Evénements

Séminaires passés 2021

20 OCT 2021

On the roles of WNT5A in tumor progression

Room: auditoire Boymond et via Zoom

Speaker: Prof. Tommy Andersson, Experimental Pathology, Lund University

Summary: -

 

19 OCT 2021

Mutagenesis screens in Dictyostelium to find kill-deficient mutants

Lieu: salle B04.2222 et via Zoom

Intervenant: Joseph ODDY, laboratoire du Prof. Pierre COSSON

Résumé: -

 

Mechanistic insights into visceral fat remodelling

Lieu: salle B04.2222 et via Zoom

Intervenant: Jing XUE, laboratoire du Prof. Mirko TRAJKOVSKI

Résumé: -

 

5 OCT 2021

Feeding Inhibits the Catabolic Activity of Glutamate Dehydrogenase in Mouse Pancreatic Beta Cells as Revealed by in situ Assessment of Enzyme Activity

Lieu: auditoire Boymond et via Zoom

Intervenant: Yan ZHOU, laboratoire du Prof. Pierre MAECHLER

Résumé: In diabetes, the regulation of blood sugar through insulin secretion is often impaired and the role played by the glutamate dehydrogenase GDH enzyme remains poorly understood. Yan ZHOU in collaboration with other researchers from Prof. Pierre MAECHLER’s laboratory has established a new method to visualize GHD activity in situ. Using this method, they have highlighted some of the mechanisms by which dietary intake has an impact on GDH activity.

 

28 SEPT 2021

The dynamic partnered dance between PLK-1 and MEX-5: interpreting gradient formation with computational modelling

Lieu: auditoire Boymond et via Zoom

Intervenant: Sofia BARBIERI, laboratoire de la Prof. Monica GOTTA

Résumé: Molecular gradients are crucial to transmit spatial information within cells, but their formation is a complex process still poorly understood. Sofia BARBIERI in collaboration with other researchers from Monica GOTTA’s laboratory studies the formation of gradients in Caenorhabditis elegans embryos. Using innovative mathematical modelling tools, they were able to shed light on the interactions between different proteins in gradient formation.

 

The role of ERMP1 in carcinogenesis

Lieu: auditoire Boymond et via Zoom

Intervenant: Monika GJORGJIEVA, laboratoire du Prof. Michelangelo FOTI

Résumé: -

 

21 SEPT 2021

Novel nanobodies modulate opioid receptor function

Lieu: auditoire Boymond et via Zoom

Intervenant: Amit KUMAR, laboratoire de la Prof. Miriam STOEBER

Résumé: Opioid receptors are a common target for pain relief. Drugs targeting these receptors can, however, cause serious side-effects and a better understanding of opioid drug action may enable the development of safer therapeutics. Amit KUMAR, in collaboration with other researchers from Miriam STOEBER’s laboratory, is using new nanobodies that modulate opioid receptor function and engineers them to block receptor signalling at defined cellular locations with the aim to reveal the precise signalling effects of opioids.

 

Circadian deregulation of glucose metabolism in diabetes

Lieu: auditoire Boymond et via Zoom

Intervenant: Volodymyr PETRENKO, laboratoire de la Prof. Charna DIBNER

Résumé: The day and night alternation influences many physiological processes via internal clocks allowing to anticipate these alternations. When dysregulated, these internal clocks can promote metabolic diseases such as diabetes. Volodymyr PETRENKO in collaboration with other researchers from Charna DIBNER laboratory is exploring the interplay between internal clocks, physiological glucose homeostasis and development of metabolic disorders.

 

14 SEPT 2021

How genes jump: from structural insights to genome engineering applications of mobile DNA

Lieu: auditoire A250 et via Zoom

Intervenant: Prof. Orsolya BARABAS, Département de Biologie moléculaire UNIGE, invitée par la Prof. Anne-Claude GAVIN

Résumé: Prof. Orsolya BARABAS presented her recent findings on DNA transposons and their potential applications as genetic tools and therapeutic options.

