82. “Conformationally Stabilized Catalysts by Fluorine Insertion: Tool for Enantioselectivity Improvement”
    A. Quintard, J.-B. Langlois, D. Emery, J. Mareda, L. Guénée, A. Alexakis
    Chem. Eur. J. 2011, 17, 13433-13437.

Frigid cats: The power of conformationally stabilized catalysts is demonstrated. By taking appropriate advantage of fluorine insertion (see scheme), purely conformational catalyst design led to a notable improvement in enantioselectivities from around 70 % to 91-98.5 % ee. The other advantage of this approach is the better understanding of the origin of the stereoselectivity in the given catalytic system.

DOI : 10.1002/chem.201102757 

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