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Our research focuses on molecular and supramolecular systems with interesting functions, supramolecular chemistry in action, at work, with emphasis on conceptual innovation, the integration of unorthodox interactions, and applications to significant challenges in science and society. Functions of current interest include catalysis (anion-π interactions, chalcogen, pnictogen bonds), fluorescent probes (mechanochemistry) and cellular uptake (dynamic covalent exchange cascades, antivirals). Our research is supported by a CH-ERC Advanced Grant, an SNSF Excellence Grant, and a National Centre of Competence in Research (NCCR). Click here for application information.

Latest Publications 

All publications 

Coelho, F.; Saidjalolov, S.; Moreau, D.; Thorn-Seshold, O.; Matile, S. “Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake” JACS Au 2023, in press

Lim, B.; Sakai, N.; Matile, S. “Tetrel-Centered Exchange Cascades to Decouple Inhibition and Induction of Thiol-Mediated Uptake:  Introducing Cell-Penetrating Thiolactones, Focus on Reversible Michael Acceptor Dimers” Helv. Chim. Acta 2023, in press

Gutiérrez López, M. Á.; Tan, M.-L.; Frontera, A.; Matile, S. “The Origin of Anion−π Autocatalysis” JACS Au 2023, 3, 1039-1051

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