 

7 SEPT 2021

Manipulation of Aurora-A position during mitosis causes cell division failure

Lieu: auditoire Renold et via Zoom

Intervenant: Ennio SILVESTRI, laboratoire du Prof. Patrick MERALDI

Résumé: Cell division is a tightly synchronized machinery that allows the faithful segregation of chromosomes in two daughter cells. The protein Aurora-A is a key coordinator of cell division, but its exact roles remain not fully understood. Ennio SILVESTRI in collaboration with other researchers from Patrick MERALDI’s laboratory is exploring in living cells how the localization of this protein affects cell division.

 

Investigation of translational efficiency changes in metabolically relevant tissues

Lieu: auditoire Renold et via Zoom

Intervenant: Pryscilla SOUSA TEIXEIRA, laboratoire du Prof. Roberto COPPARI

Résumé: -

 

31 AOÛT 2021

Interleukin-18 binding protein (IL-18BP) as a liver integrity gatekeeper under nutritional stress

Lieu: B04.2222 et Zoom

Intervenant: Emmanuel SOMM, laboratoire du Prof. François JORNAYVAZ

Résumé: Diabetes is a pandemic disease with whole-body consequences, including fatty liver disease. If the importance of inflammation and fibrosis in the progression of fatty liver disease is recognized, some of the underlying molecular mechanisms remain elusive. Emmanuel SOMM in collaboration with the other researchers from Prof. François JORNAYAVAZ’s laboratory is exploring the role of proteins from interleukin-1 family on the balance between inflammation and fibrosis.

 

Local S-palmitoylation determines subcellular localization of Gαo

Lieu: B04.2222 et Zoom

Intervenant: Gonzalo SOLIS, laboratoire du Prof. Vladimir KATANAEV

Résumé: G protein-coupled receptors are membrane receptors regulating an incredible range of body functions. For signalling, they utilize signal transducers called G proteins. The mechanism of action of one G protein subunit, Gαo, remains unclear. Gonzalo SOLIS in collaboration with other researchers from Vladimir KATANAEV’s laboratory explores what drives Gαo localization within cells and how this subunit associates with membranes.

 

JUIN 29 2021

Acute Kidney Injury and glucose metabolism

Lieu: via Zoom

Intervenant: David LEGOUIS, laboratoire de la Pre. Sophie DE SEIGNEUX

Résumé: Acute kidney injury is a sudden drop in renal function that affects more than 20% of intensive care patients. As kidneys play a major role in glucose metabolism, David LEGOUIS in collaboration with other researchers from Sophie DE SEIGNEUX laboratory is investigating how gluconeogenesis, the generation of new glucose molecules, is modified in acute kidney injury and how it influences the course of the disease.

 

WNT/PCP signalling: searching for the missing ligand

Lieu: via Zoom

Intervenant: Jana VALNOHOVA, laboratoire du Pr. Vladimir KATANAEV

Résumé: The Wnt-planar cell polarity (PCP) signaling pathway is involved in key processes such as cell polarization.  proliferation. As deregulation of this pathway leads to serious diseases including cancer, by promoting the metastatic potential of the cancer calls, it is essential to understand what activates it. Jana VALNOHOVA in collaboration with the other researchers from Vladimir KATANAEV laboratory aims to determine which ligand can activate this pathway during development by using the fruit fly as a model.

 

JUIN 22 2021

Towards a better management of insulin deficiency

Lieu: via Zoom

Intervenant: Gloria URSINO, laboratoire du Pr. Roberto COPPARI

Résumé: -

 

STIM1L KO mice: Is there a skeletal muscle phenotype?

Lieu: via Zoom

Intervenant: Stéphane KOENIG, laboratoire de la Pre. Maud FRIEDEN

Résumé: Skeletal muscle regeneration is an essential process where calcium signaling plays a crucial role. Stéphane KOENIG in collaboration with the other researchers from Maud FRIEDEN laboratory has developed a new mouse line to study the role of calcium signaling in the process of muscle physiology and in particular the involvement of the STIM1L protein.

