Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector

Gianluca Boso, Damei Ke, Boris Korzh, Jordan Bouilloux, Norbert Lange and Hugo Zbinden

Biomedical Optics Express, 7, 211 (2016)

Photodynamic therapy (PDT) is a recent technique that can help the treatment of various medical conditions, from skin and prostate cancer to certain bacterial infection. In our recent paper on Biomedical Optics Express we demonstrated that using a practical and efficient InGaAs/InP single-photon detector we developed, we are able to detect the faint luminescence signal ( at 1270 nm) from the decay of singlet-oxygen, the active molecule involved in PDT. This helped quantify the amount of singlet-oxygen produced by new photosensitive drugs developed at the University of Geneva. The technique will also help to better understand the mechanisms of singlet-oxygen in PDT both in-vitro and in-vivo.

photodynamic therapy, PDT, , single photon detector, quantum biology

Experimental setup used to detect the singlet-oxygen luminescence signal produced in different aqueous solutions of photosensitiser. The sample is excited with a 532 nm pulsed laser and the luminescence signal is collected through a confocal scheme.