Sascha Hoogendoorn is a newly appointed tenure-track assistant professor in the department of Organic Chemistry and the NCCR Chemical Biology at the University of Geneva. She received her PhD in Organic Chemistry from the group of professor Herman Overkleeft at the University of Leiden, the Netherlands in 2013. In her PhD work, she used synthetic chemistry to develop receptor-targeting small molecules to accomplish selective cellular entry. She then moved to Stanford University where she worked in the group of professor James Chen as a postdoctoral scholar, and developed a novel CRISPR/Cas9-based screening methodology to study ciliary Hedgehog signaling.
In her lab she uses an interdisciplinary approach to study and perturb cellular signaling, with a particular interest in the primary cilium and the Hedgehog signaling pathway. Her research combines organic chemistry with cell biology and CRISPR/Cas9-based gene editing to develop molecules that enable further dissection and manipulation of ciliary signaling.