Groupes de recherche

[998] Voies de signalisation oncogéniques

De la recherche fondamentale à la découverte de médicaments

La signalisation intracellulaire régit de nombreuses activités cellulaires dans des conditions normales comme pathologiques. Mes recherches portent sur la voie de signalisation Wnt/Frizzled conservée au cours de l'évolution, cruciale pour le développement de l'organisme, mais qui joue également un rôle important chez l'adulte en régulant la prolifération des cellules souches, la régénération des tissus, la formation des synapses et, lorsqu'elle est mal activée, le cancer. Dans le contexte du cancer, les organes les plus sensibles à la suractivation de cette voie de signalisation sont le côlon, le sein ou encore le foie.

L’idée de développer un traitement pharmacologique régulant de manière ciblée de la voie Wnt fait figure de "Saint-Graal" pour les nombreux chercheurs impliqués dans le développement de molécules  anticancéreuses. Cependant, ce traitement s’est révélé jusqu'à présent insaisissable, et seulement quelques thérapies ciblant le Wnt ont atteint la phase initiale d’essais cliniques.

Etablir de nouveaux paradigmes permettant la mise au point de médicaments ciblant le Wnt ainsi que de nouveaux composants moléculaires de la voie Wnt est donc essentiel pour proposer de nouvelles cibles thérapeutiques et faire progresser ce domaine de la biomédecine, et c’est à cela que s’emploie mon laboratoire.

Parmi les éléments impliqués dans la signalisation Wnt récemment découverts par mon équipe, certains s’avèrent être des cibles thérapeutiques prometteuses. Les multiples angles d’attaque de mon laboratoire contre la voie Wnt dans le cancer ont permis de développer un portefeuille sans cesse croissant de médicaments candidats de signalisation anti-Wnt, qui sont à différents stades de développement. Combiner recherche fondamentale et translationnelle s’avère donc nécessaire pour produire de nouvelles découvertes sur les mécanismes de signalisation cellulaire, et, in fine, permettre de développer nouveaux médicaments contre le cancer.

Publications

Full publication list, grouped as a) original articles; b) reviews; c) book chapters; d) patents and applications; e) published conference proceedings; numbered through all the four groups. “*” indicates senior authorship. ResearcherID:F-9480-2014. ORCID ID: 0000-0002-7909-5617 .

Original articles

93. Ahmed K, Koval A, Xu J, Katanaev* VL. Preclinical Profiling of the Wnt-targeting Compound Clofazimine as an Anti-TNBC Agent. Cancer Research, submitted.

92. Shaw HV, Koval A, Katanaev* VL. A High-Throughput Assay Pipeline for Specific Targeting of Frizzled GPCRs in Cancer. Invited chapter to: Methods in Cell Biology, vol. 149 / G Protein-Coupled Receptors, 2nd Edition, Part B. In press. DOI: 10.1016/bs.mcb.2018.08.006.

91. KovalA, Pieme CA, Queiroz EF, Ragusa S, Ahmed K, Blagodatski A, Wolfender JL, Petrova TV, Vladimir L. Katanaev* VL. Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts. (2018) Cancer Letters, 435: 110-120. DOI: 10.1016/j.canlet.2018.08.003.

90. Büscher TH, Kryuchkov M, Katanaev VL, Gorb SN. Versatility of Turing patterns potentiates rapid evolution in tarsaladhesive microstructures of stick and leaf insects (Phasmatodea). (2018) Journal of the Royal Society Interface, 15: 20180281. DOI: 10.1098/rsif.2018.0281.

89. Koval A, Ahmed K, Katanaev* VL. Dramatic dysbalancing of the Wnt pathway in breast cancers. (2018) Scientific Reports, 8:7329. DOI: 10.1038/s41598-018-25672-6.

88. Katanaev VL, Egger-Adam D, Tomlinson A. Antagonistic PCP Signaling Pathways in the developing Drosophila eye. (2018) Scientific Reports, 8:5741. DOI:10.1038/s41598-018-24053-3.

87. Keshelava A, Solis GP, Hersch M, Koval A, Kryuchkov M, Bergmann S, Katanaev* VL. High capacity in G protein-coupled receptor signaling. (2018) Nature Communications, 9: 876. DOI: 10.1038/s41467-018-02868-y.

