A review on calcium in skeletal muscle

Calcium is essential to the functioning of all cells and plays a particular role in skeletal muscle. One of the key mechanisms of calcium regulation, the store-operated calcium entry SOCE, has been extensively studied. However, knowledge about its functioning in skeletal muscle remains sparse.

In their recent review published in Cells, researchers from the group of Prof. Maud Frieden, together with the group of Dr. Xaver Koenig in Vienna, discuss what differentiates skeletal muscle SOCE from its counterpart found in non-excitable cells. They highlight the complexity of SOCE activation and its regulation in skeletal muscle, with the aim to reach a better picture of this mesmerizing phenomenon.

Microscopy image of skeletal muscle © UNIGE

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