Events

Past seminars 2021

NOV 30 2021

Single-nucleus RNAseq in a model of proteinuric kidney disease

Room: B04.2222 and Zoom

Speaker: Anna FAIVRE, Prof. Sophie DE SEIGNEUX laboratory

Summary: Chronic kidney disease affects about 10% of the adult population. Proteinuria, the presence of excess proteins in the urine, plays a key role in its progression. Using single-nucleus RNA sequencing, Anna FAIVRE in collaboration with other researchers from Prof. Sophie DE SEIGNEUX’s laboratory is assessing the toxicity of proteinuria in tubular cells from the nephron, the elementary functional unit of the kidney.

 

TGFbeta activation by integrins

Room: B04.2222 and Zoom

Speaker: Michael BACHMANN, Prof. Bernhard WEHRLE-HALLER laboratory

Summary: Understanding better the activation of TGFβ by integrins might help to fight severe diseases such as cancers and fibrotic diseases. Michaël BACHMANN in collaboration with the other researchers from Bernhard WEHRLE-HALLER’s laboratory is exploring in vitro the interactions between different combinations of integrins and TGFβ with the aim to develop specific inhibitors of TGFβ.

 

NOV 23 2021

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Room: via Zoom only

Speaker: Niklas Mejhert, Dept of Medicine, Karolinska Institute, Sweden, invited by Prof. Mirko Trajkovski

Summary: -

 

NOV 16 2021

Metagenomics at subspecies resolution

Room: auditorium Boymond and Zoom

Speaker: Silas KIESER, Prof. Mirko TRAJKOVSKI laboratory

Summary: Gut microbiome symbiotically affects the functioning of our organism and might provide novel therapeutic targets for many chronic diseases. Silas KIESER in collaboration with other researchers from Prof. Mirko TRAJKOVSKI’s group is investigating the gut microbiome at the subspecies level. Their recent analyses have for example highlighted genes potentially involved in the probiotic action of a particular subspecies.

 

The effects of dietary potassium on kidney fibrosis

Room: auditorium Boymond and Zoom

Speaker: Valérie OLIVIER, Prof. Eric FERAILLE laboratory

Summary: Chronic kidney disease is a growing global health concern with few therapeutic options. This severe disease leads to renal fibrosis and loss of renal function. Valérie OLIVIER in collaboration with other researchers from Prof. Eric FERAILLE’s laboratory is exploring the opportunity to use food as medicine. Their recent experiments revealed that a high potassium intake could lead to enhanced kidney fibrosis following kidney injury by acting on the renin-angiotensin-aldosterone system.

 

NOV 9 2021

Cell-state specific ApoE lipidation in astrocytes

Room: B04.2222 and Zoom

Speaker: Karina LINDNER, Prof. Anne-Claude GAVIN laboratory

Summary: Astrocytes are involved in various neurodegenerative diseases, including Alzheimer's disease. If the importance of lipids in their dysfunction is recognized, the exact molecular mechanisms remain elusive. Karina LINDNER in collaboration with the other researchers from Prof. Anne-Claude GAVIN’s laboratory is exploring the role of a lipid transport protein, Apolipoprotein E, in the lipid metabolism of astrocytes.

 

Neutrophil extracellular trap (NET) formation in mice with Stim1/2 myeloid-specific ablation

Room: B04.2222 and Zoom

Speaker: Camille RABESAHALA DE MERITENS, Prof. Nicolas DEMAUREX laboratory

Summary: NETosis, the formation of Neutrophil Extracellular Traps NET, helps the body stop microbial infections. As NETosis is calcium dependent, it is essential to better understand the implication of the store operated calcium entry (SOCE) pathway and its associated proteins. Camille RABESAHALA DE MERITENS in collaboration with the other researchers from Prof. Nicolas DEMAUREX’s laboratory is investigating the role that STIM proteins involved in SOCE play in neutrophil functioning and NET formation.

 

NOV 2 2021

Uncovering the effect of delayed DNA replication on centrosome structure and function

Room: auditorium Renold and Zoom

Speaker: Devashish DWIVEDI, Prof. Patrick MERALDI laboratory

Summary: Cell division is a very tightly coordinated process both in space and time. DNA replication stress alters the timing of cell division and is a hallmark of many types of cancers. Devashish DWIVEDI in collaboration with other researchers from Patrick MERALDI’s laboratory conducts several cell experiments to determine the role of delayed DNA replication in regulating the centrosome structure and function during the different cell cycle phases.

