Evénements

Séminaires passés 2022

20 DEC 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Ilaria COCCHIARARO, laboratoire de la Pre Perrine CASTETS

Résumé: A better understanding of degradation processes, such as autophagy, may open new avenues for the treatment of several muscle diseases. Ilaria COCCHIARARO from Prof. Perrine CASTETS’s laboratory investigates the role of the protein VMA21 in muscle dysfunction in order to better understand the mechanisms leading to the X-linked myopathy with excessive autophagy.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Alexey KOVAL, laboratoire du Pr Vladimir KATANAEV

Résumé: Triple negative breast cancer is a disproportionately deadly cancer with few available therapies. In this cancer, Wnt signaling pathway is dysregulated and finding agents targeting the FZD receptors of this pathway may improve therapeutical approaches. Alexey KOVAL in collaboration with other researchers from Prof. Vladimir KATANAEV’s laboratory has identified the first ever selective FZD inhibitor with anti-cancer properties in vitro and in vivo.

 

13 DEC 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Axelle BOUCHE , laboratoire du Pr Didier HANNOUCHE

Résumé: -

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Tahir IDRIS, laboratoire du Pr Marc CHANSON

Résumé: Cystic fibrosis is a severe genetic disease causing severe respiratory disorders and often leading to life-threatening bacterial infections. Researchers from Marc CHANSON’s laboratory recently discovered that the formation of protein complexes on the surface of the airway epithelium promotes respiratory infections. Tahir IDRIS is exploring the contribution of several signaling pathways in this polarization process with the aim of providing new therapeutic options.

 

6 DEC 2022

Lieu: salle B04.2222

Intervenant: Pryscila SOUSA TEIXEIRA, laboratoire du Pr Roberto COPPARI

Résumé: Despite decades of research on diabetes, insulin deficiency remains a great medical and societal challenge. Daily insulin injections are able to regulate glucose blood concentration, but at the cost of severe secondary complications. Pryscila SOUSA TEIXEIRA in collaboration with other researchers from Roberto COPPARI’s laboratory is investigating how insulin deficiency affects protein production and if the protein S100A9 is capable of restoring it, with the aim of finding alternatives to insulin injections.

 

Lieu: salle B04.2222

Intervenant: Mikhail SAVITSKIY, laboratoire du Pr Vladimir KATANAEV

Résumé: -

 

29 NOV 2022

Lieu: auditoire Boymond B02.2226

Intervenant: Michael BACHMANN, laboratoire du Pr Bernhard WEHRLE-HALLER

Résumé: Understanding better the activation of TGFβ by integrins might help to fight severe diseases such as cancers and fibrotic diseases. Michael BACHMANN in collaboration with the other researchers from Bernhard WEHRLE-HALLER’s laboratory is exploring in vitro the interactions between particulars isoforms of integrin and TGFβ with the aim to develop specific inhibitors of TGFβ.

 

Lieu: auditoire Boymond B02.2226

Intervenant: Raphael MUNOZ, laboratoire du Pr Pierre COSSON

Résumé: A better understanding in the mechanisms of bacterial killing by hosts could help in the fight against infectious diseases. Raphael MUNOZ in collaboration with the other researchers from Prof. Pierre COSSON laboratory is investigating how a cellular model called Dictyostelium discoideum kills bacteria in order to discover new effectors of bacterial killing.

 

22 NOV 2022

Lieu: auditoire Renold B01.2426

Intervenant: Pr Andreas BOLAND, Département de biologie moléculaire, Université de Genève, invité par le Pr Patrick MERALDI

Résumé: -

 

15 NOV 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Marta BALKOTA, laboratoire du Pr Pierre Maechler

Résumé: The tight regulation of the amount of glucose in the blood by the liver, the pancreas but also the brain is an essential process. The GDH enzyme is involved in this regulation, but its exact roles in the brain remain poorly understood. Marta BALKOTA in collaboration with the other researchers from Prof. Pierre MAECHLER’s laboratory is investigating the role of GDH in different areas of the brain and different types of cells with aging.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Karina LINDNER, laboratoire de la Pre Anne-Claude GAVIN

Résumé: ApoE is the main apolipoprotein involved in lipid transport in the brain. If the importance of ApoE in the development of Alzheimer's disease is recognized, the exact molecular mechanisms by which ApoE loads lipids remain elusive. Karina LINDNER in collaboration with the other researchers from Prof. Anne-Claude GAVIN’s laboratory is exploring the role of different isoforms of ApoE in brain lipid metabolism with a particular emphasis on one type of brain cells, the astrocytes.

