About the PARKLAT project

Asymmetry of motor symptoms is common in Parkinson's disease, with more than 80% of patients experiencing either predominantly right-sided motor symptoms (RPD) or predominantly left-sided motor symptoms (LPD), reflecting a contralateral hemispheric loss of dopamine in the basal ganglia. This asymmetric process seems to go beyond motor manifestations, differentially affecting non-motor symptoms in patients. Recent studies have indeed evidenced different cognitive and neuropsychiatric phenotypes when comparing patients based on motor symptom asymmetry and physiological markers. The aim of the PARKLAT project is to better understand how motor symptom asymmetry impacts the neuropsychological profile of patients with Parkinson's disease in the early stages of the disease, as well as following subthalamic nucleus deep brain stimulation.

Collaborators

Didier Grandjean
Neuroscience of Emotion and Affective Dynamics Laboratory (NEAD), Department of Psychology and Swiss Center for Affective Sciences, University of Geneva, Switzerland

Florence Le Jeune
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Nuclear Medicine Department, Eugène Marquis Center, Rennes, France

Marc Vérin
‘Behavior and Basal Ganglia’ Research Unit, University of Rennes 1-Rennes University Hospital, Rennes, France
Neurology Department, Pontchaillou Hospital, Rennes University Hospital, Rennes, France

Philippe Voruz
Clinical and experimental neuropsychology laboratory (CENLab), Department of Psychology, University of Geneva, Switzerland

Publications overview

• Nuber-Champier, A., & Péron, J. A. (2026). Striatal (a-) symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson’s disease. npj Women's Health, 4(1), 2.
• Voruz, P., Vérin, M., & Péron, J. A. (2026). Is motor asymmetry a predictor of non-motor outcomes in Parkinson’s disease?. Journal of Neural Transmission, 1-3.
• Voruz, P. & Péron, J. A. (2025). Impact of Motor Symptom Asymmetry on Non-Motor Outcomes in Parkinson's Disease: A Systematic Review. npj Parkinson's Disease.
• Voruz, P. & Péron, J. A. (2025). Motor Asymmetry in Parkinson’s Disease: Diagnostic Thresholds Based on Clinical Scores and DaTSCAN Imaging. Clinical Parkinsonism & Related Disorders.
• Nuber-Champier, A., Voruz, P., Constantin, I., Cionca, A., & Péron, J. A. (2025). Cerebrospinal ceramides and cognition as a function of striatal asymmetry in early stage of Parkinson's disease. Journal of Parkinson's Disease.
• Voruz, P., Grandjean, D., Drapier, S., Drapier. D., Vérin. M., Péron. JA., (2024). Differential effects of disease duration and dopaminergic replacement therapy on vocal emotion recognition in asymmetric Parkinson’s disease. Neurodegenerative Diseases
• Constantin, IM, Voruz, P. and Péron, JA (2023). Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease. Biology of sex differences, 14 (1), 1-11 .
• Voruz, P., Haegelen, C., Assal, Sophie Drapier, S., Drapier, D., Sauleau, P., Vérin, M., Péron, JA, (2023). Motor symptom asymmetry predicts cognitive and neuropsychiatric profile following deep brain stimulation of the subthalamic nucleus in Parkinson's disease: a 5-year longitudinal study. Archives of clinical neuropsychology.
• Voruz, P., Pierce, J., Ahrweiller, K., Haegelen, C., Sauleau, P., Drapier, S., Drapier, D. Vérin, M., Péron, J. (2022). Motor symptom asymmetry predicts non-motor outcome and quality of life following STN DBS in Parkinson’s disease. Scientific Reports. doi: https://doi.org/10.1038/s41598-022-07026-5.
• Voruz, P., Constantin, I. M., & Péron, J. A. (2022). Biomarkers and non-motor symptoms as a function of motor symptom asymmetry in early Parkinson's disease. Neuropsychologia, 177, 108419.
• Voruz, P., Le Jeune, F., Haegelen, C., N’Diaye, K., Houvenaghel, JF., Sauleau, P., Drapier, S., Drapier, D. Grandjean, D., Vérin, M., & Péron, J. (2020). Motor symptom asymmetry in Parkinson’s disease predicts emotional outcome following STN DBS: An 18FDG-PET study. Neuropsychologia, 144, 107494.
• Benis, D., Haegelen, C. Voruz, P., Pierce, J., Milesi, V., Houvenaghel, JF., Vérin, M., Sauleau, P., Grandjean, D., & Péron, J. (2020). Subthalamic nucleus oscillations during vocal emotion processing are dependent of the motor asymmetry of Parkinson’s disease. Neuroimage, 222, 117215.