 

The role of DACH1 for beta-cell function

Room: auditorium Renold and Zoom

Speaker: Cecilia JIMENEZ-SANCHEZ, Prof. Valérie SCHWITZGEBEL laboratory

Summary: Monogenic diabetes is a rare condition resulting from mutations in a single gene. Understanding the role of one of these genes, DACH1, might allow to offer more tailored treatments to patients. Cecilia JIMENEZ-SANCHEZ from Prof. Valérie SCHWITZGEBEL’s laboratory and in collaboration with other researchers, is investigating the role of DACH1 in the functioning of insulin-producing pancreatic beta cells.

 

OCT 26 2021

Pathomechanisms involved in the selective affection of skeletal muscle in X-linked Myopathy with Excessive Autophagy

Room: auditorium Boymond and via Zoom

Speaker: Ilaria COCCHIARARO, Prof. Perrine CASTETS laboratory

Summary: A better understanding of degradation processes, such as autophagy, may open new avenues for the treatment of several muscle diseases. Ilaria COCCHIARARO from Prof. Perrine CASTETS’s laboratory investigates the role of the chaperone VMA21, involved in X-linked myopathy with excessive autophagy, in order to better understand the mechanisms leading to muscle weakness and muscle atrophy in patients.

 

The role of lipid transfer proteins in the integration of metabolism

Room: auditorium Boymond and via Zoom

Speaker: Kevin TITECA, Prof. Anne-Claude GAVIN laboratory

Summary: The maintenance of a balanced lipid composition in membranes is important for many cell functions, and lipid transfer proteins play an essential role in this process. Kevin TITECA in collaboration with the other researchers from Prof. Anne-Claude GAVIN’s laboratory is investigating the mechanisms of action of lipid transfer proteins, by in silico analysis combined with results of screens for lipid transfer proteins both in cell lines and in vitro.

 

OCT 20 2021

On the roles of WNT5A in tumor progression

Room: auditorium Boymond and via Zoom

Speaker: Prof. Tommy Andersson, Experimental Pathology, Lund University

Summary: -

 

OCT 19 2021

Mutagenesis screens in Dictyostelium to find kill-deficient mutants

Room: B04.2222 and via Zoom

Speaker: Joseph ODDY, Prof. Pierre COSSON laboratory

Summary: Understanding better the mechanisms of bacterial killing by hosts might help to fight infectious diseases. Joseph ODDY in collaboration with the other researchers from Prof. Pierre COSSON’s laboratory is investigating how a unicellular model called Dictyostelium discoideum kills different bacteria. By screening killing-deficient mutants, researchers were able to highlight two new genes implicated in killing Klebsiella pneumoniae.

 

Mechanistic insights into visceral fat remodelling

Room: B04.2222 and via Zoom

Speaker: Jing XUE, Prof. Mirko TRAJKOVSKI laboratory

Summary: Adipose tissue browning is a rising therapeutic strategy in the context of obesity. Jing XUE in collaboration with other researchers from Prof. Mirko TRAJKOVSKI’s laboratory is exploring the opportunity to target visceral white fat to reduce adiposity and induce browning. Their recent experiments revealed the role of both cold exposure and gut microbiota, highlighting new pathways involved in adipose tissue browning.

 

OCT 5 2021

Feeding Inhibits the Catabolic Activity of Glutamate Dehydrogenase in Mouse Pancreatic Beta Cells as Revealed by in situ Assessment of Enzyme Activity

Room: auditorium Boymond and via Zoom

Speaker: Yan ZHOU, Prof. Pierre MAECHLER laboratory

Summary: In diabetes, the regulation of blood sugar through insulin secretion is often impaired and the role played by the glutamate dehydrogenase GDH enzyme remains poorly understood. Yan ZHOU in collaboration with other researchers from Prof. Pierre MAECHLER’s laboratory has established a new method to visualize GHD activity in situ. Using this method, they have highlighted some of the mechanisms by which dietary intake has an impact on GDH activity.