 

JUIN 15 2021

The battle between P. aeruginosa and D. discoideum

Lieu: via Zoom

Intervenant: Imen AYADI, laboratoire du Pr. Pierre COSSON

Résumé: Pseudomonas aeruginosa is a bacterium known for its antibiotic resistance and responsible of severe infections. Understanding by which exact mechanisms it can be killed might help to develop new therapeutic strategies. Imen AYADI in collaboration with other researchers from Pierre COSSON laboratory has been able to highlight with Dictyostelium discoideum as a model some of the mechanisms involved in both intracellular and extracellular killing.

 

UNC93B1 regulates STIM1 mobility and interaction with ORAI1

Lieu: via Zoom

Intervenant: Jennifer WANG, laboratoire du Pr. Nicolas DEMAUREX

Résumé: Cellular calcium entry, specifically store-operated calcium entry, is important for many cellular processes and responses, including immune cell signaling. Calcium signal is mediated by the activation of the protein STIM1 and modulated by interaction with the UNC93B1 protein chaperone. Jennifer Wen-An WANG, in collaboration with other researchers from the laboratory of Nicolas DEMAUREX, investigates the mechanism behind the UNC93B1-STIM1 interaction and explores its role in non-immunogenic cells.

 

JUIN 8 2021

Ion channels in cancer: Yes, I CAN

Lieu: via Zoom, sur inscription pour les personnes non-PHYM

Intervenant: Prof. Christine Peinelt, Institut de Biochimie et de Médecine moléculaire, Université de Berne

Résumé: -

 

JUIN 1 2021

miR-149 in Non-Alcoholic Fatty Liver Disease

Lieu: via Zoom

Intervenant: Marta CORREIA DE SOUSA, laboratoire du Pr. Michelangelo FOTI

Résumé: -

 

Tuning integrin beta1 specific functions in fibrosis and vascular niches

Lieu: via Zoom

Intervenant: Adama SIDIBE, laboratoire du Pr. Bernhard WEHRLE-HALLER

Résumé: -

 

MAI 25 2021

Molecular Mechanisms Controlling the Expression and Dynamics of Synaptic Proteins in Muscle

Lieu: via Zoom

Intervenant: Olivia CATTANEO, laboratoire de la Pre. Perrine CASTETS

Résumé: Muscles are affected in many pathological conditions, such as aging. However, the mechanisms leading to muscle decline remain often unknown. Olivia CATTANEO, from Prof. Perrine CASTETS laboratory, is investigating the role of specific factors in the maintenance of the synapse connecting motoneurons to muscles, and their contribution to muscle deterioration in pathological conditions.

 

PLD and “Bad” proteins in Dictyostelium discoideum

Lieu: via Zoom

Intervenant: Otmane LAMRABET, laboratoire du Pr. Pierre COSSON

Résumé: Understanding better the mechanisms of bacterial killing by hosts might help to fight infectious diseases. Otmane LAMRABET in collaboration with the other researchers from Prof. Pierre COSSON laboratory is investigating how a unicellular model called Dictyostelium discoideum kills different bacteria. Their experiments highlighted two types of proteins implicated in bacterial destruction, a phospholipase D belonging to the phospholipase superfamily and three Bad (Bacteriolytic dictyostelium) proteins belonging to the new family of bacteriolytic proteins in D. discoideum.

 

MAI 18 2021

Wnt and TGFβ Signaling in Cystic Fibrosis Airway Epithelium Differentiation

Lieu: via Zoom

Intervenant: Tahir IDRIS, laboratoire du Pr. Marc CHANSON

Résumé: Cystic fibrosis is a severe genetic disease affecting airway epithelium. Understanding better airway epithelium repair process might provide new therapeutic issues. Tahir IDRIS together with the other researchers from Marc CHANSON’s laboratory explores the contribution of several signaling pathways in the proliferation and differentiation of the airway epithelium.