 

8 NOV 2022

Lieu: salle B04.2222

Intervenant: Camille RABESAHALA DE MERITENS, laboratoire du Pr Nicolas DEMAUREX

Résumé: Neutrophils are a key component of the immune system. Calcium is essential to their functioning, but the implication of the store operated calcium entry (SOCE) pathway and its associated proteins remains unclear. Camille RABESAHALA DE MERITENS in collaboration with the other researchers from Prof. Nicolas DEMAUREX’s laboratory is investigating the role that STIM proteins involved in SOCE play in calcium neutrophil functioning and calcium oscillations.

 

Lieu: salle B04.2222

Intervenant: Juliette SIMONIN, laboratoire du Pr Marc CHANSON

Résumé: Cystic fibrosis is a genetic disease leading to multiple symptoms. Associated respiratory infection by Pseudomonas aeruginosa is a major cause of mortality. Juliette SIMONIN in collaboration with the other researchers from Prof. Marc CHANSON laboratory is investigating how the presence of liquid at the surface of airways promotes airway epithelial integrity.

 

1 NOV 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Matija TRICKOVIC, laboratoire du Pr Mirko TRAJKOVSKI

Résumé: Gut microbiome symbiotically affects the functioning of our body and might provide novel therapeutic targets for metabolic diseases. Matija TRICKOVIC in collaboration with other researchers from Prof. Mirko TRAJKOVSKI’s group is investigating the gut microbiome at the subspecies level. Their recent in silico analyses allowed them to detect subspecies potentially involved in type 2 diabetes and obesity.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Amit KUMAR, laboratoire de la Pre Miriam STOEBER

Résumé: Opioid receptors are a common target for pain relief. Drugs targeting these receptors can, however, cause serious side effects and a better understanding of opioid drug action may enable the development of safer therapeutics. Amit KUMAR, in collaboration with other researchers from Miriam STOEBER’s laboratory, has engineered a new nanobody that modulates opioid receptor function and now aims to understand its precise interaction with opioid receptors and its potential to mitigate some of the side effects of opioid drugs.

 

25 OCT 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Ennio SILVESTRI, laboratoire du Pr Patrick MERALDI

Résumé: Cell division events are tightly synchronized to allow faithful segregation of chromosomes into the two daughter cells. The protein Aurora-A plays many different functions during cell division, but the molecular mechanisms by which its deregulation can lead to the development of cancer are not yet fully understood. Ennio SILVESTRI in collaboration with other researchers from Patrick MERALDI’s laboratory has discovered that both Aurora-A localization and timing of its localization are essential to ensure proper cell division.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Yan ZHOU, laboratoire du Pr Pierre MAECHLER

Résumé: With the climate change crisis, many humans are changing their diet from animal to plant proteins. However, the effects of these changes on metabolism remain not fully understood. Yan ZHOU in collaboration with other researchers from Prof. Pierre MAECHLER’s laboratory is exploring the role of dietary protein source on liver metabolism, with a particular focus on a key enzyme in protein metabolism, the glutamate dehydrogenase.

 

18 OCT 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Jayasimman RAJENDRAN, laboratoire de la Pre Perrine CASTETS

Résumé: Deciphering the response of skeletal muscle to denervation is of major importance to understand muscle decline in neurodegenerative diseases or aging. Jayasimman RAJENDRAN, in the group of Prof. Perrine CASTETS, investigates changes in gene expression occurring within the first hours after nerve injury in the different cell types present in muscle. Using single nucleus RNA sequencing (snRNAseq), he showed that nuclei of muscle fibers respond differently to nerve injury, depending on their location within the cell, and he identified key genes primarily triggered by denervation. 

