Past seminars 2021

MAR 30 2021

Enzymes at work - specificity determinants of protein phosphatases

Room: via Zoom, inscription obligatoire pour les personnes externes au département

Speaker: Pr Jakob NILSSON, Center for Protein Research, University Copenhagen (Danemark)

Summary: -


MAR 23 2021

Role of Dictyostelium discoideum lysozymes in intracellular killing of bacteria

Room: via Zoom

Speaker: Tania JAUSLIN, Pr. Pierre COSSON laboratory

Summary: Understanding how immune cells kill bacteria is a key issue to develop new strategies for the prevention and treatment of infectious and immune-mediated diseases. Tania JAUSLIN in collaboration with the other researchers from Prof. Pierre COSSON laboratory is exploring the contribution of different bacterial killing mechanisms. These experiments revealed a high specificity in killing mechanisms with large qualitative and quantitative differences between bacteria.


Opioid receptor signaling at intracellular compartments

Room: via Zoom

Speaker: Lucie OBERHAUSER, Pr Miriam STOEBER laboratory

Summary: Opioids are highly efficient in relieving pain. However, they are highly addictive and prolonged exposure can lead to severe health issues and death. Understanding better the signaling pathways of G protein-coupled receptors targeted by opioids might help developing safer medications for pain management. Lucie OBERHAUSER in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory is studying the impact of receptors’ localization on their response, with a particular emphasis on signaling occurring at the Golgi system.


MAR 16 2021

Calcium fluxes at endoplasmic reticulum - plasma membrane contact sites

Room: via Zoom

Speaker: Christopher HENRY, Pr. Nicolas DEMAUREX laboratory

Summary: Calcium is an essential element that is involved in many cell signaling pathways. The store operated calcium entry (SOCE) pathway controls important functions ranging from gene expression to regulation of proliferation. Christopher HENRY in collaboration with other researchers from Pr. Nicolas DEMAUREX laboratory investigates in vitro the regulation of calcium fluxes, with a particular emphasis on the role of the distance between cell membrane and endoplasmic reticulum in SOCE pathway modulation.


Early gut colonization and adipose tissue browning

Room: via Zoom

Speaker: Vincent BERWEILER, Pr. Mirko TRAJKOVSKI laboratory

Summary: -


MAR 9 2021

Drug Discovery and Development Targeting Wnt Signaling in Cancer

Room: via Zoom

Speaker: Yonika LARASATI, Pr. Vladimir KATANAEV laboratory

Summary: Triple-negative breast cancer is the breast cancer with the worst prognosis. In this cancer, Wnt signaling pathway is dysregulated and finding agents targeting the upper level of this pathway may improve therapeutical approaches. Yonika LARASATI in collaboration with other researchers from Prof. Vladimir KATANAEV’s group is exploring the mechanism of action of three potential compounds targeting Wnt signaling which might be able to fight triple-negative breast cancer with lower side effects than conventional treatments.


Circadian regulation of metabolism in physiology and type 2 diabetes

Room: via Zoom

Speaker: Oksana FIAMMINGO, Pr Charna DIBNER laboratory

Summary: The day and night alternation controls many physiological processes. When dysregulated, these circadian clocks can promote metabolic diseases such as diabetes. Oksana FIAMINGO in collaboration with other researchers from Pr. Charna DIBNER laboratory is exploring the impact of these clocks on skeletal myotubes, which are known to be affected by diabetes.


MAR 2 2021

HURP an intriguing microtubule binding protein

Room: via Zoom

Speaker: Cédric CASTROGIOVANNI, Pr. Patrick MERALDI laboratory

Summary: -


The role of HIF1-a/FIH axis in chronic kidney disease

Room: via Zoom

Speaker: Anna FAIVRE, Pr Sophie DE SEIGNEUX laboratory

Summary: Chronic kidney disease affects about 10% of the adult population and hypoxia might play a role in its progression. Anna FAIVRE in collaboration with other researchers from Prof. Sophie DE SEIGNEUX laboratory is exploring the role of two factors called HIF and FIH in chronic kidney disease progression, with the hope to develop new therapeutic avenues.