 

Microbiota mediated fat whitening enhances anti-tumor immune response under warm exposure

Lieu: via Zoom

Intervenant: Haiping WANG, laboratoire du Pr. Mirko TRAJKOVSKI

Résumé: Temperature might play a role in the development of some cancers, such as melanoma and lung cancer. Understanding better how temperature influences tumor growth can provide new therapeutic applications to restrain cancer progression. Haiping WANG together with the other researchers from Mirko TRAJKOVSKI’s laboratory explores the role played by both gut microbiota and fat in the response of tumors to warm exposure.

 

MAI 11 2021

STIM1 isoforms in human skeletal muscle: what is their role during maturation?

Lieu: via Zoom

Intervenant: Jessica BRUNETTI, laboratoire de la Pre. Maud FRIEDEN

Résumé: Calcium is a key element involved in the regulation of many cellular processes. Thestore operated calcium entry (SOCE) pathway is of particular importance for muscles. Jessica BRUNETTI together with the other researchers from Maud FRIEDEN’s laboratory is exploring the role of different isoforms of a protein called STIM1 in SOCE pathway, at the beginning of muscle formation and during their maturation.

 

Involvement of extracellular ATP signalling in the diabetogenic response of pancreatic beta-cells

Lieu: via Zoom

Intervenant: Thierry BRUN, laboratoire du Pr. Pierre MAECHLER

Résumé: Fructose is a widely used artificial sweetener, associated with the increase of obesity and metabolic disorders. Thierry BRUN and researchers from Pierre MAECHLER’s laboratory are exploring the effect of chronic fructose on beta-cells from the pancreas. Their experiments revealed an extracellular ATP signalling pathway involved in the response of beta-cells to fructose. They discovered also the key role of two components of this pathway, ectonucleotidases and purinergic receptors, components that could represent future therapeutic targets.

 

MAI 6 2021

Visualizing cellular lipids with shotgun mass spectrometry, 12:30

Lieu: par Zoom uniquement, sur inscription

Intervenant: Kenji MAEDA, Cell death and Metabolism unit, Danish Cancer Society Research Center (Danemark)

Résumé: -

 

MAI 4 2021

Sequential action of antibacterial effectors in Dictyostelium discoideum phagosomes

Lieu: via Zoom

Intervenant: Xènia CRESPO, laboratoire du Pr. Pierre COSSON

Résumé: Understanding how immune cells kill bacteria is a key issue to develop new strategies for the prevention and treatment of many diseases. Xènia CRESPO in collaboration with the other researchers from Prof. Pierre COSSON laboratory is developing a new live imaging method based on a unicellular model called Dictyostelium discoideum. This so-called growth test open perspectives to build more accurate models of intracellular bacterial killing and degradation.

 

 

Role of oxidative stress in osteoarthritis

Lieu: via Zoom

Intervenant: Félix RENAUDIN, laboratoire du Pr. Didier HANNOUCHE

Résumé: Osteoarthritis is a very frequent inflammatory disease which affects joint cartilage. Oxidative stress might play a role in the progression of the disease, enhancing inflammation and cartilage degradation. Félix RENAUDIN in collaboration with other researchers from Didier HANNOUCHE’s laboratory is investigating the role that NADPH oxidase 4,a particular enzyme involved in oxidative stress, plays in osteoarthritis.

 

AVR 27 2020

The effect of protein-rich liquid diet on metabolism: a study spanning human to mice

Lieu: via Zoom

Intervenant: Melis COLAKOGLU, laboratoire du Pr. Mirko TRAJKOVSKI

Résumé: Obesity is a rising health problem leading to severe complications. For severely overweight patients, bariatric surgery is often proposed. Liquid high protein diet is often applied before the surgical procedure, however, its exact metabolic effects remain unexplored. Melis COLAKOGLU from Mirko TRAJKOVSKI’s laboratory in close collaboration with scientists from HUG is investigating the effect of this diet on different organs in both mice and humans.

