Mitochondria and energy metablism
We study how mitochondria integrate and generate metabolic signals controlling energy metabolism, with a special focus on the coupling of glucose recognition to insulin exocytosis. Previous work in beta-cells has demonstrated that the mitochondrion is the source of factor(s) generated by nutrient stimuli. This factor, we identified as being glutamate, participates to the stimulation of insulin secretion by amplifying calcium-activated exocytosis. The mitochondrial enzyme glutamate dehydrogenase plays a central role in this process and work using our tissue-specific Glud1 knockout shed a new light on these pathways. Current work investigates generation, intracellular transport, and mechanism of action of glutamate in beta-cells and central nervous system.