Room: auditorium Adolphe Franceschetti (ex C150), building CD, CMU half-floor between 1st and 2nd floor

Speaker: Pr. Dorothee Günzel, Institute of Clinical Physiology, Charité Campus Benjamin Franklin, Germany, invited by Pr. Eric FERAILLE

Summary: -

Room: room B04.2222

Speaker: Loann LAUBRY, Pr. Maud FRIEDEN laboratory

Summary: Calcium is a key element involved in many cellular processes. Despite the importance of calcium regulation in muscle cells, many unknowns remain. Loann LAUBRY in collaboration with other researchers from Maud FRIEDEN’s laboratory is exploring the role of two different isoforms of a protein, STIM1 and STIM1L, known to regulate calcium entry. His work proposes that these proteins are also regulating calcium clearance during muscle formation.

Room: auditorium P. Boymond B02.2226

Speaker: Alexandre PROLA, Pr. Perrine CASTETS laboratory

Summary: -

Room: auditorium P. Boymond B02.2226

Speaker: Volodymyr PETRENKO, Pr. Charna DIBNER laboratory

Summary: The day and night alternation influences many physiological processes through internal clocks that anticipate these alternations. These internal clocks orchestrate the functioning of pancreatic islets where the rhythmic secretion of insulin and glucagon is essential to control blood glucose levels. Volodymyr PETRENKO from Charna DIBNER laboratory in collaboration with other researchers is exploring the circadian regulation of small non-coding RNAs, called miRNAs, in the alpha and beta cells from pancreatic islets, and the role this regulation plays in their function.

Room: auditorium J-L. Reverdin B02.2526

Speaker: Yonika LARASATI, Pr. Vladimir KATANAEV laboratory

Summary: Pediatric encephalopathies are rare, but severe diseases that still lack treatments. The alteration of signal transmission by G proteins plays a role in the progression and severity of these pathologies. Yonika LARASATI in collaboration with other researchers from Prof. Vladimir KATANAEV laboratory is testing hundreds of compounds to discoversmall molecules that can potentially restore the activity of G proteins in pediatric encephalopathies.

Room:  auditorium J-L. Reverdin B02.2526

Speaker: Mikhail KRYUCHKOV, Pr. Vladimir KATANAEV laboratory

Summary: Insects build microscopic structures on their surface, called nanocoatings. Understanding how there are built may have many applications, including new therapeutic avenues. Mikhail KRYUCHKOV in collaboration with other researchers from Prof. Vladimir KATANAEV’s laboratory has developed a process for producing nanocoatings in vitro. They are now, together with Prof Marc Jobin from the Hepia, exploring how to create nanopatterns of functional proteins using laser interference and holography.

Room: auditorium J-L. Reverdin B02.2526

Speaker: Pr. Rami AQEILAN, Immunology and Cancer Research, Hebrew University, Israel, invited by Pr. Vladimir KATANAEV

Summary: -

Room: auditorium P. Boymond B02.2226

Speaker: Zoé VALBRET, Pr. Miriam STOEBER laboratory

Summary: The involvement of G protein-coupled receptors (GPCRs) in many physiological processes calls for a better understanding of their functioning. Zoé VALBRET in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory is working on the engineering of new nanobodies, i.e. small antibody fragments, capable of modulating the activity of GPCRs with the ultimate objective to better understand GPCR signalling.

Room: auditorium P. Boymond B02.2226

Speaker: Lucie OBERHAUSER, Pr. Miriam STOEBER laboratory

Summary: G protein-coupled receptors (GPCRs) play ubiquitous roles in physiological processes, yet several aspects that regulate GPCR function remain unknown. Studying signalling at different subcellular locations, in particular, could provide essential new insights into the effects of endogenous ligands and exogenous GPCR-targeting drugs. Lucie OBERHAUSER, in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory, is investigating the impact of location on the GPCR downstream response, with a particular emphasis on signalling of GPCRs in endosomes.

Room: auditorium P. Boymond B02.2226

Speaker: Alexandra BONDAZ, Pr. Bernhard WEHRLE-HALLER laboratory

Summary: Glioblastoma is one of the most common and aggressive forms of brain cancer. Finding new therapeutic approaches is essential, as the chances of survival for patients are very low. Alexandra BONDAZ in collaboration with other researchers from the laboratory of Prof. Bernhard WEHRLE-HALLER and Prof. Denis MIGLIORINI is exploring the possibility of hindering the development of an adequate tumor microenvironment to limit the growth of the cancer.