86. Zhuge W, Chen R, Katanaev V, Dong X, Zia K, Sun X, Dai X, Bao M, Shen X, Liang G. Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. (2018) Cancer Letters, 412: 46-58. DOI: 10.1016/j.canlet.2017.10.006.

85. Olivon F, Allard PM, Koval A, Righi D, Genta-Jouve G, Neyts J, Apel C, Pannecouque C, Nothias LF, Cachet X, Marcourt L, Roussi F, Katanaev V, Touboul D, Wolfender JL, Litaudon M. Bioactive natural products prioritization using massive multiinformational molecular networks. (2017) ACS Chemical Biology, 12(10): 2644-51. DOI: 10.1021/acschembio.7b00413.

84. Blagodatski A, Cherepanov V, Koval A, Kharlamenko VI, Khotimchenko YS, Katanaev* VL. High-throughput targeted screening in triple-negative breast cancer cells identifies Wnt-inhibiting activities in Pacific brittle stars. (2017) Scientific Reports, 7:11964. DOI: 10.1038/s41598-017-12232-7.

83. Kryuchkov M, Lehmann J, Schaab J, Cherepanov V, Blagodatski A, Fiebig M, Katanaev* VL. Alternative moth-eye nanostructures: antireflective properties and composition of dimpled corneal nanocoatings in silk-moth ancestors. (2017) Journal of Nanobiotechnology, 15:61. DOI: 10.1186/s12951-017-0297-y.

82. Solis GP, Bilousov O, Lüchtenborg AM, Koval A, Lin C, Katanaev* VL. Golgi-resident Gαo promotes protrusive membrane dynamics. (2017) Cell, 170 (5): 939-55. DOI: 10.1016/j.cell.2017.07.015.

81. Kryuchkov M, Lehmann J, Schaab J, Fiebig M, Katanaev* VL. Antireflective nanocoatings for UV-sensation: the case of predatory owlfly insects. (2017) Journal of Nanobiotechnology, 15:52. DOI: 10.1186/s12951-017-0287-0.

80. Ansermet C, Moor MB, Centeno G, Auberson M, Hu DZ, Baron R, Nikolaeva S, Haenzi B, Katanaeva N, Gautschi I, Katanaev VL, Rotman S, Koesters R, Schild L, Pradervand S, Bonny O, Firsov D. Renal Fanconi syndrome and hypophosphatemic rickets in mice deficient for retroviral receptor XPR1 in the nephron. (2017) Journal of the American Society of Nephrology, 28(4): 1073-8. DOI: 10.1681/ASN.2016070726. Best paper of the year by the Swiss Society of Nephrology.

79. Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev* VL, Jho EH. NLK phosphorylates and potentiates YAP activity by regulating interaction with 14-3-3 and nuclear localization. (2017) EMBO Reports, 18(1): 61-71. DOI: 10.15252/embr.201642683. News & Views in EMBO Reports: 18(1): 3-4. Covered by EMBO Encounters, 35:19. Graded as “Recommended” by the Faculty of 1000 Biology, with the F1000 Article Factor 2.0.

78. Shrivastava S, Jeengar MK, Thummuri D, Koval A, Katanaev VL, Marepally S, Naidu VGM. Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial– mesenchymal transition. (2017) BioFactors, 43(2): 152-69. DOI: 10.1002/biof.1315

77. Koval A, Ahmed K, Katanaev* VL. Inhibition of Wnt Signaling and Breast Tumor Growth by the Multi-purpose Drug Suramin through Suppression of Heterotrimeric G Proteins and Wnt Endocytosis. (2016) Biochemical Journal, 473: 371-81.

76. Pouly D, Chenaux S, Martin V, Babis M, Koch E, Katanaev VL, Gachon F, Staub O. USP2-45 is a circadian clock output effector regulating calcium absorption at the post-translational level. (2016) PLoS ONE, 11: e0145155.

75. Lüchtenborg AM, Purvanov V, Melnik BS, Becker S, Katanaev* VL. Mode of interaction of the Gαo subunit of heterotrimeric G proteins with the GoLoco1 motif of Drosophila Pins is determined by guanine nucleotides. (2015) Biosci. Rep. 35: e00271.

74. Hülsbusch N, Solis GP, Katanaev VL, Stuermer C. Reggie-1/Flotillin-2 regulates integrin trafficking and focal adhesion turnover via Rab11a. (2015) European Journal of Cell Biology, 94(11): 531-45.