 

SEPT 28 2021

The dynamic partnered dance between PLK-1 and MEX-5: interpreting gradient formation with computational modelling

Room: auditorium Boymond and via Zoom

Speaker: Sofia BARBIERI, laboratoire de la Prof. Monica GOTTA

Summary: Molecular gradients are crucial to transmit spatial information within cells, but their formation is a complex process still poorly understood. Sofia BARBIERI in collaboration with other researchers from Monica GOTTA’s laboratory studies the formation of gradients in Caenorhabditis elegans embryos. Using innovative mathematical modelling tools, they were able to shed light on the interactions between different proteins in gradient formation.

 

The role of ERMP1 in carcinogenesis

Room: auditorium Boymond and via Zoom

Speaker: Monika GJORGJIEVA, Prof. Michelangelo FOTI laboratory

Summary: -

 

SEPT 21 2021

Novel nanobodies modulate opioid receptor function

Room: auditorium Boymond and via Zoom

Speaker: Amit KUMAR, Prof. Miriam STOEBER laboratory

Summary: Opioid receptors are a common target for pain relief. Drugs targeting these receptors can, however, cause serious side-effects and a better understanding of opioid drug action may enable the development of safer therapeutics. Amit KUMAR, in collaboration with other researchers from Miriam STOEBER’s laboratory, is using new nanobodies that modulate opioid receptor function and engineers them to block receptor signalling at defined cellular locations with the aim to reveal the precise signalling effects of opioids.

 

Circadian deregulation of glucose metabolism in diabetes

Room: auditorium Boymond and via Zoom

Speaker: Volodymyr PETRENKO, Prof. Charna DIBNER laboratory

Summary: The day and night alternation influences many physiological processes via internal clocks allowing to anticipate these alternations. When dysregulated, these internal clocks can promote metabolic diseases such as diabetes. Volodymyr PETRENKO in collaboration with other researchers from Charna DIBNER laboratory is exploring the interplay between internal clocks, physiological glucose homeostasis and development of metabolic disorders.

 

SEPT 14 2021

How genes jump: from structural insights to genome engineering applications of mobile DNA

Room: auditorium A250 and via Zoom

Speaker: Prof. Orsolya BARABAS, Department of Molecular Biology UNIGE, invited by Prof. Anne-Claude GAVIN

Summary: Prof. Orsolya BARABAS presented her recent findings on DNA transposons and their potential applications as genetic tools and therapeutic options.

 

SEPT 7 2021

Manipulation of Aurora-A position during mitosis causes cell division failure

Room: auditorium Renold and via Zoom

Speaker: Ennio SILVESTRI, Prof. Patrick MERALDI laboratory

Summary: Cell division is a tightly synchronized machinery that allows the faithful segregation of chromosomes in two daughter cells. The protein Aurora-A is a key coordinator of cell division, but its exact roles remain not fully understood. Ennio SILVESTRI in collaboration with other researchers from Patrick MERALDI’s laboratory is exploring in living cells how the localization of this protein affects cell division.

 

Investigation of translational efficiency changes in metabolically relevant tissues

Room: auditorium Renold and via Zoom

Spekaer: Pryscilla SOUSA TEIXEIRA, Prof. Roberto COPPARI laboratory

Summary: -

 

AUG 31 2021

Interleukin-18 binding protein (IL-18BP) as a liver integrity gatekeeper under nutritional stress

Room: B04.2222 and Zoom

Speaker: Emmanuel SOMM, Prof. François JORNAYVAZ laboratory

Summary: Diabetes is a pandemic disease with whole-body consequences, including fatty liver disease. If the importance of inflammation and fibrosis in the progression of fatty liver disease is recognized, some of the underlying molecular mechanisms remain elusive. Emmanuel SOMM in collaboration with the other researchers from Prof. François JORNAYAVAZ’s laboratory is exploring the role of proteins from interleukin-1 family on the balance between inflammation and fibrosis.

 

Local S-palmitoylation determines subcellular localization of Gαo

Room: B04.2222 and Zoom

Speaker: Gonzalo SOLIS, Prof. Vladimir KATANAEV laboratory

Summary: G protein-coupled receptors are membrane receptors regulating an incredible range of body functions. For signalling, they utilize signal transducers called G proteins. The mechanism of action of one G protein subunit, Gαo, remains unclear. Gonzalo SOLIS in collaboration with other researchers from Vladimir KATANAEV’s laboratory explores what drives Gαo localization within cells and how this subunit associates with membranes.