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Joseph ODDY, laboratoire du Pr Pierre COSSON

Résumé: Understanding better the mechanisms of bacterial killing by hosts might help to fight infectious diseases. Joseph ODDY in collaboration with the other researchers from Prof. Pierre COSSON’s laboratory is investigating how a unicellular model called Dictyostelium discoideum kills bacteria. Researchers were able to discover potential effectors of bacterial killing and confirm the ability to break down proteins of one of them, CPRD.

 

4 OCT 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Cecilia JIMENEZ-SANCHEZ, laboratoire de la Pre Charna DIBNER

Résumé: Diabetes is a serious metabolic disease characterized by the alteration of pancreatic ß-cells involved in insulin secretion and glucose regulation. Cecilia JIMENEZ-SANCHEZ in collaboration with other members of Prof. Charna Dibner’s and Pierre Maechler’s laboratory has identified new lipids associated with the loss of pancreatic ß-cells whose function is largely unknown. Researchers aim now to decipher the exact role they play in glucose regulation.

 

27 SEPT 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Claudie BIAN, laboratoire du Pr Pierre COSSON

Résumé: Single-pass transmembrane proteins are a very common type of proteins involved in many processes, such as cell adhesion, migration and growth. However, the mechanisms involved in their correct localisation, in particular at the Golgi apparatus, remain not clear. Claudie BIAN in collaboration with other researchers from Prof. Pierre COSSON’s laboratory is trying to determine how the orientation of a protein or the composition of its different parts play a role in its localisation.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Monika GJORGJIEVA, laboratoire du Pr Michelangelo FOTI

Résumé: -

 

23 SEPT 2022, 10:30

Lieu:  auditoire Reverdin B02.2526

Intervenant: Prof. Daniel DICKINSON, Department of Molecular Biosciences, University of Texas, Austin invité par la Pre Monica GOTTA

Résumé: -

 

Lieu:  auditoire Reverdin B02.2526

Intervenant: Dr. Josana RODRIGUEZ, Faculty of Medical Sciences, Newcastle upon Tyne, invitée par la Pre Monica GOTTA

Résumé: -

 

20 SEPT 2022

Lieu: auditoire Boymond B02.2226

Intervenant: Eloïse DUCREY, laboratoire du Pr Patrick MERALDI

Résumé: Cancer is a leading cause of death in the world, but current treatments based on one single molecule often cause resistance and severe side effects. Eloïse DUCREY in collaboration with other researchers from the laboratories of Prof. Patrick MERALDI’s and Prof. Patrycja NOWAK is exploring the potential of C2, a four-drug combination, to treat colorectal cancer. Their recent experiments on several cell lines suggest that the drug combination is efficient, yet acts via an unexpected mechanism.

 

Lieu: auditoire Boymond B02.2226

Intervenant: Aleksandar ARSOVIC, laboratoire du Pr Mirko TRAJKOVSKI

Résumé: Adipose tissue is a multifunctional tissue, present in two types in our body: white, which stores excess of fat and brown, which generates heat under challenging environmental conditions. The browning of white adipose tissue is a rising therapeutic strategy in the context of obesity. Using single-cell approaches, such as single-nucleus RNA sequencing and spatial transcriptomics, Aleksandar ARSOVIC in collaboration with other researchers from Prof. Mirko TRAJKOVSKI’s laboratory discovered novel genes involved in browning, whose exact role they are currently studying.

 

13 SEPT 2022

Lieu: salle B04.2222 & Zoom

Intervenant: Pr Miguel ANGEL VALVERDE,  Laboratoire de Physiologie Moléculaire, Université Pompeu Fabra, Barcelone, Espagne, invité par le Pr Nicolas DEMAUREX

Résumé: -

 

6 SEPT 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Gonzalo SOLIS, laboratoire du Pr Vladimir KATANAEV

Résumé: G protein-coupled receptors (GPCRs) are essential for many physiological functions and their dysfunction can lead to severe diseases. Gonzalo SOLIS in collaboration with other researchers from Prof. Vladimir KATANAEV’s laboratory is exploring the role of Gαo, the major neuronal subunit of G protein, in pediatric encephalopathies. Their recent in vitro experiments suggest that the interaction of Gαo with the Ric-8 protein may contribute to the severity of the disorder observed in patients.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Giorgio RAMADORI, laboratoire du Pr Roberto COPPARI

