Welcome to our web site

Our research focuses on molecular and supramolecular systems with interesting functions, supramolecular chemistry in action, at work, with emphasis on conceptual innovation, the integration of unorthodox interactions, and applications to significant challenges in science and society. Functions of current interest include catalysis (anion-π interactions, chalcogen, pnictogen bonds), fluorescent probes (mechanochemistry) and cellular uptake (dynamic covalent exchange cascades, antivirals). Click here for application information.

Latest Publications


Martinent, R.; Tawffik, S.; López-Andarias, J.; Moreau, D.; Laurent, Q.; Matile, S. “Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue”, Chem. Sci. 2021, in press.

Humeniuk, H. V.; Gini, A.; Hao, X.; Coelho, F.; Sakai, N.; Matile, S. “Pnictogen-Bonding Catalysis and Transport Combined: Polyether Transporters Made In Situ”, JACS Au 2021, in press.

Mercier, V.; Larios, J.; Molinard, G.; Goujon, A.; Matile, S.; Roux, A.; Gruenberg, J. “La formation des vésicules intraluminales de l’endosome est contrôlée par la tension membranaire
[The Biogenesis of Intra-lumenal Vesicles is Regulated by Endosomal Membrane Tension]”, Med. Sci. 2021, 37, 697-700.

What's New more on twitter

Nov: Press release on extreme sulfur chemistry to inhibit both thiol-mediated uptake and the entry of SARS-CoV-2 – coincidence or more?

Oct: Congratulations Dr. Bornhof! A PhD defense from home, under memorable circumstances

Sept: Three new flipper probes for lysosomes (endosomes), mitochondria and ER are now available at https://spirochrome.com/products/membrane_tension_probes/.

Sept: Congratulations to Karolína Straková for a brilliant PhD defense – and all the very best wishes for the future!

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