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  1. “Ruthenium Lewis Acid Catalyzed Asymmetric 1,3-Dipolar Cycloadditions between N-Methylnitrones and Enals”
    A. Bădoiu, G. Bernardinelli, E.P. Kündig,
    Synthesis 2010, 2207-2212.

N-Methylisoxazolidines are formed in good yields and high regio-, diastereo- and enantioselectivity via asymmetric 1,3-dipolar cycloaddition of nitrones with enals catalyzed by a chiral ruthenium Lewis acid. Electronic effects in the dipole are the key to activation of these substrates for efficient catalysis.

DOI : 10.1055/s-0029-1218788 

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