2017

Dell'Aglio E., Boycheva S., Fitzpatrick T.B.: The pseudoenzyme PDX1.2 sustains vitamin B6 biosynthesis as a function of heat stress. Plant Physiology 2017, 174(4):2098-2112. PMID: 28550206.

Mangel N., Fudge J., §Fitzpatrick T.B., Gruissem W., §Vanderschurem H.: Vitamin B1 diversity and characterization of biosynthesis genes in cassava. Journal of Experimental Botany, 2017, 68(13):3351-3363. PMID: 28859374(§ co-corresponding authors)

Van Der Straeten D., Fitzpatrick T.B., De Steur H.: Editorial overview: Biofortification of crops: achievements, future challenges, socio-economic, health and ethical aspects. Current Opinion in Biotechnology 2017, 44:7–10. PMID: 28342725. 

Fudge J., Mangel N., Gruissem W., Vanderschuren H., Fitzpatrick T.B.: Rationalising vitamin B6 biofortification in crop plants. Current Opinion in Biotechnology 2017, 44:130-137. PMID: 28086191.

 

2016

Robinson G. C., Kaufmann M., Roux C., Fitzpatrick T.B.: Structural definition of the lysine swing in Arabidopsis thaliana PDX1: Intermediate channeling facilitating vitamin B6 biosynthesis. Proceedings of the National Academy of Sciences 2016, 113(40):E5821-E5829. PMID: 27647886.

Hofer A., Marques E., Kieliger N., Gatter S.N., Jordi S., Ferrari E., Hofmann M., Fitzpatrick T.B., Hottiger M.O., Jessen H.J.: Chemoselective Dimerization of Phosphates. Organic Letters 2016, 18(13):3222-5. PMID: 27308921.

Martinis J., Gas-Pascual E., Szydlowski N., Crèvecoeur M., Gisler A., Bürkle L., Fitzpatrick T.B.: Long distance transport of thiamine (vitamin B1) is concomitant with that of polyamines in Arabidopsis. Plant Physiology 2016, 171(1):542-53. PMID: 27006489.

Colinas M., Fitzpatrick T.B.: Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity. Plant Signalling and Behaviour 2016, 11(4):e1161876. PMID: 27018849.

Colinas M., Eisenhut M., Tohge T., Pesquera M., Fernie A.R., Weber A.P.M., Fitzpatrick T.B.: Balancing of B6 vitamers is essential for plant development and metabolism in Arabidopsis. Plant Cell 2016, 28(2):439-53. PMID: 26858304. 

 

2015

Li K.T., Moulin M., Mangel N., Albersen M., Verhoeven-Duif N.M., Ma Q., Zhang P., Fitzpatrick T.B., Gruissem W, Vanderschuren H: Increased bioavailable vitamin B6 in field-grown transgenic cassava for dietary sufficiency. Nature Biotechnology 2015, 33(10):1029-32. PMID: 26448082.

Colinas M. & Fitzpatrick T.B.: Natures balancing act: examining biosynthesis de novo, recycling and processing damaged vitamin B metabolitesCurrent Opinion in Plant Biology 2015, 25:98-106. PMID: 26005929.

Boycheva S., Dominguez A., Rolcik J., Boller T. & Fitzpatrick T.B.: Consequences of a deficit in vitamin B6 biosynthesis de novo for hormone homeostasis and root development in Arabidopsis. Plant Physiology 2015, 167(1):102-17. PMID: 25475669.

 

2014

Fitzpatrick T.B. & Thore S.: Complex behavior: from cannibalism to suicide in the vitamin B1 biosynthesis world. Current Opinion in Structural Biology 2014, 29C:34-43. PMID: 25260119.

Colinas M., Shaw H.V., Loubéry S., Kaufmann M., Moulin M. & Fitzpatrick T.B.: A pathway for repair of NAD(P)H in plants. The Journal of Biological Chemistry 2014, 289(21):14692-706. PMID: 24706747.

Boycheva S., Daviet L., Wolfender J.L. & Fitzpatrick T.B.: The rise of operon-like gene clusters in plants. Trends in Plant Science 2014, 19(7):447-59. PMID: 24582794.

Moccand C., Boycheva S., Surriabre P., Tambasco-Studart M., Raschke M., Kaufmann M. & Fitzpatrick T.B.: The pseudoenzyme PDX1.2 boosts vitamin B6 biosynthesis under heat and oxidative stress in Arabidopsis. The Journal of Biological Chemistry 2014, 289(12):8203-16. PMID: 24505140.

 

2013

Coquille S., Roux C., Mehta A., Begley T.P., Fitzpatrick T.B. & Thore S.: High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. Journal of Structural Biology 2013, 184(3):438-44. PMID: 24161603.

Moulin M., Nguyen G.T., Scaife M.A., Smith A.G. & Fitzpatrick T.B.: Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proceedings of the National Academy of Sciences USA 2013, 110(36):14622-7. PMID: 23959877.

