Labidi-Galy Lab

Intidhar Labidi-Galy

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Dr. Intidhar Labidi-Galy

Pathogenesis and precision medicine in breast and ovarian cancer, Lab Leader

CMU - 6th floor, Room A06.2910.c
+41 22 379 56 40
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Intidhar obtained a MD from the University of Tunis and trained as a medical oncologist between Tunisia and France before pursing with a PhD in immuno-oncology at University of Lyon and a fellowship in oncology at Centre Leon Berard (Lyon, France). In 2011, she earned a Fullbright Arthur Sachs/Harvard University and a Fondation de France scholarships and moved to Boston for a post-doctoral fellowship in Dr Ronny Drapkin’s lab at Dana Farber Cancer Institute of Harvard University. She worked with Dr Drapkin on pathogenesis of high-grade serous ovarian carcinoma. End of 2014, she was appointed as junior investigator at the Faculty of Medicine of Geneva. She received in 2017 a SNSF Ambizione grant and started her own research group in CRTOH in the fall of 2017.

Publications

2020

2019

2018

2017

  • Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, Hruban CA, Hirsch MS, Lin DI, Schwartz L, Maire CL, Tille JC, Bowden M, Scharpf RB, Kurman R, Wang TL, Shih IM, Karchin R, Drapkin R, Velculescu VE. High grade serous ovarian carcinomas originate in the fallopian tube. Nature Communications 2017 Oct 23;8(1):1093. https://www.ncbi.nlm.nih.gov/pubmed/29061967
  • Ballestro A, Bedognetti D, Ferraioli D, Labidi-Galy SI, Leo E, Murai J, Pommier Y, Tsantoulis P, Vellone VG, Zoppoli G. Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer. J Transl Med 2017 Oct 2;15(1):199. https://www.ncbi.nlm.nih.gov/pubmed/28969705
  • Vuillemier A, Labidi-Galy SI. Screening of ovarian cancer: Not for tomorrow. Rev Med Suisse. 2017 May 17;13(563):1039-1041.
  • 2016
  • De Picciotto N, Cacheux W, Roth A, Chappuis PO, Labidi-Galy SI. Ovarian cancer: status of homologous recombination pathway as a predictor of drug response. Crit Rev Oncol Hematol 2016; 101: 50-9. https://www.ncbi.nlm.nih.gov/pubmed/26964893

2015

  • Labidi-Galy SI, Clauss A, Ng V, Duraisamy S, Elias KM, Piao HY, Bilal E, Davidowitz RA, Lu Y, Badalian-Very G, Györffy B, Kang UB, Ficarro S, Ganesan S, Mills GB, Marto JA, Drapkin R. Elafin drives poor outcome in high grade serous ovarian cancers and basal-like breast tumors’. Oncogene 2015; 34(3): 373-83. https://www.ncbi.nlm.nih.gov/pubmed/24469047.

2014

  • Williams KA, Labidi-Galy SI, Terry KL, Vitonis AF, Welch WR, Goodman A, Cramer DW. Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. Gynecol Oncol. 2014 Mar; 132(3):542-50. https://www.ncbi.nlm.nih.gov/pubmed/24462730.
  • Elias KM, Labidi-Galy SI, Vitonis AF, Hornick JL, Doyle LA, Hirsch MS, Cramer DW, Drapkin R. Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms. Gynecol Oncol. 2014 Feb; 132(2):328-33. https://www.ncbi.nlm.nih.gov/pubmed/24342438.

2013

  • Sisirak V, Vey N, Goutagny N, Renaudineau S, Malfroy M, Thys S, Treilleux I, Labidi-Galy SI, Bachelot T, Ménétrier-Caux C, Blay JY, Caux C, and Bendriss-Vermare N. Breast cancer-derived TGF-ß and TNF-α compromise IFN- α production by tumor-associated plasmacytoid dendritic cells. Int J Cancer 2013 133(3):771-8. https://www.ncbi.nlm.nih.gov/pubmed/23389942

