh-Xuan AT. Early inhaled nitric oxide at high dose enhances rat lung development after birth. Nitric Oxide. 2014 Apr 30;38:8-16.
50: Fleiss B, Guillot PV, Titomanlio L, Baud O, Hagberg H, Gressens P. Stem cell therapy for neonatal brain injury. Clin Perinatol. 2014 Mar;41(1):133-48.
51: Charriaut-Marlangue C, Nguyen T, Bonnin P, Duy AP, Leger PL, Csaba Z, Pansiot J, Bourgeois T, Renolleau S, Baud O. Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia. Stroke. 2014 Mar;45(3):850-6.
52: Pham H, Vottier G, Pansiot J, Duong-Quy S, Bollen B, Dalous J, Gallego J, Mercier JC, Dinh-Xuan AT, Bonnin P, Charriaut-Marlangue C, Baud O. Inhaled NO prevents hyperoxia-induced white matter damage in neonatal rats. Exp Neurol. 2014 Feb;252:114-23.
53: Zana-Taieb E, Butruille L, Franco-Montoya ML, Lopez E, Vernier F, Grandvuillemin I, Evain-Brion D, Deruelle P, Baud O, Delacourt C, Jarreau PH. Effect of two models of intrauterine growth restriction on alveolarization in rat lungs: morphometric and gene expression analysis. PLoS One. 2013 Nov 21;8(11):e78326.
54: Gaudin A, Farnoux C, Bonnard A, Alison M, Maury L, Biran V, Baud O. Necrotizing enterocolitis (NEC) and the risk of intestinal stricture: the value of C-reactive protein. PLoS One. 2013 Oct 11;8(10):e76858.
55: Lopez E, Gascoin G, Flamant C, Merhi M, Tourneux P, Baud O; French Young Neonatologist Club. Exogenous surfactant therapy in 2013: what is next? Who, when and how should we treat newborn infants in the future? BMC Pediatr. 2013 Oct 10;13:165.
56: Durrmeyer X, Hummler H, Sanchez-Luna M, Carnielli VP, Field D, Greenough A, Van Overmeire B, Jonsson B, Hallman M, Mercier JC, Marlow N, Johnson S, Baldassarre J; European Union Nitric Oxide Study Group. Two-year outcomes of a randomized controlled trial of inhaled nitric oxide in premature infants. Pediatrics. 2013 Sep;132(3):e695-703.
57: Phan Duy A, El Khabbaz F, Renolleau C, Aberchich J, Heneau A, Pham H, Baud O. [Intrauterine growth retardation and the developing brain]. Arch Pediatr. 2013 Sep;20(9):1034-8.
58: Baud O, Aujard Y. Neonatal bacterial meningitis. Handb Clin Neurol. 2013;112:1109-13.
59: Charriaut-Marlangue C, Bonnin P, Pham H, Loron G, Leger PL, Gressens P, Renolleau S, Baud O. Nitric oxide signaling in the brain: a new target for inhaled nitric oxide? Ann Neurol. 2013 Apr;73(4):442-8.
60: Guillaume S, Michelin N, Amrani E, Benier B, Durrmeyer X, Lescure S, Bony C, Danan C, Baud O, Jarreau PH, Zana-Taïeb E, Caeymaex L. Parents' expectations of staff in the early bonding process with their premature babies in the intensive care setting: a qualitative multicenter study with 60 parents. BMC Pediatr. 2013 Feb 1;13:18.
61: Leger PL, Bonnin P, Nguyen T, Renolleau S, Baud O, Charriaut-Marlangue C. Ischemic postconditioning fails to protect against neonatal cerebral stroke. PLoS One. 2012;7(12):e49695.
62: Leger PL, Bonnin P, Lacombe P, Couture-Lepetit E, Fau S, Renolleau S, Gharib A, Baud O, Charriaut-Marlangue C. Dynamic spatio-temporal imaging of early reflow in a neonatal rat stroke model. J Cereb Blood Flow Metab. 2013 Jan;33(1):137-45.