 

GPCR signaling selectivity at different cellular locations

Lieu: via Zoom

Intervenant: Kevin ASSOUMOU, laboratoire de la Pre. Miriam STOEBER

Résumé: G protein-coupled receptors (GPCRs) are a large family of receptors, transducing extracellular stimuli into cellular responses. They are targeted by many approved drugs, such as opioid drugs. Kevin ASSOUMOU in collaboration with other researchers from Miriam STOEBER’s laboratory is investigating the importance of the location of GPCRs in the cell for signal transduction.

 

AVR 20 2021

FKBP10 is a promising molecular target against colorectal cancer

Lieu: via Zoom

Intervenant: Raquel FIRNKES, laboratoire du Pr. Roberto COPPARI

Résumé: The protein FKBP10 has been recently highlighted as a promising therapeutic target against lung cancer by the laboratory of Roberto COPPARI. Raquel FIRNKES in collaboration with the other researchers from this team is now establishing the relevance of this protein in the fight against another cancer, colorectal cancer.

 

 

Towards repositioning clofazimine as targeted therapy for a broader range of Wnt-dependent cancers

Lieu: via Zoom

Intervenant: Jiabin XU, laboratoire du Pr. Vladimir KATANAEV

Résumé: Aberrant activation of Wnt signaling pathway leads to many cancers. In the case of a highly morbid cancer, the triple-negative breast cancer, drug repurposing may allow to discover new therapeutic options based on existing drugs. Jiabin XU in collaboration with other researchers from Vladimir KATANAEV’s laboratory explores the potential of a promising drug, clofazimine. Researchers have confirmed anti-Wnt and anti-cancer properties of clofazimine for triple negative breast cancer and demonstrated its potential effect against other Wnt-dependent cancers. They are now probing for the target(s) of clofazimine in Wnt signaling pathway.

 

AVR 13 2021

AUBPs in liver metabolic diseases and hepatocellular carcinoma

Lieu: via Zoom

Intervenant: Dobrochna DOLICKA, laboratoire du Pr. Michelangelo FOTI

Résumé: -

 

Integrins, TGFbeta, and how they interact

Lieu: via Zoom

Intervenant: Michael BACHMANN, laboratoire du Pr. Bernhard WEHRLE-HALLER

Résumé: Understanding better the activation of TGFβ by integrins might help to fight severe diseases such as cancers and autoimmune diseases. Michaël BACHMANN in collaboration with the other researchers from Bernhard WEHRLE-HALLER’s laboratory is investigating how different isoforms of TGFβ are activated. With in vitro experiments, they are exploring the interactions between different combinations of integrins and TGFβ.

 

MAR 30 2021

Enzymes at work - specificity determinants of protein phosphatases

Lieu: via Zoom, inscription pour les personnes externes au département

Intervenant: Pr Jakob NILSSON, Center for Protein Research, University Copenhagen (Danemark)

Résumé: -

 

MAR 23 2021

Role of Dictyostelium discoideum lysozymes in intracellular killing of bacteria

Lieu: via Zoom

Intervenant: Tania JAUSLIN, laboratoire du Pr. Pierre COSSON

Résumé: Understanding how immune cells kill bacteria is a key issue to develop new strategies for the prevention and treatment of infectious and immune-mediated diseases. Tania JAUSLIN in collaboration with the other researchers from Prof. Pierre COSSON laboratory is exploring the contribution of different bacterial killing mechanisms. These experiments revealed a high specificity in killing mechanisms with large qualitative and quantitative differences between bacteria.

 

Opioid receptor signaling at intracellular compartments

Lieu: via Zoom

Intervenant: Lucie OBERHAUSER, laboratoire de la Pre. Miriam STOEBER

Résumé: Opioids are highly efficient in relieving pain. However, they are highly addictive and prolonged exposure can lead to severe health issues and death. Understanding better the signaling pathways of G protein-coupled receptors targeted by opioids might help developing safer medications for pain management. Lucie OBERHAUSER in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory is studying the impact of receptors’ localization on their response, with a particular emphasis on signaling occurring at the Golgi system.