 

JUNE 29 2021

Acute Kidney Injury and glucose metabolism

Room: via Zoom

Speaker: David LEGOUIS, Pr Sophie DE SEIGNEUX laboratory

Summary: Acute kidney injury is a sudden drop in renal function that affects more than 20% of intensive care patients. As kidneys play a major role in glucose metabolism, David LEGOUIS in collaboration with other researchers from Sophie DE SEIGNEUX laboratory is investigating how gluconeogenesis, the generation of new glucose molecules, is modified in acute kidney injury and how it influences the course of the disease.

 

WNT/PCP signalling: searching for the missing ligand

Room: via Zoom

Speaker: Jana VALNOHOVA, Pr. Vladimir KATANAEV laboratory

Summary: The Wnt-planar cell polarity (PCP) signaling pathway is involved in key processes such as cell polarization.  proliferation. As deregulation of this pathway leads to serious diseases including cancer, by promoting the metastatic potential of the cancer calls, it is essential to understand what activates it. Jana VALNOHOVA in collaboration with the other researchers from Vladimir KATANAEV laboratory aims to determine which ligand can activate this pathway during development by using the fruit fly as a model.

 

JUNE 22 2021

Towards a better management of insulin deficiency

Room: via Zoom

Speaker: Gloria URSINO, Pr. Roberto COPPARI laboratory

Summary: -

 

STIM1L KO mice: Is there a skeletal muscle phenotype?

Room: via Zoom

Speaker: Stéphane KOENIG, Pr Maud FRIEDEN laboratory

Summary: Skeletal muscle regeneration is an essential process where calcium signaling plays a crucial role. Stéphane KOENIG in collaboration with the other researchers from Maud FRIEDEN laboratory has developed a new mouse line to study the role of calcium signaling in the process of muscle physiology and in particular the involvement of the STIM1L protein.

 

JUNE 15 2021

The battle between P. aeruginosa and D. discoideum

Room: via Zoom

Speaker: Imen AYADI, Pr. Pierre COSSON laboratory

Summary: Pseudomonas aeruginosa is a bacterium known for its antibiotic resistance and responsible of severe infections. Understanding by which exact mechanisms it can be killed might help to develop new therapeutic strategies. Imen AYADI in collaboration with other researchers from Pierre COSSON laboratory has been able to highlight with Dictyostelium discoideum as a model some of the mechanisms involved in both intracellular and extracellular killing.

 

UNC93B1 regulates STIM1 mobility and interaction with ORAI1

Room: via Zoom

Speaker: Jennifer WANG, Pr. Nicolas DEMAUREX laboratory

Summary: Cellular calcium entry, specifically store-operated calcium entry, is important for many cellular processes and responses, including immune cell signaling. Calcium signal is mediated by the activation of the protein STIM1 and modulated by interaction with the UNC93B1 protein chaperone. Jennifer Wen-An WANG, in collaboration with other researchers from the laboratory of Nicolas DEMAUREX, investigates the mechanism behind the UNC93B1-STIM1 interaction and explores its role in non-immunogenic cells.

 

JUNE 8 2021

Ion channels in cancer: Yes, I CAN

Room: via Zoom, registration required for non-PHYM members

Speaker: Prof. Christine Peinelt, Institute of Biochemistry and Molecular Medicine, University of Bern

Summary: -

 

JUNE 1 2021

miR-149 in Non-Alcoholic Fatty Liver Disease

Room: via Zoom

Speaker: Marta CORREIA DE SOUSA, Pr. Michelangelo FOTI laboratory

Summary: -

 

Tuning integrin beta1 specific functions in fibrosis and vascular niches

Room: via Zoom

Speaker: Adama SIDIBE, Pr. Bernhard WEHRLE-HALLER laboratory

Summary: -

 

MAY 25 2021

Molecular Mechanisms Controlling the Expression and Dynamics of Synaptic Proteins in Muscle

Room: via Zoom

Speaker: Olivia CATTANEO, Pr Perrine CASTETS laboratory

Summary: Muscles are affected in many pathological conditions, such as aging. However, the mechanisms leading to muscle decline remain often unknown. Olivia CATTANEO, from Prof. Perrine CASTETS laboratory, is investigating the role of specific factors in the maintenance of the synapse connecting motoneurons to muscles, and their contribution to muscle deterioration in pathological conditions.