Résumé: -

 

30 AOÛT 2022

Lieu: auditoire Reverdin B02.2526

Intervenant: Axel TOLLANCE, laboratoire de la Pre Maud FRIEDEN

Résumé: Understanding how skeletal muscle is able to regenerate is a key issue to develop new strategies for the treatment of skeletal myopathies. A key step of muscle regeneration is the activation of muscle stem cells. Axel TOLLANCE in collaboration with the other researchers from Prof. Maud FRIEDEN’s laboratory investigates the role of calcium in the activation of reserve muscle stem cells. They discovered that the protein Orai3, involved in the store operated calcium entry, contributes to muscle stem cell activation, but independently from calcium. They are now exploring the role of several partners of Orai3 to decipher the mechanisms involved.

 

Lieu: auditoire Reverdin B02.2526

Intervenant: Emmanuel SOMM, laboratoire du Pr François JORNAYVAZ

Résumé: -

 

28 JUIN 2022

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Kevin ASSOUMOU, laboratoire de la Prof. Miriam STOEBER

Résumé: -

 

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Xin ZHANG, laboratoire du Prof. Vladimir KATANAEV

Résumé: -

 

21 JUIN 2022

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Grégoire ARNOUX, laboratoire du Prof. Eric FERAILLE

Résumé: Chronic kidney disease is a growing global health concern that leads to renal fibrosis and loss of renal function. The progression of this severe disease is exacerbated by reduced blood vessel density. Grégoire ARNOUX in collaboration with other researchers from Prof. Eric FERAILLE’s laboratory is exploring with different in vivo models the potential of the enzyme 11βHSD1 to promote blood vessel growth in the kidney and slow down the progression toward end-stage kidney disease.

 

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Gloria URSINO, laboratoire du Prof. Roberto COPPARI

Résumé: -

 

14 JUIN 2022

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Imen AYADI, laboratoire du Prof. Pierre COSSON

Résumé: Pseudomonas aeruginosa is a bacterium known for its antibiotic resistance and responsible of severe infections. Understanding by which exact mechanisms it can be killed might help to develop new therapeutic strategies. Imen AYADI in collaboration with other researchers from Pierre COSSON laboratory is exploring with Dictyostelium discoideum as a model some of the mechanisms involved in intracellular and extracellular killing.

 

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Mayis KABA, laboratoire du Prof. Nicolas DEMAUREX

Résumé: Phagocytosis is a fundamental mechanism essential for immunity and tissue functioning. During phagocytosis, membrane contact sites between phagosomes and endoplasmic reticulum take place. Mayis KABA in collaboration with other researchers from Prof. Nicolas DEMAUREX laboratory is exploring the role played by phosphatidylinositol transfer proteins both at these membrane contact sites and in phagosomes.

 

7 JUIN 2022

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Jérémy KESSLER, laboratoire du Prof. Bernhard WEHRLE-HALLER

Résumé: Transforming growth factors β (TGFβ) are dimeric proteins involved in the development of tissues and their steady-state. Two isoforms, TGFβ2 and TGFβ3, are of particular importance for muscle tissue, but their exact role and mechanism of action are not fully understood. Jérémy Kessler in collaboration with other researchers from Bernhard WEHRLE-HALLER’s laboratory is exploring their configuration, function and activation mechanism in vitro.  

 

31 MAI 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Prof. Michael ZIMMERMANN, Structural and Computational Biology Unit, EMBL, Allemagne, invité par la Prof. Anne-Claude GAVIN

Résumé: -

 

24 MAI 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Jiabin XU, laboratoire du Prof. Vladimir KATANAEV

Résumé: Clofazimine is an approved drug to treat leprosy. It appears that clofazimine inhibits the Wnt signaling pathway, a pathway important for stem cell maintenance and tissue regeneration and hijacked in several cancers. Jiabin XU in collaboration with other researchers from Vladimir KATANAEV’s laboratory is exploring the potential of clofazimine against Wnt-dependent cancers such as triple negative breast cancer, and against SARS-CoV-2.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Otmane LAMRABET, laboratoire du Prof. Pierre COSSON

