Publication 208

    1. Adriaenssens, L. V.; Estarellas, C.; Vargas Jentzsch, A.; Martínez Belmonte, M.; Matile, S.; Ballester, P. “Quantification of Nitrate-π Interactions and Selective Transport of Nitrate Using Calix[4]pyrroles with Two Aromatic Walls” J. Am. Chem. Soc. 2013, 135, 8324-8330 

Herein we disclose the results of our investigations regarding the interactions between the biologically relevant nitrate oxoanion and several “two-wall” aryl-extended calix[4]pyrroles. There exists a clear relationship between the electronic nature of the aromatic walls of the calix[4]pyrroles and the stability of the nitrate⊂calix[4]pyrrole complex. This suggests that NO3-π interactions have an important electrostatic component. We provide energetic estimates for the interaction of nitrate with several phenyl derivatives. Additionally, we report solid-state evidence for a preferred binding geometry of the nitrate anion included in the calix[4]pyrroles. Finally, the “two-wall” aryl-extended calix[4]pyrroles show excellent activity in ion transport through lipid-based lamellar membranes. Notably the best anion transporters are highly selective for transport of nitrate over other anions.

[open archive unige:28405 • pdf ]