FEB 23 2021

Cell polarity establishment: a balance between kinases and phosphatases

Room: via Zoom

Speaker: Ida CALVI, Pr Monica GOTTA laboratory

Summary: -


Role of phosphatidylinostiol transfer proteins (PITP) at ER-phagosome contact sites

Room: via Zoom

Speaker: Mayis KABA, Pr. Nicolas DEMAUREX laboratory

Summary: Phagocytosis is a fundamental mechanism essential for immunity and tissue functioning. During phagocytosis, membrane contact sites between phagosomes and endoplasmic reticulum take place. Mayis KABA in collaboration with other researchers from Prof. Nicolas DEMAUREX laboratory is exploring the molecular mechanisms by which phosphatidylinositol transfer proteins sustain local calcium signaling at these membrane contact sites.


FEB 16 2021

Biological nanostructures: molecular mechanisms and bioengineering

Room: via Zoom

Speaker: Mikhail KRYUCHKOV, Pr. Vladimir KATANAEV laboratory

Summary: Insects build microscopic structures on their surface, called nanocoatings. Understanding how there are built may provide new therapeutic avenues. Mikhail KRYUCHKOV in collaboration with other researchers from Prof. Vladimir KATANAEV laboratory has developed a process to produce nanocoatings in vitro. They are now exploring their antiadhesive and bactericidal properties to develop medical applications.


TIA1 and Stress Granules in hepatocellular carcinoma

Room: via Zoom

Speaker: Cyril SOBOLEWSKI, Pr. Michelangelo FOTI laboratory

Summary: -


FEB 9 2021

Cystic fibrosis airway epithelium susceptibility to Pseudomonas aeruginosa infection

Room: via Zoom

Speaker: Juliette SIMONIN, Pr. Marc CHANSON laboratory

Summary: Cystic fibrosis is a genetic disease leading to multiple symptoms. Associated respiratory infection by Pseudomonas aeruginosa is a major cause of mortality. Juliette SIMONIN in collaboration with the other researchers from Prof. Marc CHANSON laboratory is investigating the cellular mechanisms by which airway surface liquid protects airways against P. aeruginosa.


FEB 2 2021

Development of a photocaged Plk1 inhibitor

Room: via Zoom

Speaker: Victoria VON GLASENAPP, Pr Monica GOTTA laboratory

Summary: -


Nephrotic Syndrome: Emerging role of the paracellular chloride pathway

Room: via Zoom

Speaker: Ali SASSI, Pr Eric FERAILLE laboratory

Summary: Sodium is required to maintain normal blood pressure. Sodium reabsorption occurs in the renal collecting duct, through two different pathways: across cells through epithelial sodium channels and between cells through tight junctions. Ali SASSI in collaboration with other researchers from Pr. Eric FERAILLE laboratory showed that tight junctions have a role to play in sodium homeostasis.


JAN 26 2021

iPSCs and brain diseases – from modelling Alzheimer’s to treating stroke

Room: via Zoom

Speaker: Christian TACKENBERG, Institute for Regenerative Medicine, University of Zurich

Summary: -


JAN 19 2021

Uncovering how the delayed DNA replication in cancer cells impairs centrosome structure/function

Room: via Zoom

Speaker: Devashish DWIVEDI, Pr. Patrick MERALDI laboratory

Summary: Cell division is a very tightly coordinated process both in space and time. DNA replication stress alters the timing of cell division and is a hallmark of many types of cancers. Devashish DWIVEDI in collaboration with other researchers from Patrick MERALDI laboratory conducts microscopy experiments to determine the role of delayed DNA replication in regulating the centrosome structure and function during the different cell cycle phases.


JAN 12 2021

Role of Orai3 in the activation mechanisms of human muscle reserve cells

Room: via Zoom

Speaker: Axel TOLLANCE, Pr Maud FRIEDEN laboratory

Summary: Understanding how skeletal muscle is able to regenerate is a key issue to develop new strategies for the treatment of skeletal myopathies. A key step of muscle regeneration is the activation of muscle stem cells. Axel TOLLANCE in collaboration with the other researchers from Dr. Maud FRIEDEN laboratory is exploring in vitro the role of calcium in the activation of reserve muscle stem cells.


Ether lipids, sphingolipids, and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

Room: via Zoom

Speaker: Flore SINTUREL, Dr Charna DIBNER laboratory

Summary: Type 2 diabetes is a serious metabolic disorder diagnosed as an increase in blood glucose levels. However, type 2 diabetes is a very heterogenous disease and many factors contribute to the development of this disease. Flore SINTUREL in collaboration with other researchers from Dr. Charna DIBNER laboratory is exploring lipid patterns in different patient profiles to identify biomarker candidates for the characterization of type 2 diabetes.