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Our research focuses on molecular and supramolecular systems with interesting functions, supramolecular chemistry in action, at work, with emphasis on conceptual innovation, the integration of unorthodox interactions, and applications to challenges in nature. Functions of current interest include catalysis (anion-π interactions, chalcogen bonds), fluorescent probes (mechanochemistry) and cellular uptake (extreme sulfur and selenium chemistry). Click here for application information.

Latest Publications

Bartolami, E.; Basagiannis, D.; Zong, L.; Martinent, R.; Okamoto, Y.; Laurent, Q.; Ward, T. R.; Gonzalez-Gaitan, M.; Sakai, N.; Matile, S. “Diselenolane-Mediated Cellular Uptake:  Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein-Coated Quantum Dots”, Chem. Eur. J. 2019, in press.

Goujon, A.; Colom, A.; Straková, K.; Mercier, V.; Mahecic, D.; Manley, S.; Sakai, N.; Roux, A.; Matile, S. “Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum and Lysosome”, J. Am. Chem. Soc. 2019, in press.

Laurent, Q.; Sakai, N.; Matile, S. “The Opening of 1,2-Dithiolanes and 1,2-Diselenolanes:  Regioselectivity, Rearrangements, and Consequences for Poly(disulfide)s, Cellular Uptake and Pyruvate Dehydrogenase Complexes”, Helv. Chim. Acta 2019, in press.

What's New

Dec: Our flipper probes, made to image membrane tension in live cells, are now commercially available.

Oct: Former group member Javier Montenegro won Real Sociedad Española de Química prize. Congratulations!

Sept: Fruitful conference season: Poster awards (Anna-Bea Bornhof, EuCheMS; Rémi Martinent, Fall Meeting Swiss Chemical Society), selection for talks (Heorhii Humeniuk, CURO-π3; Antoine Goujon and Eline Bartolami, EuCheMS; Anna-Bea Bornhof, SCS Fall Meeting), travel award (Anna-Bea Bornhof, Swiss Academy of Sciences).

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