Pourcel L., Moulin M. & Fitzpatrick T.B.: Examining strategies to facilitate vitamin B1 biofortification of plants by genetic engineering. Frontiers in Plant Science 2013, 4:160. PMID: 23755056.

Vanderschuren H., Boycheva S., Li K.T., Szydlowski N., Gruissem W. & Fitzpatrick T.B.: Strategies for vitamin B6 biofortification of plants: a dual role as a micronutrient and a stress protectant. Frontiers in Plant Science 2013, 4:143. PMID: 23734155.

Szydlowski N., Bürkle L., Pourcel L., Moulin M., Stolz J. & Fitzpatrick T.B.: Recycling of pyridoxine (vitamin B6) by PUP1 in Arabidopsis. The Plant Journal 2013, 75(1):40-52. PMID: 23551747.

 

2012

Coquille S., Roux C., Fitzpatrick T.B. & Thore S.: The last piece in the vitamin B1 biosynthesis puzzle: structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase. The Journal of Biological Chemistry 2012, 287(50):42333-43. PMID: 23048037.

Fitzpatrick T.B., Basset G.J., Borel P., Carrari F., Dellapenna D., Fraser P.D., Hellmann H., Osorio S., Rothan C., Valpuesta V., Caris-Veyrat C. & Fernie A.R.: Vitamin deficiencies in humans: can plant science help? Plant Cell 2012, 24(2):395-414. PMID: 22374394.

 

2011

Raschke M., Boycheva S., Crevecoeur M., Nunes-Nesi A., Witt S., Fernie A.R., Amrhein N. & Fitzpatrick T.B.: Enhanced levels of vitamin B(6) increase aerial organ size and positively affect stress tolerance in Arabidopsis. The Plant Journal 2011, 66(3):414-432. PMID: 21241390.

Moccand C., Kaufmann M. & Fitzpatrick T.B.: It takes two to tango: defining an essential second active site in pyridoxal 5'-phosphate synthase. PLoS One 2011, 6(1):e16042. PMID: 21283685.

 

2010

Fitzpatrick T.B., Moccand C. & Roux C.: Vitamin B6 biosynthesis: charting the mechanistic landscape. Chembiochem 2010, 11(9):1185-1193. PMID: 20397182.

 

2009

Raschle T., Speziga D., Kress W., Moccand C., Gehrig P., Amrhein N., Weber-Ban E. & Fitzpatrick T.B.: Intersubunit cross-talk in pyridoxal 5'-phosphate synthase, coordinated by the C terminus of the synthase subunit. The Journal of Biological Chemistry 2009, 284(12):7706-7718. PMID: 19074821.

Benabdellah K., Azcon-Aguilar C., Valderas A., Speziga D., Fitzpatrick T.B. & Ferrol N.: GintPDX1 encodes a protein involved in vitamin B6 biosynthesis that is up-regulated by oxidative stress in the arbuscular mycorrhizal fungus Glomus intraradices. New Phytologist 2009, 184(3):682-693. PMID: 19674326.

 

2007

Tambasco-Studart M., Tews I., Amrhein N. & Fitzpatrick T.B.: Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis. Plant Physiology 2007, 144(2):915-925. PMID: 17468224.

Raschle T., Arigoni D., Brunisholz R., Rechsteiner H., Amrhein N. & Fitzpatrick T.B.: Reaction mechanism of pyridoxal 5'-phosphate synthase: detection of an enzyme-bound chromophoric intermediate. The Journal of Biological Chemistry 2007, 282(9):6098-6105. PMID: 17189272.

Raschke M., Burkle L., Muller N., Nunes-Nesi A., Fernie A.R., Arigoni D., Amrhein N. & Fitzpatrick T.B.: Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC. Proceedings of the National Academy of Sciences USA 2007, 104(49):19637-19642. PMID: 18048325.

Fitzpatrick T.B., Amrhein N., Kappes B., Macheroux P., Tews I. & Raschle T.: Two independent routes of de novo vitamin B6 biosynthesis: not that different after all. Biochemical Journal 2007, 407(1):1-13. PMID: 17822383.

 

2006

Titiz O., Tambasco-Studart M., Warzych E., Apel K., Amrhein N., Laloi C. & Fitzpatrick T.B.: PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis. The Plant Journal 2006, 48(6):933-946. PMID: 17227548.

Strohmeier M., Raschle T., Mazurkiewicz J., Rippe K., Sinning I., §Fitzpatrick T.B. & §Tews I.: Structure of a bacterial pyridoxal 5'-phosphate synthase complex. Proceedings of the National Academy of Sciences USA 2006, 103(51):19284-19289. PMID: 17159152. (§ co-corresponding authors)

Gengenbacher M., Fitzpatrick T.B., Raschle T., Flicker K., Sinning I., Muller S., Macheroux P., Tews I. & Kappes B.: Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights. The Journal of Biological Chemistry 2006, 281(6):3633-3641. PMID: 16339145.