Résumé: -

 

17 MAI 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Adriano PIZZELLA, laboratoire de la Prof. Monica GOTTA

Résumé: Environmental stress causes cells to form aggregates called stress granules, but the mechanisms of their formation and function remain unclear. Adriano PIZZELLA together with the other researchers from Monica GOTTA’s laboratory is investigating in C. elegans embryos the mechanisms by which the PQN-59 protein contributes to the assembly of stress granules.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Haiping WANG, laboratoire du Prof. Mirko TRAJKOVSKI

Résumé: Temperature may play a role in the development of certain cancers, such as melanoma. Understanding better how temperature influences tumor growth can provide new therapeutic applications to restrain cancer progression. Haiping WANG together with the other researchers from Mirko TRAJKOVSKI’s laboratory, is exploring the role played by gut microbiota and fat in the response of tumors to warm exposure.

 

10 MAI 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Stéphane KOENIG, laboratoire de la Prof. Maud FRIEDEN

Résumé: Muscle fatigue can occur acutely after intense physical exercise or more chronically, for example during ageing. Stéphane KOENIG in collaboration with the other researchers from Maud FRIEDEN laboratory is exploring the role of the STIM1L protein in calcium signaling and muscle fatigue. Their recent experiments with a new mouse model revealed that the absence of STIML increases muscle fatigue at a certain age.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Thierry BRUN, laboratoire du Prof. Pierre MAECHLER

Résumé: In the long term, an excessive intake of nutrients can lead to a failure of the beta-cells from the pancreas, giving rise to diabetes. Thierry BRUN and researchers from Pierre MAECHLER’s laboratory are exploring the effect of sugar and fat on beta-cells. They have identified an extracellular ATP signalling pathway important for the response of beta-cells. They are now studying the role of several components of this pathway that could represent future therapeutic targets.

 

5 MAI 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Prof. Tommaso PATRIARCHI, Institut de pharmacologie et toxicologie, Université de Zurich, invité par la Prof. Miriam STOEBER

Résumé: -

 

3 MAI 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Alexandre THOMAS, laboratoire du Prof. Patrick MERALDI

Résumé: During cell division, chromosomes are duplicated and equally distributed between two new cells. Their segregation relies on centrosomes which must also be duplicated to organize the network of microtubules that pull apart chromosomes. Alexandre THOMAS in collaboration with other researchers from Patrick MERALDI laboratory is carrying out microscopy experiments to determine the role of age and the number of centrosomes in the regulation of microtubule stability.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Xènia CRESPO, laboratoire du Prof. Pierre COSSON

Résumé: Understanding how immune cells kill bacteria is a key issue for developing antibacterial effectors capable of killing antibiotic-resistant bacteria. Xènia CRESPO in collaboration with the other researchers from Prof. Pierre COSSON laboratory is identifying some of the proteins involved in intracellular bacterial killing and degradation using a unicellular model called Dictyostelium discoideum.

 

26 AVR 2022

Lieu: auditoire Adolphe Franceschetti C150 et Zoom

Intervenant: Melis COLAKOGLU, laboratoire du Prof. Mirko TRAJKOVSKI

Résumé: Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration.  Warmth exposure (34°C) has been recently shown to have a protective role on bone loss. The research team of Prof. Mirko TRAJKOVSKI has also shown that transplantation of the warm-adapted gut microbiota reproduces these warmth-induced bone effects. Melis COLAKOGLU in collaboration with other researchers in the laboratory is investigating the role of the gut microbiota on bone strength and glucose metabolism in postmenopausal mice.

 

Lieu: auditoire Adolphe Franceschetti C150 et Zoom

Intervenant: Adama SIDIBE, laboratoire du Prof. Bernhard WEHRLE-HALLER

Résumé: Wound healing requires interactions between cells and their extracellular environment, such as fibronectin fibers. Acetylation of integrins on the cell surface is involved in this process, but some of the mechanisms remain unknown. Adama SIDIBE in collaboration with the other researchers from Bernhard WEHRLE-HALLER’s laboratory is studying regulatory mechanisms that influence integrin β1 acetylation and fibronectin synthesis.