73. Blagodatski A, Sergeev A, Kryuchkov M, Lopatina Y, Katanaev* VL. A diverse set of Turing nanopatterns coat corneae across insect lineages. (2015) Proc. Natl. Acad. Sci. U.S.A., 112(34): 10750-5.

72. Sergeev A, Timchenko AA, Kryuchkov M, Blagodatski A, Enin GA, Katanaev* VL. Origin of order in bionanostructures. (2015) RSC Advances, 5: 63521-7.

71. Lüchtenborg AM, Katanaev* VL. Lack of evidence of the interaction of the Abeta peptide with the Wnt signaling cascade in Drosophila models of Alzheimer's disease. (2014) Molecular Brain, 7:81.

70. Lüchtenborg AM, Solis GP, Egger-Adam D, Lin C, Koval A, Blanchard MG,Kellenberger S, Katanaev* VL. Heterotrimeric Go protein links Wnt-Frizzled signaling with Ankyrins to regulate the neuronal microtubule cytoskeleton. (2014) Development, 141(17): 3399-409.

69. Blagodatski A, Kryuchkov M, Sergeev A, Enin GA, Katanaev* VL. Under- and over-water halves of Gyrinidae beetle eyes harbor different corneal nanocoatings providing adaptation the water and air environments. (2014) Scientific Reports 4:6004.

68. Bilousov O, Koval A, Keshelava A, Katanaev* VL. Identification of novel elements of the Drosophila blisterome sheds light on potential pathological mechanisms of several human diseases. (2014) PLoS ONE 9: e101133.

67. Galkina OL, Sycheva A, Blagodatskiy A, Kaptay G, Katanaev VL, Seisenbaeva GA, Kessler VG, Agafonov AV. The Sol-Gel Synthesis of Cotton/TiO2 Composites and their Antibacterial Properties. (2014) Surface and Coatings Technology, 253: 171-9.

66. Lin C, Koval A, Tishchenko S, Gabdulkhakov A, Tin U, Solis G, Katanaev* VL. Double suppression of the Galpha protein activity by RGS proteins. (2014) Molecular Cell, 53(4): 663-71.

65. Ignatious Raja JS, Katanayeva N, Katanaev* VL, Galizia CG. Go/i beta-gamma subunits contribute to Drosophila melanogaster olfactory receptor signaling. (2014) European Journal of Neuroscience 39: 1245-55.

64. Koval AV, Vlasov P, Shichkova P, Khunderyakova S, Markov Y, Panchenko J, Volodina A, Kondrashov FA, Katanaev* VL. Anti-Leprosy Drug Clofazimine Inhibits Growth of Triple-Negative Breast Cancer Cells via Inhibition of Canonical Wnt Signaling. (2014)  Biochemical Pharmacology 87(4): 571-8.

63. Lin C, Katanaev* VL Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity. (2013) PLoS ONE 8: e76885.

62. Solis GP, Hülsbuscha N, Radon Y, Katanaev VL, Plattner H, Stuermer CA. Reggies/flotillins associate with the tubulo-vesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking. (2013) Molecular Biology of the Cell 24(17): 2689-702.

61. Solis G, Lüchtenborg AM, Katanaev* VL. Wnt secretion and gradient formation. (2013) International Journal of Molecular Sciences 14: 5130-45.

60. Tishchenko S, Gabdulkhakov A, Tin U, Kostareva O, Lin C, Katanaev VL. Crystallization and preliminary X-ray diffraction studies of Drosophila melanogaster Gαo-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036. (2013) Acta Crystallographica Section F 69: 61-4.

59. Bilousov OO, Katanaev VL, Kozeretska IA. The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent. (2013) Cytology and Genetics 47: 77-81.

58. Bilousov OO, Katanaev VL, Kozeretska IA. Miniature as a hypothetical regulatory protein of the Bursicon/Rickets signaling cascade in the wing epithelia of Drosophila melanogaster.(2012) Biopolymers and Cell 28: 288-91.

57. Kim WT, Kim H, Katanaev VL, Ishitani T, Han JK, Jho EH. Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. (2012) EMBO Journal 31(16): 3384-97. Editorial in EMBO Journal, 31: 3377-9.

56. Bilousov OO, Kozeretska IA, Katanaev* VL. Role of the gene miniature in Drosophila wing maturation. (2012) Genesis 50: 525-33.

