Monica Gotta



Lee BH, Schwager F, Meraldi P§, Gotta M§. 2017. p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man. The Journal of Cell Biology, 217:483-493.

§ Co-corresponding authors



Dickinson DJ, Schwager F, Pintard L, Gotta M, Goldstein B. 2017. A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization. Dev Cell. 42:416-434

Cirillo L, Gotta M§, Meraldi P§. 2017. The Elephant in the Room: The Role of Microtubules in Cancer. Adv Exp Med Biol. 1002:93-124

 § Co-corresponding authors


Book editor

Cell Division Machinery and Disease, 2017 Editors: Monica Gotta and Patrick Meraldi. Series “Advances in Experimental Medicine and Biology”, Springer.



Cirillo L, Thomas Y, Pintard L, Gotta M. 2016. BORA-dependent PLK1 regulation: A new weapon for cancer therapy? Mol Cell Oncol. E-collection


Parrilla A, Cirillo L, Thomas Y, Gotta M§, Pintard L§, Santamaria A§. 2016. Mitotic entry: The interplay between Cdk1, Plk1 and Bora. Cell cycle 15:3177-3182

 § Co-corresponding authors


Lee ZY, Prouteau M., Gotta M, Barral, Y. 2016. Compartmentalization of the endoplasmic reticulum in the early C. elegans embryos. The Journal of Cell Biology, in press


Thomas Y, Cirillo L, Panbianco C, Martino L, Tavernier N, Schwager F, Van Hove L, Joly N, Santamaria A, Pintard L§ , Gotta M. 2016. Cdk1 phosphorylates SPAT-1/Bora to promote Plk1 activation in C. elegans and human cells.Cell Rep. 15:510-8.

 § Co-corresponding authors



Tavernier N, Noatynska A, Panbianco C, Martino L, Van Hove L, Schwager F, Leger T, Gotta M, Pintard L§. 2015. Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. The Journal of Cell Biology, 208, 661-669.

§ Co-corresponding authors


Tavernier N, Panbianco C, Gotta M, Pintard L. 2015. Cdk1 plays matchmaker for the Polo-like Kinase and its activator SPAT-1/Bora Cell Cycle 14:2394-8. 



Noatynska A, Tavernier N, Gotta M, Pintard L§. 2013. Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Open Biol. 2013 Aug 7;3(8):130083.

§ Co-corresponding authors


Kress E and Gotta M. 2013. When the swiss clock goes wrong: regulation of Aurora A by UBXN-2/CDC-48. Cell Cycle. 2013 Sep 15;12(18):2921-2


Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer H, Meraldi P, Gotta. M. 2013. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. The Journal of Cell Biology, 201: 559-75.


Spiga F, Prouteau M, Gotta M. 2013. The TAO kinase KIN­18 regulates contractility and establishment of polarity in the C. elegans embryo. Dev Biol, 373: 26-38.



Noatynska A, Gotta M. and Meraldi P§. 2012. Mitotic spindle (DIS)orientation and DISease: cause or consequence? J Cell Biol, 199:1025-35.

§ Co-corresponding authors


Noatynska A, and Gotta M. 2012. Cell polarity and asymmetric cell division-the C. elegans early embryo. Essays Biochem, 53:1-14



Panbianco C and Gotta M. 2011. Coordinating cell polarity with cell division in space and time. Trends in Cell Biol. 21:672-80.


Kress E and Gotta M. 2011. Aurora A in cell division: kinase activity not required. Nat Cell Biol. 13:638-39.



Noatynska A, Panbianco C, Gotta M. 2010. SPAT-1/Bora acts with Polo like kinase PLK-1 to regulate PAR polarity and cell cycle progression. Development, 137(19):3315-25.


Gotta M. A cell biologist connects her research to bacterial brain invasion. Nature. 2010 Jan 14;463(7278):139. Nature Journal Club


Zanin E, Pacquelet A, Scheckel C, Ciosk R, Gotta M. 2010. LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline. Journal of Cell Science, 123:2717-24



Spilker, A.C., Rabilotta, A., Zbinden, C., Labbé, JC, Gotta, M. 2009. MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo. Genetics, 183(3):965-77



 Panbianco C, Weinkove D, Zanin E, Jones DR, Divecha N, Gotta M, and Ahringer J. 2008. A casein kinase 1 and PAR proteins regulate asymmetry of a PIP2 synthesis enzyme for asymmetric spindle positioning. Dev. Cell, 2:198-208.