 

19 AVR 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Felix RENAUDIN, laboratoire du Prof. Didier HANNOUCHE

Résumé: -

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Yonika LARASATI, laboratoire du Prof. Vladimir KATANAEV

Résumé: Pediatric encephalopathies are rare, but severe diseases that still lack treatments. Impaired transmission of signals by G proteins plays a role in the progression and severity of these pathologies. Yonika LARASATI in collaboration with other researchers from Prof. Vladimir KATANAEV laboratory tested hundreds of compounds and discovered a molecule that can potentially restore G protein signaling in pediatric encephalopathies.

 

12 AVR 2022 - 11h

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Olivia CATTANEO, laboratoire de la Prof. Perrine CASTETS

Résumé: Aging often leads to muscle wasting and loss of strength. However, the cellular mechanisms involved remain poorly understood. Olivia CATTANEO, from Prof. Perrine CASTETS laboratory, is investigating the role of the CtBP1 protein in the maintenance of the synapse connecting motoneurons to muscles, and its contribution to muscle deterioration.

 

Lieu: auditoire Reverdin B02.2526 et Zoom

Intervenant: Raquel FIRNKES, laboratoire du Prof. Roberto COPPARI

Résumé: The protein FKBP10 has been recently highlighted as a promising therapeutic target against lung cancer by the laboratory of Roberto COPPARI. Raquel FIRNKES in collaboration with the other researchers from this team is now establishing the relevance of this protein in the fight against another cancer, colorectal cancer. Results from their in vitro and in vivo experiments are encouraging and further support investigation on the role of FKBP10 in colorectal cancer.

 

12 APR 2022 - 10h

Lieu: auditoire Alex‐F. Müller A250 et Zoom

Intervenant: Prof. Tiago Gil Oliveira, Life and Health Sciences Research Institute, School of Medicine, University of Minho, Portugal , invited by Prof. Anne-Claude Gavin

Résumé: -

 

7 AVR 2022 - 14h

Lieu: salle B04.2222

Intervenant: Alessandro SARTORI, Institute of Molecular Cancer Research, Université de Zurich, invité par les Prof. Monica GOTTA & Prof. Patrick MERALDI

Résumé: -

 

29 MARS 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Prof. Gerald SCHWANK, Institut de Pharmacologie et Toxicologie, Université de Zurich, invité par le Prof. Mirko TRAJKOVSKI

Résumé: -

 

28 MARS 2022

Lieu: salle A04.2906

Intervenant: Erik GRIFFIN, Department of Biological Sciences, Dartmouth College, USA, invité par la Prof. Monica GOTTA

Résumé: -

 

22 MARS 2022

Lieu: auditoire A-F Muller A250 et Zoom

Intervenant: Elena DORIA, laboratoire du Prof. Patrick MERALDI

Résumé: The faithful segregation of chromosomes in two daughter cells relies on a network of microtubules that bind the chromosomes and pull them apart. Elena DORIA in collaboration with other researchers from Prof. Patrick MERALDI’s group is exploring the role of microtubule-binding proteins in this process. Their experiments reveal that proteins that bind to one end of microtubules are able to influence not only that end, but also the other.

 

Lieu: auditoire A-F Muller A250 et Zoom

Intervenant: Loann LAUBRY, laboratoire de la Prof. Maud FRIEDEN

Résumé: Calcium is a key element involved in the regulation of many cellular processes. Thestore operated calcium entry (SOCE) pathway is of particular importance for muscles. Loann LAUBRY in collaboration with other researchers from Maud FRIEDEN’s laboratory is exploring the role of different isoforms of a protein called STIM1 in the SOCE pathway, at the beginning of muscle formation and during their maturation.

 

15 MARS 2022

Lieu: B04.2222 et Zoom

Intervenant: Laure GALLAY, laboratoire du Prof. Didier HANNOUCHE

Résumé: Skeletal muscle inflammation regeneration relies on muscle stem cells, which allow the full repair of muscle. Laure GALLAY, in collaboration with other researchers from Prof. Didier HANNOUCHE’s laboratory, is exploring the involvement of muscle stem cells in different types of muscle autoimmune diseases called acquired idiopathic inflammatory myopathies.