2012

  • Péron J, Cropet C, Tredan O, Bachelot T, Ray-Coquard I, Clapisson G, Chabaud S, Philip I, Borg C, Cassier P, Labidi Galy I, Sebban C, Perol D, Biron P, Caux C, Menetrier-Caux C, Blay JY. CD4 lymphopenia to identify end-of-life metastatic cancer patients. Eur J Cancer. 2012; 49(5):1080-9. https://www.ncbi.nlm.nih.gov/pubmed/23246297
  • Sisirak V, Faget J, Gobert M, Treilleux I, Renaudineau S, Poyet G, Labidi-Galy SI, Goddard-Leon S, Durand I, Goutagny N, Le Mercier I, Bachelot T, Ray-Coquard I, Puisieux A, Ménétrier-Caux C, Blay JY, Caux C, Bendriss-Vermare N. Impaired IFN-α production by plasmacytoid dendritic cells favors regulatory T cells expansion that may contribute to breast cancer progression. Cancer Res. 2012 Oct 15; 72(20):5188-97. https://www.ncbi.nlm.nih.gov/pubmed/22836755
  • Manuel M, Tredan O, Bachelot T, Clapisson G, Courtier A, Parmentier G, Rabeony T, Grives A, Perez S, Mouret JF, Perol D, Chabaud S, Ray-Coquard I, Labidi-Galy I, Heudel P, Pierga JY, Caux C, Blay JY, Pasqual N, Ménétrier-Caux C. Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients. Oncoimmunology. 2012 Jul 1; 1(4):432-440. https://www.ncbi.nlm.nih.gov/pubmed/22754761
  • Labidi-Galy SI, Treilleux I, Goddard-Leon S, Combes JD, Blay JY, Ray-Coquard I, Caux C, and Bendriss-Vermare N. Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis. Oncoimmunology. 2012 3 (1): 1-3. https://www.ncbi.nlm.nih.gov/pubmed/22737622

2011

  • Labidi-Galy SI, Sisirak V, Meeus P, Gobert M, Treilleux I, Bajard A, Combes JD, Faget J, Mithieux F, Cassignol A, Tredan O, Durand I, Ménétrier-Caux CCaux C, Blay JY, Ray-Coquard I, Bendriss-Vermare N. Quantitative and functional alterations of plasmacytoid dendritic cell in cancer contribute to immune tolerance. Cancer Res. 2011 Aug 15; 71(16):5423-34. https://www.ncbi.nlm.nih.gov/pubmed/21697280