Pacquelet A, Zanin E, Ashiono C, Gotta M. 2008. PAR-6 levels are regulated by NOS-3 in a FEM-1/2/3 and CUL-2 dependent manner in C. elegans. Developmental Biology, 319:267-27.



Couwenbergs C, Labbé JC, Goulding M, Marty T, Bowerman B, Gotta M. 2007. Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. J Cell Biol., 179:15-22.


Ramadan K§,  Bruderer R§, Spiga F,  Popp O, Baur T, Gotta M, Meyer HH. 2007. Cdc48/p97 promotes reformation of the nucleus by extracting Aurora B kinase from chromatin. Nature, 450:1258-62.



Labbe JC, Pacquelet A, Marty T, Gotta M. 2006. A genome-wide screen for suppressors of par-2 uncovers potential regulators of PAR-protein dependent cell polarity in C. elegans. Genetics, 174:285-95.


Parusel C, Kritikou EA, Hengartner MO, Krek W, Gotta M. 2006. URI-1 is required for DNA stability in C. elegans. Development, 133:621-29.



Bellaiche Y and Gotta M. 2005. Heterorimeric G proteins and regulation of size asymmetry during cell division. Curr. Op. Cell Biol.17: 658-663


Gotta M. 2005. At the heart of cell polarity and the cytoskeleton. Dev. Cell., 8: 629-633



Couwenbergs C, Spilker AC, Gotta M. 2004. Control of embryonic spindle positioning and Ga activity by C. elegans RIC-8. Curr. Biol., 14:1871-1876.



Gotta M, Dong Y, Peterson YK, Lanier SM, Ahringer J. 2003. Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo. Curr. Biol., 13: 1029-1037.


Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, LeBot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P Ahringer  J. 2003. Systematic functional analysis of the C. elegans genome using RNAi. Nature, 421:231-237.



Gotta M and Ahringer J. 2001.  Axis determination and polarity in C. elegans. Curr. Op. Gen. & Dev., 11:367-373.


Gotta M, Abraham M C and Ahringer J. 2001. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr. Biol., 11:482-488.


Gotta M. and Ahringer J. 2001. Distinct roles for Ga and Gbg in regulating spindle position and orientation in early C. elegans embryos. Nature Cell Biol., 3:297-300



Gotta M, Laroche T, Gasser SM. 1999. Analysis of Nuclear organization in Saccharomyces cerevisiae. Methods Enzymol, 304:663-672



Gotta M, Palladino F and Gasser SM. 1998. Functional characterization of the N terminus of Sir3p. Mol.Cell.Biol., 18:6110-6120.


Laroche T, Martin SG, Gotta M, Gorham HC, Pryde FE, Louis EJ and Gasser SM. 1998. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr.Biol. 8:653-656.


Cockell M, Gotta M, Palladino F, Martin SG, Gasser SM. 1998. Targeting Sir proteins to sites of action: a general mechanism for regulating repression. Cold Spring Harb Symp Quant Biol, 63:401-12


Gasser SM, Gotta M, Renauld H, Laroche T, Cockell M. 1998. Nuclear organization and silencing: trafficking of Sir proteins. Novartis Found Symp, 214: 114-126



Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Zhang J, Gasser SM, Guarente L. 1997. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell, 89: 381-391.


Gotta M, Strahl-Bolsinger S, Renauld H, Laroche T, Kennedy BK, Grunstein M, Gasser SM. 1997. Localization of Sir2p: the nucleolus as a compartment for Silent Information Regulators. EMBO J. 16: 3242-3255.


Gotta M. and Cockell M. 1997. Telomeres, not the end of the story. BioEssays, 19: 367-370.



Gotta M, and Gasser SM. 1996. Nuclear organization and transcriptional silencing in yeast. Experientia. 52: 1136-1147.


Gotta M, Laroche T, Formenton A, Maillet L, Scherthan H, and Gasser SM. 1996. The clustering of telomeres and colocalization with Rap1, Sir3 and Sir4 proteins in wild-type Saccharomyces cerevisiae. J.Cell Biol. 134: 1349-1363.


Maillet L, Boscheron C, Gotta M, Marcand S, Gilson E, and Gasser S. 1996. Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression. Genes Dev. 10: 1796-1811.