 

Lieu: B04.2222 et Zoom

Intervenant: Vincent BERWEILER, laboratoire du Prof. Mirko TRAJKOVSKI

Résumé: -

 

8 MARS 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Mikhail KRYUCHKOV, laboratoire du Prof. Vladimir KATANAEV

Résumé: Insects build microscopic structures on their surface, called nanocoatings. Understanding how there are built may provide new therapeutic avenues. Mikhail KRYUCHKOV in collaboration with other researchers from Prof. Vladimir KATANAEV’s laboratory has developed a process to produce nanocoatings in vitro. They are now exploring further the mechanisms involved in their formation.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Alexandre PROLA, laboratoire de la Prof. Perrine CASTETS

Résumé: Muscles are affected in many pathological conditions, such as aging. However, the mechanisms leading to muscle decline remain often unknown. Alexandre PROLA, in the laboratory of Prof. Perrine CASTETS, investigates the role of local calcium fluxes in the maintenance of the synapse connecting neurons to muscles and the contribution of calcium-associated signaling pathways in sensing the loss of innervation, following nerve injury or spontaneous denervation, such as in aging.

 

7 MAR 2022, 14h

Lieu: auditoire Boymond B02.2226

Intervenant: Prof. Matthias PETER, Institute of Biochemistry ETH Zurich, invité par la Prof. Monica GOTTA

Résumé: -

 

4 MARS 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Dr Rémi Mounier, Institut NeuroMyogène du CNRS, France, invité par le Dr Thomas Laumonier

Résumé: -

 

3 MARS 2022

Lieu: auditoire C150 et Zoom

Intervenant: Prof. Timo OTONKOSKI, Faculté de Médecine de l'Université de Helsinki, Finlande, invité par le Prof. Pierre MAECHLER

Résumé: -

 

1 MARS 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Cédric CASTROGIOVANNI, laboratoire du Prof. Patrick MERALDI

Résumé: Cell division is a tightly synchronized machinery that allows the faithful segregation of chromosomes in two daughter cells. To separate equally the chromosomes, microtubules bind to them at kinetochores and pull them apart. Cédric CASTROGIOVANNI in collaboration with other researchers from Patrick MERALDI’s laboratory uncovered that microtubules binding to chromosomes contain a particular zone, the mixed-nucleotide zone, which is important for their dynamic equilibrium and for the segregation of chromosomes.

 

22 FÉV 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Thomas VERISSIMO, laboratoire de la Prof. Sophie DE SEIGNEUX

Résumé: Chronic kidney disease affects about 10% of the adult population. New therapeutic strategies are needed as this disease is a leading cause of death. Thomas VERISSIMO in collaboration with other researchers from Prof. Sophie DE SEIGNEUX’s laboratory studies the role of a specific receptor in kidney fibrosis and chronic kidney disease progression.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Alexandra BONDAZ, laboratoire du Prof. Bernhard WEHRLE-HALLER

Résumé: Glioblastoma is one of the most common and aggressive forms of brain cancer. Finding new therapeutic approaches is essential, as the chances of survival for patients are very low. Alexandra BONDAZ in collaboration with other researchers from the laboratories of Prof. Bernhard WEHRLE-HALLER and Prof. Denis MIGLIORINI explores the potential of targeting the C-KIT oncogene and its role on the tumor microenvironment.

 

15 FÉV 2022

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Claudie BIAN, laboratoire du Prof. Pierre COSSON

Résumé: Single-pass transmembrane proteins are a very common type of proteins involved in many processes, such as cell adhesion, migration and growth. However, the mechanisms involved in their correct localisation, in particular at the Golgi apparatus, remain not clear. Claudie BIAN in collaboration with other researchers from Prof. Pierre COSSON’s laboratory is trying to determine how the orientation of the protein or the length and degree of hydrophobicity of its part inserted into the membrane play a role in its localization.