2006-2010

  • Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C, Le Cesne A, Judson I, Tredan O, Verweij J, Biron P, Labidi I, Guastalla JP, Bachelot T, Perol D, Chabaud S, Hogendoorn PC, Cassier P, Dufresne A, Blay JY; European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res. 2009; 69(13):5383-91. https://www.ncbi.nlm.nih.gov/pubmed/19549917
  • Labidi SI, Ménétrier-Caux C, Chabaud S, Chassagne C, Sebban C, Gargi T, Biron P, Blay JY, Ghesquières H. Serum cytokines in follicular lymphoma. Correlation of TGF-beta and VEGF with survival. Ann Hematol. 2010; 89:25-33. https://www.ncbi.nlm.nih.gov/pubmed/19582455
  • Bachelot T, Le Rhun E, Labidi-Gally I, Heudel P, Gilabert M, Bonneterre J, Pierga JY, Gonçalves A. Systemic treatment of brain metastases from breast cancer: cytotoxic chemotherapy and targeted therapies. Bull Cancer. 2013 Jan 1;100(1):7-14. https://www.ncbi.nlm.nih.gov/pubmed/23305997
  • Peron J, Tredan O, Ray-Coquard I, Bachelot T, Labidi-Galy SI, Favier B, Treilleux I, Guastalla JP. First-line endocrine therapy alone could be a reasonable treatment option for hormone-positive, HER2-positive metastatic breast cancer. Bull Cancer 2012. 2012 Feb 1;99 (2):E18-25. https://www.ncbi.nlm.nih.gov/pubmed/22257781
  • Cassier PA, Labidi-Galy SI, Heudel P, Dutour A, Méeus P, Chelghoum M, Alberti L, Ray-Coquard I, Blay JY. Therapeutic pipeline for soft-tissue sarcoma. Expert Opin Pharmacother. 2011 Nov;12(16):2479-91. https://www.ncbi.nlm.nih.gov/pubmed/21913865
  • Asmane I, Kurtz JE, Bajard A, Guastalla JP, Meeus P, Tredan O, Labidi-Galy I, Moullet I, Ardisson P, Vincent L, Coeffic D, Dufresne A, Bergerat JP, Ray-Coquard I. Bevacizumab plus microtubule targeting agents in heavily pre-treated ovarian cancer patients: a retrospective study. Bull Cancer. 2011 Oct;98(9):80-9. https://www.ncbi.nlm.nih.gov/pubmed/21926034
  • Galy G, Labidi-Galy SI, Perol D, Bachelot T, Ray-Coquard I, Tredan O, Blay JY, Latour JF,JP Guastalla, B Favier. Metastatic breast cancer treated by chemotherapy: Comparison of clinical practice and costs of drugs in two cohorts of patients: 1994-1998 and 2003-2006. Breast Cancer Res Treat. 2011 Jul; 128(1):187-95. https://www.ncbi.nlm.nih.gov/pubmed/21184270
  • Carrabin N, Mithieux F, Meeus P, Trédan O, Guastalla JP, Bachelot T, Labidi-Galy SI, Treilleux I, Rivoire M, Ray-CoquardI. Hyperthermic intraperitoneal chemotherapy (HIPEC) using oxaliplatin for stage IIIC ovarian cancer without adjuvant chemotherapy. Bull Cancer. 2010 Apr; 97(4):E23-32. https://www.ncbi.nlm.nih.gov/pubmed/20202920
  • Galy G, Labidi SI, Tissier F, Combes JD, Auger A, Favier B, Latour JF. Aprepitant for the prevention of cisplatine induced nausea and vomiting: an observational study. Bull Cancer. 2009; 96(2):141-5. https://www.ncbi.nlm.nih.gov/pubmed/19258220
  • Labidi SI, Bachelot T, Ray-Coquard I, Mosbah K, Treilleux I, Fayette J, Favier B, Galy G, Blay JY, Guastalla JP. Bevacizumab and paclitaxel for breast cancer patients with central nervous system metastases: a case series. Clin Breast Cancer. 2009; 9(2):118-21. https://www.ncbi.nlm.nih.gov/pubmed/19433393
  • Cassier PA, Dufresne A, Arifi S, El Sayadi H, Labidi I, Ray-Coquard I, Tabone S, Méeus P, Ranchère D, Sunyach MP, Decouvelaere AV, Alberti L, Blay JY. Imatinib mesilate for the treatment of gastrointestinal stromal tumour. Expert Opin Pharmacother. 2008; 9(7):1211-22. https://www.ncbi.nlm.nih.gov/pubmed/18422477
  • Labidi SI, Sebban C, Ghesquieres H, Virelizier Nicolas E, Pierre Biron. Hepatic veno-occlusive disease after tandem autologous stem cell transplantation conditionned by melphalan. Int J Hematol. 2008; 88(3):291-3. https://www.ncbi.nlm.nih.gov/pubmed/18696182
  • Labidi SI, M’rad K, Mezlini A, Ouarda MA, Combes JD, Ben Abdallah M, Ben Romdhane K, Viens P, Ben Ayed F. Tunisian inflammatory breast cancer in the era of multimodality therapy. Ann Oncol. 2008; 19(3):473-80. https://www.ncbi.nlm.nih.gov/pubmed/18006895
  • Ben Hamida A, Intidhar Labidi S, M’rad K, Charafe-Jauffret E, Ben Arab S, Esterni B, Xerri L, Viens P, Bertucci F, Birnbaum D, Jacquemier J. P-cadherin expression characterizes inflammatory breast cancer. BMC cancer. 2008; 8:28. https://www.ncbi.nlm.nih.gov/pubmed/18230143
  • Labidi SI, Gravis G, Tarpin C, Brun V, Viens P. Medullary thyroid cancer treated by capecitabine. Anticancer Drugs. 2007; 18(7): 831-4. https://www.ncbi.nlm.nih.gov/pubmed/17581307
  • Intidhar Labidi S, Chaabouni AM, Kraiem T, Attia N, Gritli S, El May A, Ben Slimane F. Thyroid carcinoma and Hashimoto thyroiditis. Ann Otolaryngol Chir Cervicofac. 2006; 123(4):175-8. https://www.ncbi.nlm.nih.gov/pubmed/17088704
  • Charaffe-Jaufret E, M’rad K, Intidhar Labidi S, Ben Hamida A, Ben Romdhane K, Ben Abdallah M, Ginestier C, Esterni B, Birnbaum D, Ben Ayed F, Xerri L, Viens P, Mezlini A, Jacquemier J. Inflammatory breast cancers in Tunisia and France show similar immunophenotypes. Breast. 2007; 16: 352-8. https://www.ncbi.nlm.nih.gov/pubmed/17360185
  • Chaabouni AM, Intidhar Labidi S, Kraiem T, Gammoudi A, Ladgham A, Ben Slimane F. Papillary-follicular carcinoma arising in a lingual thyroid. Ann Otolaryngol Chir Cervicofac. 2006; 123(4):199-202. https://www.ncbi.nlm.nih.gov/pubmed/17088708

Lab Members