189. “Asymmetric bromine–lithium exchange: on the importance of both the diamine ligand and the organolithium reagent”
     J. Praz, J. Graff, L. Egger, L. Guénée, S. Wagschal, E.P. Kündig, A. Alexakis,
     Chem. Commun. 2015, 51, 16912-16915.

The asymmetric lithium-bromine exchange is described on a series of prochiral biphenyls. As in many asymmetric organolithium reactions, the chiral ligand (here a diamine) is considered as the enantiocontroling element. We demonstrate herein that the organolithium reagent, which undergoes the exchange, also plays an important role.

DOI : 10.1039/C5CC06548H 

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