- Anion Transport in Lipid Bilayer Membranes Using Halogen Bonds
Vargas Jentzsch, A.; Matile, S.
in Halogen Bonding in Solution; Huber, S. (Ed.) Wiley, 2021; Chapter 6; p. 195-231
The development of ion transport systems employing halogen bonding for function and structure started less than a decade ago. This line of research was motivated by the intrinsically compatible characteristics of this noncovalent interaction with transmembrane ion transport, leading to a number of macrocyclic and supramolecular approaches to be explored and reported. Amidst more elaborated molecular frameworks, simple perfluoro-1-iodoalkanes have conclusively proven the relevance and suitability of halogen bonding toward this functional application. Indeed, the strength and directionality of the halogen bond, added to a hydrophobic scaffold, were sufficient to enable anion binding and transport across a lipid bilayer membrane. Macrocyclic arrays were advanced to demonstrate multitopic binding and transport, further enlarging the possibilities. Finally, ion channels relying on halogen bonding to enable multi-ion hopping across the membrane have also been reported. These larger structures could be constructed both using covalent and supramolecular approaches and were the most active transporters exploiting halogen bonding.
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