Aurélien Roux

Publications

2019

  • Faelber, Katja; Dietrich, Lea; Noel, Jeffrey K.; Wollweber, Florian; Pfitzner, Anna-Katharina; Mühleip, Alexander; Sánchez, Ricardo; Kudryashev, Misha; Chiaruttini, Nicolas; Lilie, Hauke; Schlegel, Jeanette; Rosenbaum, Eva; Hessenberger, Manuel; Matthaeus, Claudia; Kunz, Séverine; von der Malsburg, Alexander; Noé, Frank; Roux, Aurélien; van der Laan, Martin; Kühlbrandt, Werner; Daumke, Oliver (2019) Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature 571 (7765) 429-433.
  • Kadosh, Avihay; Colom, Adai; Yellin, Ben; Roux, Aurélien; Shemesh, Tom (2019) The tilted helix model of dynamin oligomers. Proc. Natl. Acad. Sci. USA 116 (26) 12845-12850.
  • Tomba, Caterina; Petithory, Tatiana; Pedron, Riccardo; Airoudj, Aissam; Di Meglio, Ilaria; Roux, Aurélien; Luchnikov, Valeriy (2019) [Inside Back Cover] Cells at Wrinkled Interfaces: LaserAssisted Strain Engineering of Thin Elastomer Films to Form Variable Wavy Substrates for Cell Culture (Small 21/2019). Small 15 (21) 1970113.
  • Riggi, Margot; Bourgoint, Clélia; Macchione, Mariano; Matile, Stefan; Loewith, Robbie; Roux, Aurélien (2019) TORC2 Controls Endocytosis Through Plasma Membrane Tension. J. Cell Biol. 218 (7) 2265.
  • Tomba, Caterina; Petithory, Tatiana; Pedron, Riccardo; Airoudj, Aissam; Di Meglio, Ilaria; Roux, Aurélien; Luchnikov, Valeriy (2019) Laser–Assisted Strain Engineering of Thin Elastomer Films to Form Variable Wavy Substrates for Cell Culture. Small 15 (21) 1900162.
  • Goujon, Antoine; Colom, Adai; Straková, Karolína; Mercier, Vincent; Mahecic, Dora; Manley, Suliana; Sakai, Naomi; Roux, Aurélien; Matile, Stefan (2019) Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum and Lysosome. J. Am. Chem. Soc. 141 (8) 3380-3384.
  • Machado, Sarah; Mercier, Vincent; Chiaruttini, Nicolas (2019) LimeSeg: a coarse-grained lipid membrane simulation for 3D image segmentation. BMC Bioinf. 20 (1) 2.
  • Maechler, Florian A.; Allier, Cédric; Roux, Aurélien; Tomba, Caterina (2019) Curvature Dependent constraints drive remodeling of epithelia. J. Cell Sci. 132 (4) jcs222372.
  • Carlini, Lina; Mahecic, Dora; Kleele, Tatjana; Roux, Aurelien; Manley, Suliana (2019) Membrane bending energy and tension govern mitochondrial division. bioRxiv, Biophys.. [accepted]

2018

  • Riggi, Margot; Niewola-Staszkowska, Karolina; Chiaruttini, Nicolas; Colom, Adai; Kusmider, Beata; Mercier, Vincent; Soleimanpour, Saeideh; Stahl, Michael; Matile, Stefan; Roux, Aurélien; Loewith, Robbie (2018) Decrease in Plasma Membrane Tension Triggers PtdIns(4,5)P2 Phase Separation to Inactivate TORC2. Nat. Cell. Biol. 20 (9) 1043-1051.
  • Colom, Adai; Derivery, Emmanuel; Soleimanpour, Saeideh; Tomba, Caterina; Dal Molin, Marta; Sakai, Naomi; González-Gaitán, Marcos; Matile, Stefan; Roux, Aurélien (2018) A Fluorescent Membrane Tension Probe. Nat. Chem. 10 (11) 1118-1125.
  • Melero, Alejandro; Chiaruttini, Nicolas; Karashima, Takefumi; Riezman, Isabelle; Funato, Kouichi; Barlowe, Charles; Riezman, Howard; Roux, Aurélien (2018) Lysophospholipids Facilitate COPII Vesicle Formation. Curr. Biol. 28 (12) 1950-1958.e6.
  • Kruse, Karsten; Chiaruttini, Nicolas; Roux, Aurélien (2018) Optical control of cytoplasmic flows. Nat. Cell Biol. 20 227-228.
  • Kaksonen, Marko; Roux, Aurélien (2018) Mechanisms of clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 19 313-326.
  • Tanasescu, Radu; Mettal, Ute; Colom, Adai; Roux, Aurélien; Zumbuehl, Andreas (2018) Facile and Rapid Formation of Giant Vesicles from Glass Beads. Polymers 10 (1) 54/1-54/11.
  • Merzouki, Aziza; Malaspinas, Orestis; Trushko, Anastasiya; Roux, Aurélien; Chopard, Bastien (2018) Influence of cell mechanics and proliferation on the buckling of simulated tissues using a vertex model. Nat. Comput. 17 (3) 511-519.

