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Our research focuses on molecular and supramolecular systems with interesting functions, supramolecular chemistry in action, at work, with emphasis on conceptual innovation, the integration of unorthodox interactions, and applications to challenges in nature. Functions of current interest include catalysis (anion-π interactions, chalcogen bonds), fluorescent probes (mechanochemistry) and cellular uptake (extreme sulfur and selenium chemistry). Click here for application information.

Latest Publications

Lim, B.; Cheng, Y.; Kato, T.; Pham, A.-T.; Le Du, E.; Mishra, A. K.; Grinhagena, E.; Moreau, D.; Sakai, N.; Waser, J.; Matile, S. “Inhibition of Thiol-Mediated Uptake with Irreversible Covalent Inhibitors”, Helv. Chim. Acta 2021, 104, e2100085.

Laurent, Q.; Martinent, R.; Moreau, D.; Winssinger, N.; Sakai, N.; Matile, S. “Oligonucleotide Phosphorothioates Enter Cells by Thiol-Mediated Uptake”, Angew. Chem. Int. Ed. 2021, in press.

Hao, X.; Li, T.-R.; Chen, H.; Gini, A.; Zhang, X.; Rosset, S.; Mazet, C.; Tiefenbacher, K.; Matile, S. “Bioinspired Ether Cyclizations within a π-Basic Capsule Compared to Autocatalysis on π-Acidic Surfaces and Pnictogen-Bonding Catalysts”, Chem. Eur. J. 2021, in press.

What's New more on twitter

Nov: Press release on extreme sulfur chemistry to inhibit both thiol-mediated uptake and the entry of SARS-CoV-2 – coincidence or more?

Oct: Congratulations Dr. Bornhof! A PhD defense from home, under memorable circumstances

Sept: Three new flipper probes for lysosomes (endosomes), mitochondria and ER are now available at https://spirochrome.com/products/membrane_tension_probes/.

Sept: Congratulations to Karolína Straková for a brilliant PhD defense – and all the very best wishes for the future!

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