 

MAR 16 2021

Calcium fluxes at endoplasmic reticulum - plasma membrane contact sites

Lieu: via Zoom

Intervenant: Christopher HENRY, laboratoire du Pr. Nicolas DEMAUREX

Résumé: Calcium is an essential element that is involved in many cell signaling pathways. The store operated calcium entry (SOCE) pathway controls important functions ranging from gene expression to regulation of proliferation. Christopher HENRY in collaboration with other researchers from Pr. Nicolas DEMAUREX laboratory investigates in vitro the regulation of calcium fluxes, with a particular emphasis on the role of the distance between cell membrane and endoplasmic reticulum in SOCE pathway modulation.

 

Early gut colonization and adipose tissue browning

Lieu: via Zoom

Intervenant: Vincent BERWEILER, laboratoire du Pr. Mirko TRAJKOVSKI

Résumé: -

 

MAR 9 2021

Drug Discovery and Development Targeting Wnt Signaling in Cancer

Lieu: via Zoom

Intervenant: Yonika LARASATI, laboratoire du Pr. Vladimir KATANAEV

Résumé: Triple-negative breast cancer is the breast cancer with the worst prognosis. In this cancer, Wnt signaling pathway is dysregulated and finding agents targeting the upper level of this pathway may improve therapeutical approaches. Yonika LARASATI in collaboration with other researchers from Prof. Vladimir KATANAEV’s group is exploring the mechanism of action of three potential compounds targeting Wnt signaling which might be able to fight triple-negative breast cancer with lower side effects than conventional treatments.

 

Circadian regulation of metabolism in physiology and type 2 diabetes

Lieu: via Zoom

Intervenant: Oksana FIAMMINGO, laboratoire de la Pre. Charna DIBNER

Résumé: The day and night alternation controls many physiological processes. When dysregulated, these circadian clocks can promote metabolic diseases such as diabetes. Oksana FIAMINGO in collaboration with other researchers from Pr. Charna DIBNER laboratory is exploring the impact of these clocks on skeletal myotubes, which are known to be affected by diabetes.

 

MAR 2 2021

HURP an intriguing microtubule binding protein

Lieu: via Zoom

Intervenant: Cédric CASTROGIOVANNI, laboratoire du Pr. Patrick MERALDI

Résumé: -

 

The role of HIF1-a/FIH axis in chronic kidney disease

Lieu: via Zoom

Intervenant: Anna FAIVRE, laboratoire de la Pre. Sophie DE SEIGNEUX

Résumé: Chronic kidney disease affects about 10% of the adult population and hypoxia might play a role in its progression. Anna FAIVRE in collaboration with other researchers from Prof. Sophie DE SEIGNEUX laboratory is exploring the role of two factors called HIF and FIH in chronic kidney disease progression, with the hope to develop new therapeutic avenues.

 

 

FÉV 23 2021

Cell polarity establishment: a balance between kinases and phosphatases

Lieu: via Zoom

Intervenant: Ida CALVI, laboratoire de la Pre. Monica GOTTA

Résumé: -

 

Role of phosphatidylinostiol transfer proteins (PITP) at ER-phagosome contact sites

Lieu: via Zoom

Intervenant: Mayis KABA, laboratoire du Pr. Nicolas DEMAUREX

Résumé: Phagocytosis is a fundamental mechanism essential for immunity and tissue functioning. During phagocytosis, membrane contact sites between phagosomes and endoplasmic reticulum take place. Mayis KABA in collaboration with other researchers from Prof. Nicolas DEMAUREX laboratory is exploring the molecular mechanisms by which phosphatidylinositol transfer proteins sustain local calcium signaling at these membrane contact sites.

 

FÉV 16 2021

Biological nanostructures: molecular mechanisms and bioengineering

Lieu: via Zoom

Intervenant: Mikhail KRYUCHKOV, laboratoire du Pr. Vladimir KATANAEV

Résumé: Insects build microscopic structures on their surface, called nanocoatings. Understanding how there are built may provide new therapeutic avenues. Mikhail KRYUCHKOV in collaboration with other researchers from Prof. Vladimir KATANAEV laboratory has developed a process to produce nanocoatings in vitro. They are now exploring their antiadhesive and bactericidal properties to develop medical applications.