2017

  • Gopaldass, Navin; Fauvet, Bruno; Lashuel, Hilal; Roux, Aurélien; Mayer, Andreas (2017) Membrane scission driven by the PROPPIN Atg18. EMBO J. 36 (22) 3097-3267.
  • Galli, Valentina; Sebastian, Rafael; Moutel, Sandrine; Ecard, Jason; Perez, Franck; Roux, Aurélien (2017) Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab. eLife 23 3483.
  • Hohendahl, Annika; Talledge, Nathaniel; Galli, Valentina; Shen, Peter S; Humbert, Frédéric; De Camilli, Pietro; Frost, Adam; Roux, Aurélien (2017) Structural inhibition of dynamin-mediated membrane fission by endophilin. eLife 14 331.
  • Chiaruttini, Nicolas; Roux, Aurélien (2017) Dynamic and elastic shape transitions in curved ESCRT-III filaments. Curr. Opin. Cell Biol. 47 126-135.
  • Shydlovskyi, Sergii; Zienert, Anke Y.; Ince, Semra; Dovengerds, Christine; Hohendahl, Annika; Dargazanli, Julia M.; Blum, Ailisa; Günther, Saskia D.; Kladt, Nikolay; Stürzl, Michael; Schauss, Astrid C.; Kutsch, Miriam; Roux, Aurélien; Praefcke, Gerrit J. K.; Herrmann, Christian (2017) Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1. Proc. Natl. Acad. Sci. U.S.A 114 (28) E5559-E5568.
  • Roux, Aurélien; Loewith, Robbie (2017) Tensing Up for Lipid Droplet Formation. Dev. Cell 41 (6) 571-572.
  • Mierzwa, Beata E.; Chiaruttini, Nicolas; Redondo-Morata, Lorena; Moser von Filseck, Joachim; König, Julia; Larios, Jorge; Poser, Ina; Müller-Reichert, Thomas; Scheuring, Simon; Roux, Aurélien; Gerlich, Daniel W. (2017) Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. Nat. Cell Biol. 19 (7) 787-798.
  • Zala, Diana; Schlattner, Uwe; Desvignes, Thomas; Bobe, Julien; Roux, Aurélien; Chavrier, Philippe; Boissan, Mathieu (2017) The advantage of channeling nucleotides for very processive functions. F1000Res. 6 724.
  • Zala, Diana; Schlattner, Uwe; Desvignes, Thomas; Bobe, Julien; Roux, Aurélien; Chavrier, Philippe; Boissan, Mathieu (2017) The advantage of channeling nucleotides for very processive functions [version 2]. F1000Research 6 724.
  • Colom, Adai; Redondo-Morata, Lorena; Chiaruttini, Nicolas; Roux, Aurélien; Scheuring, Simon (2017) Dynamic remodeling of the dynamin helix during membrane constriction. Proc. Natl. Acad. Sci. USA 114 (21) 5449-5454.
  • Daumke, Oliver; Roux, Aurélien (2017) Mitochondrial Homeostasis: How Do Dimers of Mitofusins Mediate Mitochondrial Fusion?. Curr. Biol. 27 (9) R353-R356.
  • Jukic, Nebojsa; Redondo-Morata, Lorena; Roux, Aurélien; Scheuring, Simon (2017) Recovery of ESCRT-III Filaments Subjected to Force: An 'Invasive Mode' HS-AFM Study. Biophys. J. 112 (3) 92a.
  • Verolet, Quentin; Dal Molin, Marta; Colom, Adai; Roux, Aurelien; Guénée, Laure; Sakai, Naomi; Matile, Stefan (2017) Twisted Push-Pull Probes with Turn-On Sulfide Donors. Helv. Chim. Acta 100 (2) e1600328.