 

PLD and “Bad” proteins in Dictyostelium discoideum

Room: via Zoom

Speaker: Otmane LAMRABET, Pr. Pierre COSSON laboratory

Summary: Understanding better the mechanisms of bacterial killing by hosts might help to fight infectious diseases. Otmane LAMRABET in collaboration with the other researchers from Prof. Pierre COSSON laboratory is investigating how a unicellular model called Dictyostelium discoideum kills different bacteria. Their experiments highlighted two types of proteins implicated in bacterial destruction, a phospholipase D belonging to the phospholipase superfamily and three Bad (Bacteriolytic dictyostelium) proteins belonging to the new family of bacteriolytic proteins in D. discoideum.

 

MAY 18 2021

Wnt and TGFβ Signaling in Cystic Fibrosis Airway Epithelium Differentiation

Room: via Zoom

Speaker: Tahir IDRIS, Pr. Marc CHANSON laboratory

Summary: Cystic fibrosis is a severe genetic disease affecting airway epithelium. Understanding better airway epithelium repair process might provide new therapeutic issues. Tahir IDRIS together with the other researchers from Marc CHANSON’s laboratory explores the contribution of several signaling pathways in the proliferation and differentiation of the airway epithelium.

 

Microbiota mediated fat whitening enhances anti-tumor immune response under warm exposure

Room: via Zoom

Speaker: Haiping WANG, Pr. Mirko TRAJKOVSKI laboratory

Summary: Temperature might play a role in the development of some cancers, such as melanoma and lung cancer. Understanding better how temperature influences tumor growth can provide new therapeutic applications to restrain cancer progression. Haiping WANG together with the other researchers from Mirko TRAJKOVSKI’s laboratory explores the role played by both gut microbiota and fat in the response of tumors to warm exposure.

 

MAY 11 2021

STIM1 isoforms in human skeletal muscle: what is their role during maturation?

Room: via Zoom

Speaker: Jessica BRUNETTI, Pr. Maud FRIEDEN laboratory

Summary: Calcium is a key element involved in the regulation of many cellular processes. Thestore operated calcium entry (SOCE) pathway is of particular importance for muscles. Jessica BRUNETTI together with the other researchers from Maud FRIEDEN’s laboratory is exploring the role of different isoforms of a protein called STIM1 in SOCE pathway, at the beginning of muscle formation and during their maturation.

 

Involvement of extracellular ATP signalling in the diabetogenic response of pancreatic beta-cells

Room: via Zoom

Speaker: Thierry BRUN, Pr. Pierre MAECHLER laboratory

Summary: Fructose is a widely used artificial sweetener, associated with the increase of obesity and metabolic disorders. Thierry BRUN and researchers from Pierre MAECHLER’s laboratory are exploring the effect of chronic fructose on beta-cells from the pancreas. Their experiments revealed an extracellular ATP signalling pathway involved in the response of beta-cells to fructose. They discovered also the key role of two components of this pathway, ectonucleotidases and purinergic receptors, components that could represent future therapeutic targets.

 

MAY 6 2021

Visualizing cellular lipids with shotgun mass spectrometry, 12:30

Room: via Zoom only, registration required

Speaker: Kenji MAEDA, Cell death and Metabolism unit, Danish Cancer Society Research Center (Danemark)

Summary: -

 

MAY 4 2021

Sequential action of antibacterial effectors in Dictyostelium discoideum phagosomes

Room: via Zoom

Speaker: Xènia CRESPO, Pr. Pierre COSSON laboratory

Summary: Understanding how immune cells kill bacteria is a key issue to develop new strategies for the prevention and treatment of many diseases. Xènia CRESPO in collaboration with the other researchers from Prof. Pierre COSSON laboratory is developing a new live imaging method based on a unicellular model called Dictyostelium discoideum. This so-called growth test open perspectives to build more accurate models of intracellular bacterial killing and degradation.