55. Kryuchkov M, Katanaev* VL, Enin GA, Sergeev A, Timchenko AA, Serdyuk IN. Analysis of micro- and nano-structures of the corneal surface of Drosophila and its mutants by atomic force microscopy and optical diffraction. (2011) PLoS ONE 6: e22237.

54. Koval A, Katanaev* VL. Wnt3a Stimulation Elicits G Protein-Coupled Receptor Properties of Mammalian Frizzled Proteins. (2011) Biochemical Journal 433: 435-40. Graded as “Must read” by the Faculty of 1000 Biology, with the F1000 Article Factor 8.0.

53. Purvanov V, Koval A, Katanaev* VL. A direct and functional interaction between the trimeric G protein Go and Rab5 in G protein-coupled receptor signaling. (2010) Science Signaling 3: ra65. Editorial in Science Signaling, 3: pe43.

52. Katanayeva N, Kopein D, Portmann R, Hess D, Katanaev* VL. Competing activities of trimeric G proteins in Drosophila wing maturation. (2010) PLoS ONE 5: e12331. Graded as “Recommended” by the Faculty of 1000 Biology, with the F1000 Article Factor 6.0.

51. Egger-Adam D, Katanaev* VL. The trimeric G protein Go inflicts a double impact on Axin in the Wnt/Frizzled signaling pathway. (2010) Developmental Dynamics 239: 168-83. Journal cover.

50. Koval A, Kopein D, Purvanov V, Katanaev* VL. Eu-GTP as a general non-radioactive substitute for [35S]GTPγS in high-throughput G protein studies. (2010) Analytical Biochemistry 397: 202-7.

49. Kopein D, Katanaev* VL. Drosophila GoLoco-protein Pins is a target of Gαo-mediated G protein-coupled receptor signaling. (2009) Molecular Biology of the Cell 20: 3865-77. Journal cover.

48. Katanaev* VL, Buestorf S. Frizzled Proteins are bona fide G Protein-Coupled Receptors. (2009) Preprint available from Nature Precedings http://hdl.handle.net/10101/npre.2009.2765.1

47. Katanaev* VL, Solis GP, Hausmann G, Buestorf S, Katanayeva N, Schrock Y, Stuermer CA, Basler K. Reggie-1/Flotillin-2 Promotes Secretion of the Long-Range Signaling Forms of Wingless and Hedgehog in Drosophila. (2008) EMBO Journal 27: 509-21. Graded as “Must read” by the Faculty of 1000 Biology, with the F1000 Article Factor 8.0.

46. Katanaev* VL, Chornomorets MP. Kinetic diversity in G protein-coupled receptor signaling. (2007) Biochemical Journal 401: 485-97.

45. Katanaev VL, Tomlinson A. Multiple Roles of a Trimeric G Protein in Drosophila Cell Polarization. (2006) Cell Cycle 5: 2464-72. Journal cover.

44. Katanaev VL, Tomlinson A. Dual roles for the trimeric G-protein Go in asymmetric cell division in Drosophila. (2006) Proc. Natl. Acad. Sci. U.S.A. 103: 6524-9. Editor’s choice in Science, 312: 817.

43. Katanaev VL, Ponzielli R, Sémériva M, Tomlinson A. Trimeric G-protein-dependent Frizzled signaling in Drosophila. (2005) Cell 120: 111-22. Editorial in Cell, 120: 11-14; graded as “Exceptional” by the Faculty of 1000 Biology, with the F1000 factor 17.0.

42. Galli C, Coen MC, Hauert R, Katanaev VL, Groning P, Schlapbach L. Creation of nanostructures to study the topographical dependency of protein adsorption. (2002) Colloids and Surfaces B 26: 255-67.

41. Galli C, Coen MC, Hauert R, Katanaev VL, Wymann MP, Groning P, Schlapbach L. Protein adsorption on topographically nanostructured titanium. (2001) Surface Science 474: L180-4.

40. Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP. Central role for the G protein- coupled PI3Kγ in inflammation. (2000) Science 287: 1049-53. Editorials in Science, 287: 982-983 and Nature, 404: 135-137.

39. Katanaev VL, Wymann MP. Microquantification of cellular and in vitro actin by rhodamine phalloidin fluorescence enhancement. (1998) Analytical Biochemistry 264: 185-90.