 

Lieu: auditoire Boymond B02.2226 et Zoom

Intervenant: Cédric BOUDOU, laboratoire du Prof. Vladimir KATANAEV

Résumé: The Wnt signaling pathway is dysregulated in many cancers and the discovery of agents targeting this pathway could improve therapeutic approaches. Cédric BOUDOU in collaboration with other researchers from Prof. Vladimir KATANAEV is looking for small molecules that can selectively target the upstream part of this pathway and provide new treatment options with fewer side effects.

 

8 FÉV 2022

Lieu: Zoom

Intervenant: Juliette SIMONIN, laboratoire du Prof. Marc CHANSON

Résumé: Cystic fibrosis is a genetic disease leading to multiple symptoms. Associated respiratory infection by Pseudomonas aeruginosa is a major cause of mortality. Juliette SIMONIN in collaboration with the other researchers from Prof. Marc CHANSON laboratory is investigating the cellular mechanisms by which airway surface liquid protects airways against P. aeruginosa.

 

Lieu: Zoom

Intervenant: Amado CARRERAS SUREDA, laboratoire du Prof. Nicolas DEMAUREX

Résumé: -

 

1 FÉV 2022

Lieu: Zoom

Intervenant: Victoria VON GLASENAPP, laboratoire de la Prof. Monica GOTTA

Résumé: -

 

Lieu: Zoom

Intervenant: Larissa VAN EK, laboratoire de la Prof. Anne-Claude GAVIN

Résumé: Maintaining a balanced composition of lipids in membranes is important for many cell functions and a dysregulation of this equilibrium is involved in many diseases ranging from obesity to Alzheimer’s disease. Lipid transfer proteins play an essential role in this process. Larissa VAN EK in collaboration with other researchers from Prof. Anne-Claude GAVIN laboratory is exploring their mechanisms of action and their interactions with cellular metabolism.

 

18 JAN 2022

Lieu: Zoom

Intervenant: Daria IVANOVA, laboratoire du Prof. Patrick MERALDI

Résumé: Understanding cell division is a key issue in overcoming primary microcephaly, a genetic disorder caused by the absence of the protein WDR62 and resulting in impaired brain development. Daria IVANOVA in collaboration with other researchers from Prof. Patrick MERALDI’s group is investigating whether lagging chromosomes caused by a loss of WDR62 can induce DNA damage and cell division arrest.

 

Lieu: Zoom

Intervenant: Mikhail SAVITSKIY, laboratoire du Prof. Vladimir KATANAEV

Résumé: G protein-coupled receptors (GPCRs) are essential for many physiological functions. Their dysfunction can lead to severe diseases, such as encephalopathies. Mikhail SAVITSKIY in collaboration with other researchers from Prof. Vladimir KATANAEV laboratory is developing a new fly model to understand the role of Gαo, a particular subunit of G protein, in a specific encephalopathy where this protein is involved.

 

11 JAN 2022

Lieu: Zoom

Intervenant: Zoé VALBRET, laboratoire de la Prof. Miriam STOEBER

Résumé: G protein-coupled receptors GPCR are involved in many physiological processes and targeted by a third of drugs on market. Unraveling the molecular details of their signal transduction is key for developing safer medications, e.g. for the treatment of pain or heart problems. Zoé VALBRET in collaboration with other researchers from Prof. Miriam STOEBER’s laboratory is studying GPCR action with nanobodies, small antibody fragments that are able to detect the activation of GPCRs in living cells.

 

Lieu: Zoom

Intervenant: Ali SASSI, laboratoire du Prof. Eric FERAILLE

Résumé: Control of the reabsorption of filtered water and minerals, such as sodium and potassium is essential to maintain an adequate balance of body liquids. The fine-tuning of this balance is performed in the kidneys along nephron segments, through transcellular transport (across cells) and paracellular transport (between cells through tight junctions). While the transcellular mechanisms have been extensively studied, the paracellular mechanisms remain poorly understood. Ali SASSI in collaboration with other researchers from Pr. Eric FERAILLE’s laboratory is exploring the role played by claudins, key components of tight junctions, in the paracellular permeability of a specific segment of the nephron, the renal collecting duct.