 

 

Role of oxidative stress in osteoarthritis

Room: via Zoom

Speaker: Félix RENAUDIN, Pr. Didier HANNOUCHE laboratory

Summary: Osteoarthritis is a very frequent inflammatory disease which affects joint cartilage. Oxidative stress might play a role in the progression of the disease, enhancing inflammation and cartilage degradation. Félix RENAUDIN in collaboration with other researchers from Didier HANNOUCHE’s laboratory is investigating the role that NADPH oxidase 4,a particular enzyme involved in oxidative stress, plays in osteoarthritis.

 

APR 27 2020

The effect of protein-rich liquid diet on metabolism: a study spanning human to mice

Room: via Zoom

Speaker: Melis COLAKOGLU, Pr. Mirko TRAJKOVSKI laboratory

Summary: Obesity is a rising health problem leading to severe complications. For severely overweight patients, bariatric surgery is often proposed. Liquid high protein diet is often applied before the surgical procedure, however, its exact metabolic effects remain unexplored. Melis COLAKOGLU from Mirko TRAJKOVSKI’s laboratory in close collaboration with scientists from HUG is investigating the effect of this diet on different organs in both mice and humans.

 

GPCR signaling selectivity at different cellular locations

Room: via Zoom

Speaker: Kevin ASSOUMOU, Pr. Miriam STOEBER laboratory

Summary: G protein-coupled receptors (GPCRs) are a large family of receptors, transducing extracellular stimuli into cellular responses. They are targeted by many approved drugs, such as opioid drugs. Kevin ASSOUMOU in collaboration with other researchers from Miriam STOEBER’s laboratory is investigating the importance of the location of GPCRs in the cell for signal transduction.

 

APR 20 2021

FKBP10 is a promising molecular target against colorectal cancer

Room: via Zoom

Speaker: Raquel FIRNKES, Pr. Roberto COPPARI laboratory

Summary: The protein FKBP10 has been recently highlighted as a promising therapeutic target against lung cancer by the laboratory of Roberto COPPARI. Raquel FIRNKES in collaboration with the other researchers from this team is now establishing the relevance of this protein in the fight against another cancer, colorectal cancer.

 

 

Towards repositioning clofazimine as targeted therapy for a broader range of Wnt-dependent cancers

Room: via Zoom

Speaker: Jiabin XU, Pr. Vladimir KATANAEV laboratory

Summary: Aberrant activation of Wnt signaling pathway leads to many cancers. In the case of a highly morbid cancer, the triple-negative breast cancer, drug repurposing may allow to discover new therapeutic options based on existing drugs. Jiabin XU in collaboration with other researchers from Vladimir KATANAEV’s laboratory explores the potential of a promising drug, clofazimine. Researchers have confirmed anti-Wnt and anti-cancer properties of clofazimine for triple negative breast cancer and demonstrated its potential effect against other Wnt-dependent cancers. They are now probing for the target(s) of clofazimine in Wnt signaling pathway.

 

APR 13 2021

AUBPs in liver metabolic diseases and hepatocellular carcinoma

Room: via Zoom

Speaker: Dobrochna DOLICKA, Pr. Michelangelo FOTI laboratory

Summary: -

 

Integrins, TGFbeta, and how they interact

Room: via Zoom

Speaker: Michael BACHMANN, Pr. Bernhard WEHRLE-HALLER laboratory

Summary: Understanding better the activation of TGFβ by integrins might help to fight severe diseases such as cancers and autoimmune diseases. Michaël BACHMANN in collaboration with the other researchers from Bernhard WEHRLE-HALLER’s laboratory is investigating how different isoforms of TGFβ are activated. With in vitro experiments, they are exploring the interactions between different combinations of integrins and TGFβ.

 

MAR 30 2021

Enzymes at work - specificity determinants of protein phosphatases

Room: via Zoom, inscription obligatoire pour les personnes externes au département

Speaker: Pr Jakob NILSSON, Center for Protein Research, University Copenhagen (Danemark)

Summary: -

 

MAR 23 2021

Role of Dictyostelium discoideum lysozymes in intracellular killing of bacteria

Room: via Zoom

Speaker: Tania JAUSLIN, Pr. Pierre COSSON laboratory

Summary: Understanding how immune cells kill bacteria is a key issue to develop new strategies for the prevention and treatment of infectious and immune-mediated diseases. Tania JAUSLIN in collaboration with the other researchers from Prof. Pierre COSSON laboratory is exploring the contribution of different bacterial killing mechanisms. These experiments revealed a high specificity in killing mechanisms with large qualitative and quantitative differences between bacteria.