 

TIA1 and Stress Granules in hepatocellular carcinoma

Lieu: via Zoom

Intervenant: Cyril SOBOLEWSKI, laboratoire du Pr. Michelangelo FOTI

Résumé: -

 

FÉV 9 2021

Cystic fibrosis airway epithelium susceptibility to Pseudomonas aeruginosa infection

Lieu: via Zoom

Intervenant: Juliette SIMONIN, laboratoire du Pr. Marc CHANSON

Résumé: Cystic fibrosis is a genetic disease leading to multiple symptoms. Associated respiratory infection by Pseudomonas aeruginosa is a major cause of mortality. Juliette SIMONIN in collaboration with the other researchers from Prof. Marc CHANSON laboratory is investigating the cellular mechanisms by which airway surface liquid protects airways against P. aeruginosa.

 

S-acylation regulates ORAI1 distribution in membrane lipids to promote efficient Ca2+ signalling by T cell receptors at the immune synapse

Lieu:  via Zoom

Intervenant: Amado CARRERAS SUREDA, laboratoire du Pr. Nicolas DEMAUREX

Résumé: -

 

FÉV 2 2021

Development of a photocaged Plk1 inhibitor

Lieu: via Zoom

Intervenant: Victoria VON GLASENAPP, laboratoire de la Pre. Monica GOTTA

Résumé: -

 

Nephrotic Syndrome: Emerging role of the paracellular chloride pathway

Lieu: via Zoom

Intervenant: Ali SASSI, laboratoire du Pr. Eric FERAILLE

Résumé: Sodium is required to maintain normal blood pressure. Sodium reabsorption occurs in the renal collecting duct, through two different pathways: across cells through epithelial sodium channels and between cells through tight junctions. Ali SASSI in collaboration with other researchers from Pr. Eric FERAILLE laboratory showed that tight junctions have a role to play in sodium homeostasis.

 

JAN 26 2021

iPSCs and brain diseases – from modelling Alzheimer’s to treating stroke

Lieu: via Zoom

Intervenant: Dr Christian TACKENBERG, Institute for Regenerative Medicine, University of Zurich

Résumé: -

 

JAN 19 2021

Uncovering how the delayed DNA replication in cancer cells impairs centrosome structure/function

Lieu: via Zoom

Intervenant: Devashish DWIVEDI, laboratoire du Pr. Patrick MERALDI

Résumé: Cell division is a very tightly coordinated process both in space and time. DNA replication stress alters the timing of cell division and is a hallmark of many types of cancers. Devashish DWIVEDI in collaboration with other researchers from Patrick MERALDI laboratory conducts microscopy experiments to determine the role of delayed DNA replication in regulating the centrosome structure and function during the different cell cycle phases.

 

JAN 12 2021

Role of Orai3 in the activation mechanisms of human muscle reserve cells

Lieu: via Zoom

Intervenant: Axel TOLLANCE, laboratoire de la Pre Maud FRIEDEN

Résumé: Understanding how skeletal muscle is able to regenerate is a key issue to develop new strategies for the treatment of skeletal myopathies. A key step of muscle regeneration is the activation of muscle stem cells. Axel TOLLANCE in collaboration with the other researchers from Dr. Maud FRIEDEN laboratory is exploring in vitro the role of calcium in the activation of reserve muscle stem cells.

 

Ether lipids, sphingolipids, and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

Lieu: via Zoom

Intervenant: Flore SINTUREL, laboratoire de la Dre Charna DIBNER

Résumé: Type 2 diabetes is a serious metabolic disorder diagnosed as an increase in blood glucose levels. However, type 2 diabetes is a very heterogenous disease and many factors contribute to the development of this disease. Flore SINTUREL in collaboration with other researchers from Dr. Charna DIBNER laboratory is exploring lipid patterns in different patient profiles to identify biomarker candidates for the characterization of type 2 diabetes.