38. Katanaev VL, Wymann MP. GTPγS-induced actin polymerisation in vitro: ATP- and phosphoinositide- independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor. (1998) Journal of Cell Science 111: 1583-94.

37. Katanaev VL, Spirin AS, Reuss M, Siemann M. Formation of bacteriophage MS2 infectious units in a cell-free translation system. (1996) FEBS Letters 397: 143-8.

36. Katanaev VL, Kurnasov OV, Spirin AS. Viral Qbeta RNA as a high expression vector for mRNA translation in a cell-free system. (1995) FEBS Letters 359: 89-92.

Review articles

35. Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev* VL. Medicinal mushrooms as an attractive new source of natural compounds for future anticancer therapy. (2018) Oncotarget, 9 (49): 29259-74. DOI: 10.18632/oncotarget.25660.

34. Solis GP, Katanaev* VL. Gαo Encephalopathies: Plasma Membrane vs. Golgi functions. (2018) Oncotarget, 9 (35): 23846-7. DOI: 10.18632/oncotarget.22067.

33. Ahmed K, Shaw HV, Koval A, Katanaev* VL. A second Wnt for old drugs: drug repositioning against Wnt-dependent cancers. (2016) Cancers, 8 (7), 66; DOI: 10.3390/cancers8070066.

32. Blagodatski A, Poteryaev D, Katanaev* VL. Targeting the Wnt Pathway for Therapies. (2014) Molecular and Cellular Therapies, 2:28.

31. Katanaev VL. Prospects of targeting Wnt signaling in cancer. (2014) Journal of Pharmacology and Toxicology Research, 1: 1-3.

30. Koval A, Katanaev* VL. Platforms for High-Throughput Screening of Wnt/Frizzled Antagonists. (2012) Drug Discovery Today 17(23-24): 1316-22.

29. Katanaev* VL, Kryuchkov M. Drosophila eye as the model system to study signal transduction involved in ontogenesis and pathogenesis. (2011) Biochemistry (Moscow) 76: 1556-81.

28. Koval A, Purvanov V, Egger-Adam D, Katanaev* VL. Yellow Submarine of the Wnt/Frizzled Signaling: Submerging from the G Protein Harbor to the Targets. (2011) Biochemical Pharmacology 82(10): 1311-9.

27. Blagodatski A, Katanaev* VL. Technologies of directed protein evolution in vivo. (2011) Cellular and Molecular Life Sciences 68(7): 1207-14.

26. Katanaev* VL. The Wnt/Frizzled GPCR signaling pathway. (2010) Biochemistry (Moscow) 75: 1428-34.

25. Egger-Adam D, Katanaev* VL. Trimeric G protein-dependent signaling by Frizzled receptors in animal development. (2008) Frontiers in Bioscience 13: 4740-55.

24. Katanaev* VL. Signal transduction in neutrophil chemotaxis. (2001) Biochemistry (Moscow) 66: 351-68.

23. Wymann MP, Pirola L, Katanaev VL, Bulgarelli-Leva G. Phosphoinositide 3-kinase signaling - no lipids. (1999) Biochemical Society Transactions 27: 629-34.

Book chapters

22. Kryuchkov M, Blagodatski A, Cherepanov V, Katanaev* VL. Arthropod corneal nanocoatings: diversity, mechanisms, and functions. (2018) Invited book chapter to: Functional Surfaces in Biology III of the Springer Thematic Series Biologically Inspired Systems. Editors: Gorb E, Gorb S., ISBN 978-3-319-74144-4. DOI: 10.1007/978-3-319-74144-4_2.

Patents and applications

21. Katanaev VL, Kryuchkov M. Insect corneal type nanocoatings. European patent application EP18175103.3, filed 30.08.2018.

20. Katanaev VL, Koval A. Novel class of inhibitors of the Wnt signaling pathway. European patent application EP18159649.5, filed 02.03.2018.

19. Katanaev VL, Koval A, Blagodatski A. Wnt7a polypeptides and their use. European patent application 20140718, filed 18.07.2014.

18. Katanaev VL. Cell-free assay product and method of use thereof for measuring activity of frizzled receptors. US patent 8,119,354, February 21, 2012.

Journal-published conference proceedings

17. Ham H, Lamborn I, Zhang Y, Berchiche Y, Koval A, Jing H, Mandl JN, Happel C, Masutani E, McElwee , Matthews HF, Druey KM, Mustillo PJ, Germain RN, Sakmar T, Katanaev V, Helen Su. Dominant-activating Gαi2 mutations cause human immunodeficiency and autoimmunity by causing defective leukocyte migration and altered T cell activation. (2017) Journal of Immunology 198 (S1): 59.16.