 

Opioid receptor signaling at intracellular compartments

Room: via Zoom

Speaker: Lucie OBERHAUSER, Pr Miriam STOEBER laboratory

Summary: Opioids are highly efficient in relieving pain. However, they are highly addictive and prolonged exposure can lead to severe health issues and death. Understanding better the signaling pathways of G protein-coupled receptors targeted by opioids might help developing safer medications for pain management. Lucie OBERHAUSER in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory is studying the impact of receptors’ localization on their response, with a particular emphasis on signaling occurring at the Golgi system.

 

MAR 16 2021

Calcium fluxes at endoplasmic reticulum - plasma membrane contact sites

Room: via Zoom

Speaker: Christopher HENRY, Pr. Nicolas DEMAUREX laboratory

Summary: Calcium is an essential element that is involved in many cell signaling pathways. The store operated calcium entry (SOCE) pathway controls important functions ranging from gene expression to regulation of proliferation. Christopher HENRY in collaboration with other researchers from Pr. Nicolas DEMAUREX laboratory investigates in vitro the regulation of calcium fluxes, with a particular emphasis on the role of the distance between cell membrane and endoplasmic reticulum in SOCE pathway modulation.

 

Early gut colonization and adipose tissue browning

Room: via Zoom

Speaker: Vincent BERWEILER, Pr. Mirko TRAJKOVSKI laboratory

Summary: -

 

MAR 9 2021

Drug Discovery and Development Targeting Wnt Signaling in Cancer

Room: via Zoom

Speaker: Yonika LARASATI, Pr. Vladimir KATANAEV laboratory

Summary: Triple-negative breast cancer is the breast cancer with the worst prognosis. In this cancer, Wnt signaling pathway is dysregulated and finding agents targeting the upper level of this pathway may improve therapeutical approaches. Yonika LARASATI in collaboration with other researchers from Prof. Vladimir KATANAEV’s group is exploring the mechanism of action of three potential compounds targeting Wnt signaling which might be able to fight triple-negative breast cancer with lower side effects than conventional treatments.

 

Circadian regulation of metabolism in physiology and type 2 diabetes

Room: via Zoom

Speaker: Oksana FIAMMINGO, Pr Charna DIBNER laboratory

Summary: The day and night alternation controls many physiological processes. When dysregulated, these circadian clocks can promote metabolic diseases such as diabetes. Oksana FIAMINGO in collaboration with other researchers from Pr. Charna DIBNER laboratory is exploring the impact of these clocks on skeletal myotubes, which are known to be affected by diabetes.

 

MAR 2 2021

HURP an intriguing microtubule binding protein

Room: via Zoom

Speaker: Cédric CASTROGIOVANNI, Pr. Patrick MERALDI laboratory

Summary: -

 

The role of HIF1-a/FIH axis in chronic kidney disease

Room: via Zoom

Speaker: Anna FAIVRE, Pr Sophie DE SEIGNEUX laboratory

Summary: Chronic kidney disease affects about 10% of the adult population and hypoxia might play a role in its progression. Anna FAIVRE in collaboration with other researchers from Prof. Sophie DE SEIGNEUX laboratory is exploring the role of two factors called HIF and FIH in chronic kidney disease progression, with the hope to develop new therapeutic avenues.

 

 

FEB 23 2021

Cell polarity establishment: a balance between kinases and phosphatases

Room: via Zoom

Speaker: Ida CALVI, Pr Monica GOTTA laboratory

Summary: -

 

Role of phosphatidylinostiol transfer proteins (PITP) at ER-phagosome contact sites

Room: via Zoom

Speaker: Mayis KABA, Pr. Nicolas DEMAUREX laboratory

Summary: Phagocytosis is a fundamental mechanism essential for immunity and tissue functioning. During phagocytosis, membrane contact sites between phagosomes and endoplasmic reticulum take place. Mayis KABA in collaboration with other researchers from Prof. Nicolas DEMAUREX laboratory is exploring the molecular mechanisms by which phosphatidylinositol transfer proteins sustain local calcium signaling at these membrane contact sites.

