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Publication 166  


  1. “Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines via Inert C(sp3)-H Activation”
    M. Nakanishi, D. Katayev, C. Besnard, E.P. Kündig,
    CHIMIA 2012, 66, 241-243.

New sterically hindered chiral N-heterocyclic carbene (NHC) ligands were used in palladium catalysis to bring about a highly enantioselective C(sp3)-H activation on the methylene site of a cycloalkane moiety. The intramolecular coupling reaction of a prochiral N-aryl-N-cycloalkyl methyl carbamate required high temperatures (140–160 °C) and afforded highly enantioenriched trans-2,3-fused indolines.

DOI : 10.2533/chimia.2012.241 

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