 

2005

Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N. & Fitzpatrick T.B.: Vitamin B6 biosynthesis in higher plants. Proceedings of the National Academy of Sciences USA 2005, 102(38):13687-13692. PMID: 16157873.

Raschle T., Amrhein N. & Fitzpatrick T.B.: On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis. The Journal of Biological Chemistry 2005, 280(37):32291-32300. PMID: 16030023.

Morokutti A., Lyskowski A., Sollner S., Pointner E., Fitzpatrick T.B., Kratky C., Gruber K. & Macheroux P.: Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase. Biochemistry 2005, 44(42):13724-13733. PMID: 16229462.

Kitzing K., Fitzpatrick T.B., Wilken C., Sawa J., Bourenkov G.P., Macheroux P. & Clausen T.: The 1.3 Å crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes. The Journal of Biological Chemistry 2005, 280(30):27904-27913. PMID: 15890652.

 

2004

McConkey G.A., Pinney J.W., Westhead D.R., Plueckhahn K., Fitzpatrick T.B., Macheroux P. & Kappes B.: Annotating the Plasmodium genome and the enigma of the shikimate pathway. Trends in Parasitology 2004, 20(2):60-65. PMID: 14747018.

Fitzpatrick T.B., Auweter S., Kitzing K., Clausen T., Amrhein N. & Macheroux P.: Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation. Protein Expression and Purification 2004, 36(2):280-291. PMID: 15249051.

 

2003

Fitzpatrick T.B., Amrhein N. & Macheroux P.: Characterization of YqjM, an Old Yellow Enzyme homolog from Bacillus subtilis involved in the oxidative stress response. The Journal of Biological Chemistry 2003, 278(22):19891-19897. PMID: 12660247.

 

2001

Geyer A., Fitzpatrick T.B., Pawelek P.D., Kitzing K., Vrielink A., Ghisla S. & Macheroux P.: Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma. European Journal of Biochemistry 2001, 268(14):4044-4053. PMID: 11453999.

Fitzpatrick T.B., Killer P., Thomas R.M., Jelesarov I., Amrhein N. & Macheroux P.: Chorismate synthase from the hyperthermophile Thermotoga maritima combines thermostability and increased rigidity with catalytic and spectral properties similar to mesophilic counterparts. The Journal of Biological Chemistry 2001, 276(21):18052-18059. PMID: 11279147.

Fitzpatrick T., Ricken S., Lanzer M., Amrhein N., Macheroux P. & Kappes B.: Subcellular localization and characterization of chorismate synthase in the apicomplexan Plasmodium falciparum. Molecular Microbiology 2001, 40(1):65-75. PMID: 11298276.

 

1999

O'Sullivan D.B., O'Connell T.P., Mahon M.M., Koenig A., Milne J.J., Fitzpatrick T.B. & Malthouse J.P.: 13C NMR study of how the oxyanion pKa values of subtilisin and chymotrypsin tetrahedral adducts are affected by different amino acid residues binding in enzyme subsites S1-S4. Biochemistry 1999, 38(19):6187-6194. PMID: 10320347.

 

1998

Mahon M.M., Gramatikova S.I., Christen P., Fitzpatrick T.B. & Malthouse J.P.: The pyridoxal-5'-phosphate-dependent catalytic antibody 15A9: its efficiency and stereospecificity in catalysing the exchange of the alpha-protons of glycine. FEBS Letters 1998, 427(1):74-78. PMID: 9613603.

Fitzpatrick T.B. & Malthouse J.P.: A substrate-induced change in the stereospecificity of the serine-hydroxymethyltransferase-catalysed exchange of the alpha-protons of amino acids: evidence for a second catalytic site. European Journal of Biochemistry 1998, 252(1):113-117. PMID: 9523719.

Fitzpatrick T.B. & Malthouse J.P.: The effect of histidine-228 on the catalytic efficiency and stereospecificity of the serine hydroxymethyltransferase catalysed exchange of the alpha-protons of amino acids. Biochimica Biophysica Acta 1998, 1386(1):220-226. PMID: 9675289.

 

1997

Malthouse J.P., Fitzpatrick T.B., Milne J.J., Grehn L. & Ragnarsson U.: Enzymatic synthesis of isotopically labelled serine and tryptophan for application in peptide synthesis. Journal of Peptide Science 1997, 3(5):361-366. PMID: 9391911.

 
Plant Biochemistry & Physiology Laboratory
 
Department of Botany and Plant Biology,
University of Geneva,
Quai E. Ansermet 30,
1211-Geneva,
Switzerland

Prof. Teresa Fitzpatrick

Full Professor
Email: theresa.fitzpatrick(at)unige.ch
 Tel: +41 22 379 30 16 (direct)
Tel: +41 22 379 35 52 (secretary)