2016

  • Soleimanpour, Saeideh; Colom, Adai; Derivery, Emmanuel; Gonzalez-Gaitan, Marcos; Roux, Aurelien; Sakai, Naomi; Matile, Stefan (2016) Headgroup Engineering in Mechanosensitive Membrane Probes. Chem. Commun. 52 (100) 14450-14453.
  • Antonny, Bruno; Burd, Christopher; De Camilli, Pietro; Chen, Elizabeth; Daumke, Oliver; Faelber, Katja; Ford, Marijn; Frolov, Vadim A.; Frost, Adam; Hinshaw, Jenny E.; Kirchhausen, Tom; Kozlov, Michael M.; Lenz, Martin; Low, Harry H.; McMahon, Harvey; Merrifield, Christien; Pollard, Thomas D.; Robinson, Phillip J.; Roux, Aurélien; Schmid, Sandra (2016) Membrane fission by dynamin: what we know and what we need to know. EMBO J. 35 (21) 2270-2284.
  • Hohendahl, Annika; Roux, Aurélien; Galli, Valentina (2016) Structural insights into the centronuclear myopathy-associated functions of BIN1 and dynamin 2. J. Struct. Biol. 196 (1) 37-47.
  • Alessandri, Kevin; Feyeux, Maxime; Gurchenkov, Basile; Delgado, Christophe; Trushko, Anastasiya; Krause, Karl-Heinz; Vignjevic, Danijela; Nassoy, Pierre; Roux, Aurélien (2016) A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC). Lab Chip 16 (9) 1593-1604.

2015

  • Chiaruttini, Nicolas; Redondo-Morata, Lorena; Colom, Adai; Humbert, Frédéric; Lenz, Martin; Scheuring, Simon; Roux, Aurélien (2015) Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation. Cell 163 (4) 866-879.
  • Gonzalez-Gaitan, Marcos; Roux, Aurélien (2015) When cell biology meets theory. J. Cell Biol. 210 (7) 1041-1045.
  • Saleem, Mohammed; Morlot, Sandrine; Hohendahl, Annika; Manzi, John; Lenz, Martin; Roux, Aurélien (2015) A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats. Nat. Commun. 6 6249.

2014

2012

  • Morlot, Sandrine; Galli, Valentina; Klein, Marius; Chiaruttini, Nicolas; Manzi, John; Humbert, Frédéric; Dinis, Luis; Lenz, Martin; Cappello, Giovanni; Roux, Aurélien (2012) Membrane Shape at the Edge of the Dynamin Helix Sets Location and Duration of the Fission Reaction. Cell 151 (3) 619-629.
  • Kornmann, Benoît; Roux, Aurélien (2012) Lipids as organizers of cell membranes. EMBO Rep. 13 (8) 667-669.
  • Berchtold, Doris; Piccolis, Manuele; Chiaruttini, Nicolas; Riezman, Isabelle; Riezman, Howard; Roux, Aurélien; Walther, Tobias C.; Loewith, Robbie (2012) Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat. Cell Biol. 14 (5) 542-547.
  • Sorre, Benoît; Callan-Jones, Andrew; Manzi, John; Goud, Bruno; Prost, Jacques; Bassereau, Patricia; Roux, Aurélien (2012) Nature of curvature coupling of amphiphysin with membranes depends on its bound density. Proc. Natl. Acad. Sci. U. S. A. 109 (1) 173-178.

2011

  • Shlomovitz, Roie; Gov, Nir S.; Roux, Aurélien (2011) Membrane-mediated interactions and the dynamics of dynamin oligomers on membrane tubes. New J. Phys. 13 (6) 065008.
  • Chang-Ileto, Belle; Frere, Samuel G.; Chan, Robin B.; Voronov, Sergey V.; Roux, Aurélien; Di Paolo, Gilbert (2011) Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission. Dev. Cell 20 (2) 206-218.

2010

  • Morlot, Sandrine; Lenz, Martin; Prost, Jacques; Joanny, Jean-François; Roux, Aurélien (2010) Deformation of Dynamin Helices Damped by Membrane Friction. Biophys. J. 99 (11) 3580-3588.
  • Roux, Aurélien; Plastino, Julie (2010) Actin takes its hat off to dynamin. EMBO J. 29 (21) 3591-3592.
  • Roux, Aurélien; Koster, Gerbrand; Lenz, Martin; Sorre, Benoît; Manneville, Jean-Baptiste; Nassoy, Pierre; Bassereau, Patricia (2010) Membrane curvature controls dynamin polymerization. Proc. Natl. Acad. Sci. U. S. A. 107 (9) 4141-4146.