Room: auditorium P. Boymond B02.2226

Speaker: Victoria VON GLASENAPP, Pr. Monica GOTTA laboratory

Summary: The human body produces 330billion new cells per day through cell division. This essential process is tightly regulated by, among others, the kinase PLK-1.Victoria VON GLASENAPP from Prof. Monica GOTTA’s laboratory in collaboration with the laboratory of Prof. Nicolas WINSSINGER is developing a new tool to control the activity of PLK-1 with light. Their innovative approach allows them to have a better temporal control over the activity of PLK-1 to study the cell cycle and it should lead to a better global understanding of cell division.

Room: auditorium P. Boymond B02.2226

Speaker: Mehdi BADAOUI, Pr. Marc CHANSON laboratory

Summary: Chronic lung infections by Pseudomonas aeruginosa is the leading cause of respiratory failure in people with cystic fibrosis. Mehdi BADAOUI in collaboration with other researchers from Prof. Marc CHANSON’s laboratory discovered that overexpression of the protein Vav3 promotes these infections by creating bacterial docking stations on airways’ surface. They identified the role played by the RNA-binding protein HuR in Vav3 overexpression, opening up new potential therapeutic options.

Room: auditorium P. Boymond B02.2226

Speaker: Amado CARRERAS SUREDA, Pr. Nicolas DEMAUREX laboratory

Summary: -

Room: auditorium P. Boymond B02.2226

Speaker: Giulia LUCIBELLO, Pr. Roberto COPPARI laboratory

Summary: After decades of research on diabetes, treatments of insulin deficiency remain unsatisfactory and sometimes lead to an overproduction of ketone bodies that are toxic to patients. Giulia LUCIBELLO in collaboration with other researchers from Prof. Roberto COPPARI laboratory is trying to determine how the protein S100A9 can reduce ketone body levels using different diabetic mouse models.

Room: auditorium P. Boymond B02.2226

Speaker: Alexandre THOMAS, Pr. Patrick MERALDI laboratory

Summary: During cell division, chromosomes are duplicated and equally distributed between two new cells. Their segregation relies on centrosomes which must also be duplicated to organize a spindle of microtubules that pull apart chromosomes. Alexandre THOMAS in collaboration with other researchers from Patrick MERALDI laboratory is carrying out microscopy experiments to determine the role of both the spindle poles and the centrosome age in the regulation of spindle (a)symmetry.

Room: auditorium P. Boymond B02.2226

Speaker: Pr. Henriette UHLENHAUT, Technical University of Munich and Helmholz Centre, Germany, invited by Pr. Charna DIBNER

Summary: -

Room: auditorium A. Renold B01.2426

Speaker: Devashish DWIVEDI, Pr. Patrick MERALDI laboratory

Summary: Centrioles are cellular structures that help separate the chromosomes into the daughter cells during cell division. Under mild replication stress, they desynchronize from the rest of the process, a mismatch that can lead to cancer. Devashish DWIVEDI in collaboration with other researchers from Patrick MERALDI’s laboratory conducts several cell experiments to determine the exact molecular mechanisms involved in centrosome desynchronization.

Room: auditorium A. Renold B01.2426

Speaker: Sofia BARBIERI, Pr. Monica GOTTA laboratory

Summary: Molecular gradients are crucial to transmit spatial information within cells, but their formation is a complex process still poorly understood. Sofia BARBIERI in collaboration with other researchers from Monica GOTTA’s laboratory studies the formation of protein gradients in Caenorhabditis elegans embryos. Combining innovative mathematical modelling tools with cell experiments, they are uncovering the mechanisms involved in the formation of the MEX-6 protein gradient.

Room: salle de séminaire SI/SII, 2e étage, bâtiment C

Speaker: Arthur RADOUX, laboratoire de la Pr Miriam STOEBER

Summary: Opioid receptors are important in pain regulation and are important targets for pain relief medication. On the cellular level, opioid drugs and endogenous opioid peptides show different opioid receptor activation patterns. In order to better understand the molecular mechanisms of opioid drug action, Arthur RADOUX, in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory, is investigating how opioid receptor activation depends on their subcellular location.