16. Ansermet C, Moor M, Centeno G, Auberson M, Hu D, Barron R, Nikolaeva S, Haenzi B, Katanaeva N, Gautschi I, Katanaev V, Rotman S, Koesters R, Schild L, Pradervand S, Bonny O, Firsov D. Deletion of Xenotropic and Polytropic Retrovirus Receptor 1 in mouse nephron causes renal Fanconi syndrome and hypophosphatemic rickets (2017) FASEB Journal 31(S1): 857.9.

15. Olivon F, Allard PM, Koval A, Leyssen P, Dumontet V, Roussi F, Cachet X, Touboul D, Wolfender JL, Katanaev V, Litaudon M. Can molecular networking be a powerful tool to target specific bioactive scaffolds? Case study of New Caledonian Euphorbiaceae species. (2016) Planta Medica 81(S01): S381.

14. Koval A, Ahmed K, Katanaev* V. Old friends are better to trust: Repositioning clofazimine and suramin against triple-negative breast cancer. (2016) Annals of Oncology 27(S6): 1543P.

13. Mizrahi-Meissonnier L, Zaguri R, Rhodes E, Katanaev V, Minke B, Sharon D. Molecular, physiological and morphological effects of DHDDS knockdown in photoreceptors of Drosophila. (2015) Investigative Ophthalmology & Visual Science 56(7): 5441.

12. Katanaev* VL. Wnt signaling as a target of anti-breast cancer drug discovery. (2014) Anticancer Research 34(12):7481.

11. Blagodatski A, Sova V, Gorovoy P, Usov A, Katanaev* V. Novel activators and inhibitors of the Wnt signaling pathway from medicinal plants. (2014) Planta Medica 80(16): SL29.

10. Luechtenborg AM, Egger-Adam D, Lin C, Blanchard M, Kellenberger S, Katanaev* V. The heterotrimeric G-protein go links wingless signaling with Ankyrin2 in neuromuscular junctions. (2012) Journal of Neurogenetics 26:20.

9. Kim WT, Kim HJ, Katanaev V, Ishitani T, Han JK, Jho EH. Bi-modal regulation of Wnt signaling pathway by DP1. (2010) Differentiation 80: S56.

8. Egger-Adam D, Katanaev* V. Direct and functional interaction of the trimeric G protein Go with Axin, a negative regulator of the Wnt/Frizzled signaling pathway. (2009) European Journal of Cell Biology 88(S1): 50-1.

7. Kopein D, Katanaev* VL. Drosophila GoLoco-protein Pins interacts with G alpha o to transduce G-protein coupled receptor signaling. (2009) European Journal of Cell Biology 88(S1): 55.

6. Purvanov V, Katanaev* VL. Direct interaction of a small and a trimeric G protein. (2009) European Journal of Cell Biology 88(S1): 16-7.

5. Buestorf S, Katanaev* VL. The G protein-coupled receptor identity of the frizzled proteins. (2009) Cell Communication and Signaling 7(S1): A19.

4. Kopein DS, Diederichs K, Katanaev* VL. Drosophila GoLoco-protein Pins as a target of Gαo-mediated G protein coupled receptor signaling.(2009) Cell Communication and Signaling 7(S1): A104.

3. Katanaev VL, Ponzielli R, Semeriva M, Tomlinson A. Transduction of frizzled signaling by a heterotrimeric GTP-binding protein in Drosophila. (2003) Developmental Biology 259(2): 518-9.

2. Katanaev VL, Hirsch E, Bulgarelli-Leva G, Wymann MP. Signalling by G protein coupled phosphoinositide-3 kinase γ - neutrophil responses in PI3K γ knock-out mice. (2000) The biology and pathology of innate immunity mechanisms, Vol. 479, p.305. Keisari, Y., and Ofek, I. (Eds.), Kluwer Academic/Plenum Publishers, New York.

1. Katanaev VL, Wymann MP. Membrane-associated guanine nucleotide exchange factor and cytosolic Rho-family protein signal to actin polymerisation in vitro in an ATP- and phosphoinositide-independent manner. (1998) European Journal of Haematology 60: 348.