Research Groups

[991] Neuropsychiatry and biomarkers of Alzheimer's Disease

The research group led by Julius Popp has expertise in the field of biomarker discovery and clinical and translational research in early stages of Alzheimer’s disease. The group’s research activities focus on the earliest biological and clinical changes related to neurodegeneration, cognitive decline and delirium in older age. In particular, these activities aim to:

  1. Identify and validate biomarkers for prediction, early detection and differential diagnosis of cognitive impairment and related behavioral psychological symptoms
  2. Better understand the molecular mechanisms of Alzheimer's disease and related neurodegenerative diseases, including pathomecanisms related to neuroinflammation, stress, sleep, and metabolic changes.
  3. Identify risk and protective factors of cognitive decline and delirium to assess risk and develop approaches to prevention and treatment of cognitive impairment and neuropsychiatric syndromes.

The group is involved in the population based CoLaus/PsycoLaus study and collaborates to several European and international multicenter studies in the fields of neuropsychiatry and biomarker discovery.

Publications

In Press

MattssonN, Groot C, Jansen W, Landau S, Villemagne V, Engelborghs S, Mintun M, MD; Alberto Lleo A, Molinuevo JM, Jagust W, Frisoni GM, Ivanoiu A, Chetelat G, Prabhakar S, Resende de Oliveira C, Rodrigue KM, Kornhuber A, Wallin A,; Klimkowicz-Mrowiec A, Popp J, The Amyloid Biomarker Study group; Vandenberghe R, David J. Brooks, MD, PhD; Tormod Fladby, MD, PhD; Christopher C. Rowe, MD, PhD; Alexander Drzezga, MD, PhD; Marcel M. Verbeek, PhD; Marie Sarazin, MD, PhD; David A. Wolk, MD; Adam S. Fleisher, MD, MAS; William E. Klunk, MD, PhD; Duk L. Na, MD, PhD; Páscual Sanchez-Juan, MD, PhD; Dong Young Lee, MD, PhD; Agneta Nordberg, MD, PhD; Magda Tsolaki, MD, PhD; Vincent Camus, MD, PhD; Juha O. Rinne, MD, PhD; Anne M. Fagan, PhD; Gil D. Rabinovici, MD; Oskar Hansson, MD, PhD; Wiesje M. van der Flier, PhD; Philip Scheltens, MD, PhD; Pieter Jelle Visser, MD, PhD; & Rik Ossenkoppele.
Prevalence of the Apolipoprotein E ε4 allele in amyloid-β positive subjects across the spectrum of Alzheimer’s disease. Alzheimer's & Dementia. 2018, in press

Ten Kate M, Alberto Redolfi A,  Peira E, Bos I, Vos S, Vandenberghe R, Gabel S, Schaeverbeke J, Scheltens P, Blin O, Richardson JC, Bordet R, Wallin A, Eckerstrom C, Molinuevo JL, Engelborghs S, Van Broeckhoven C, Martinez-Lage P, Popp J, Tsolaki M, Verhey F, Baird AL, Legido-Quigley C, Bertram L, Dobricic V, Zetterberg H, Lovestone S, Streffer J, Bianchetti S, Novak G, Revillard J, Gordon M, Xie Z, Wottschel V, Frisoni G, Visser PJ, Barkhof F. MRI predictors of amyloid pathology: results from the EMIF-AD multimodal biomarker discovery study. Alzheimers Res Ther. 2018, in press

 Schaub C, von Gunten A, Morin D, Wild P, Gomez P*, Popp J*.The effect of hand massage on stress and agitation: a pilot study in hospitalized patients with dementia. Applied Psychophysiology and Biofeedback. 2018, in press.(Gomez and Popp: equal contribution)

Gallart-Ayala H, Konz I, Mehl F, Teav T, Oikonomidi A, Peyratout A, van der Velpen V; Popp J*, Ivanisevic J*. A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects. Analytica Chimica Acta. 2018 in press
*Popp and Ivanisevic: equal contribution

Bos I, Vos S, Vandenberghe R, Scheltens P, Engelborghs S, Frisoni S, Molinuevo JL, Wallin A, Lleo A, Popp J, Martinez-Lage P, Baird A, Dobson R, Legido-Quigley C, Dertram L, Sleegers K, ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Visser PJ. European Medical Information Framework for Alzheimer’s disease (EMIF-AD): The Multimodal Biomarker Discovery Study. Alzheimers Res Ther. 2018, in press

Dayon L, Wojcik J, Galindo AL, Corthésy J, Cominetti O, Oikonomidi A, Henry H, Migliavacca E, Bowman GM, Popp J. Alzheimer disease pathology and the cerebrospinal fluid proteome.Alzheimers Res Ther. 2018, in press

Bowman GM, Dayon L, Kirkland R, Wojcik J, Peyratout G, Severin I, Henry H, Oikonomidi A, Migliavacca E, Bacher M, Popp J. Blood-brain barrier breakdown, neuroinflammation and cognitive decline in older adults. Alzheimer's & Dementia. 2018, in press

Other publications