 

FEB 16 2021

Biological nanostructures: molecular mechanisms and bioengineering

Room: via Zoom

Speaker: Mikhail KRYUCHKOV, Pr. Vladimir KATANAEV laboratory

Summary: Insects build microscopic structures on their surface, called nanocoatings. Understanding how there are built may provide new therapeutic avenues. Mikhail KRYUCHKOV in collaboration with other researchers from Prof. Vladimir KATANAEV laboratory has developed a process to produce nanocoatings in vitro. They are now exploring their antiadhesive and bactericidal properties to develop medical applications.

 

TIA1 and Stress Granules in hepatocellular carcinoma

Room: via Zoom

Speaker: Cyril SOBOLEWSKI, Pr. Michelangelo FOTI laboratory

Summary: -

 

FEB 9 2021

Cystic fibrosis airway epithelium susceptibility to Pseudomonas aeruginosa infection

Room: via Zoom

Speaker: Juliette SIMONIN, Pr. Marc CHANSON laboratory

Summary: Cystic fibrosis is a genetic disease leading to multiple symptoms. Associated respiratory infection by Pseudomonas aeruginosa is a major cause of mortality. Juliette SIMONIN in collaboration with the other researchers from Prof. Marc CHANSON laboratory is investigating the cellular mechanisms by which airway surface liquid protects airways against P. aeruginosa.

 

FEB 2 2021

Development of a photocaged Plk1 inhibitor

Room: via Zoom

Speaker: Victoria VON GLASENAPP, Pr Monica GOTTA laboratory

Summary: -

 

Nephrotic Syndrome: Emerging role of the paracellular chloride pathway

Room: via Zoom

Speaker: Ali SASSI, Pr Eric FERAILLE laboratory

Summary: Sodium is required to maintain normal blood pressure. Sodium reabsorption occurs in the renal collecting duct, through two different pathways: across cells through epithelial sodium channels and between cells through tight junctions. Ali SASSI in collaboration with other researchers from Pr. Eric FERAILLE laboratory showed that tight junctions have a role to play in sodium homeostasis.

 

JAN 26 2021

iPSCs and brain diseases – from modelling Alzheimer’s to treating stroke

Room: via Zoom

Speaker: Christian TACKENBERG, Institute for Regenerative Medicine, University of Zurich

Summary: -

 

JAN 19 2021

Uncovering how the delayed DNA replication in cancer cells impairs centrosome structure/function

Room: via Zoom

Speaker: Devashish DWIVEDI, Pr. Patrick MERALDI laboratory

Summary: Cell division is a very tightly coordinated process both in space and time. DNA replication stress alters the timing of cell division and is a hallmark of many types of cancers. Devashish DWIVEDI in collaboration with other researchers from Patrick MERALDI laboratory conducts microscopy experiments to determine the role of delayed DNA replication in regulating the centrosome structure and function during the different cell cycle phases.

 

JAN 12 2021

Role of Orai3 in the activation mechanisms of human muscle reserve cells

Room: via Zoom

Speaker: Axel TOLLANCE, Pr Maud FRIEDEN laboratory

Summary: Understanding how skeletal muscle is able to regenerate is a key issue to develop new strategies for the treatment of skeletal myopathies. A key step of muscle regeneration is the activation of muscle stem cells. Axel TOLLANCE in collaboration with the other researchers from Dr. Maud FRIEDEN laboratory is exploring in vitro the role of calcium in the activation of reserve muscle stem cells.

 

Ether lipids, sphingolipids, and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

Room: via Zoom

Speaker: Flore SINTUREL, Dr Charna DIBNER laboratory

Summary: Type 2 diabetes is a serious metabolic disorder diagnosed as an increase in blood glucose levels. However, type 2 diabetes is a very heterogenous disease and many factors contribute to the development of this disease. Flore SINTUREL in collaboration with other researchers from Dr. Charna DIBNER laboratory is exploring lipid patterns in different patient profiles to identify biomarker candidates for the characterization of type 2 diabetes.