2009

  • Lenz, Martin; Morlot, Sandrine; Roux, Aurélien (2009) Mechanical requirements for membrane fission: Common facts from various examples. FEBS Lett. 583 (23) 3839-3846.

2008

  • Roux, Aurélien; Antonny, Bruno (2008) The Long and Short of Membrane Fission. Cell 135 (7) 1163-1165.
  • Krauss, Michael; Jia, Jun-Yong; Roux, Aurélien; Beck, Rainer; Wieland, Felix T.; De Camilli, Pietro; Haucke, Volker (2008) Arf1-GTP-induced Tubule Formation Suggests a Function of Arf Family Proteins in Curvature Acquisition at Sites of Vesicle Budding. J. Biol. Chem. 283 (41) 27717-27723.
  • Frost, Adam; Perera, Rushika; Roux, Aurélien; Spasov, Krasimir; Destaing, Olivier; Egelman, Edward H.; De Camilli, Pietro; Unger, Vinzenz M. (2008) Structural Basis of Membrane Invagination by F-BAR Domains. Cell 132 (5) 807-817.

2007

2006

  • Roux, Aurélien; Uyhazi, Katherine; Frost, Adam; De Camilli, Pietro (2006) GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature 441 (7092) 528-531.

2005

  • Itoh, Toshiki; Erdmann, Kai S.; Roux, Aurelien; Habermann, Bianca; Werner, Hauke; De Camilli, Pietro (2005) Dynamin and the Actin Cytoskeleton Cooperatively Regulate Plasma Membrane Invagination by BAR and F-BAR Proteins. Dev. Cell 9 (6) 791-804.
  • Roux, Aurélien; Cuvelier, Damien; Nassoy, Pierre; Prost, Jacques; Bassereau, Patricia; Goud, Bruno (2005) Role of curvature and phase transition in lipid sorting and fission of membrane tubules. EMBO J. 24 (8) 1537-1545.
  • Jolimaître, Pascale; Roux, Aurélien; Blanpain, Annick; Leduc, Cécile; Bassereau, Patricia; Bourel-Bonnet, Line (2005) Synthesis and preliminary physical applications of a rhodamin-biotin phosphatidylethanolamine, an easy attainable lipid double probe. Chem. Phys. Lipids 133 (2) 215-223.

2004

  • Leduc, Cécile; Campàs, Otger; Zeldovich, Konstantin B.; Roux, Aurélien; Jolimaitre, Pascale; Bourel-Bonnet, Line; Goud, Bruno; Joanny, Jean-François; Bassereau, Patricia; Prost, Jacques (2004) Cooperative extraction of membrane nanotubes by molecular motors. Proc. Natl. Acad. Sci. U. S. A. 101 (49) 17096-17101.
  • Allain, J.-M.; Storm, C.; Roux, Aurélien; Amar, M. Ben; Joanny, Jean-François (2004) Fission of a Multiphase Membrane Tube. Phys. Rev. Lett. 93 (15) 158104.

2003

  • Nizak, Clément; Martin-Lluesma, Silvia; Moutel, Sandrine; Roux, Aurélien; Kreis, Thomas E.; Goud, Bruno; Perez, Franck (2003) Recombinant Antibodies Against Subcellular Fractions Used to Track Endogenous Golgi Protein Dynamics in Vivo. Traffic 4 (11) 739-753.
  • Abaza, Aouatef; Soleilhac, Jean-Marc; Westendorf, Joanne; Piel, Matthieu; Crevel, Isabelle; Roux, Aurélien; Pirollet, Fabienne (2003) M Phase Phosphoprotein 1 Is a Human Plus-end-directed Kinesin-related Protein Required for Cytokinesis. J. Biol. Chem. 278 (30) 27844-27852.

2002

  • Roux, Aurélien; Cappello, Giovanni; Cartaud, Jean; Prost, Jacques; Goud, Bruno; Bassereau, Patricia (2002) A minimal system allowing tubulation with molecular motors pulling on giant liposomes. Proc. Natl. Acad. Sci. U. S. A. 99 (8) 5394-5399.