Stefan Matile  


stefanStefan Matile is a Full Professor in the Department of Organic Chemistry at the University of Geneva, a founding member of the National Centre of Competence in Research (NCCR) Chemical Biology and a founding member of the NCCR Molecular Systems Engineering. In 2010, he became an ERC Advanced Investigator, in 2017 an SNSF Level-1 Investigator. He is the co-author of more than 340 publications, many in top journals (61 JACS, etc), and has delivered more than 290 lectures all over the world. About half of the more than 100 junior researchers he has trained so far (PhD, postdoc) are now active in academia (China, France, Germany, India, Italy, Japan, Lithuania, Spain, South Korea, USA, etc); others preferred a career in industry (Firmenich, Nestle, DuPont, Siegfried, BASF, Roche, Novartis, JT, etc), or elsewhere. Educated at the University of Zurich (PhD, with Wolf Woggon) and Columbia University in New York (postdoc, with Koji Nakanishi), he started his independent academic career as an Assistant Professor at Georgetown University, Washington DC, before moving to Geneva.

Web of Science ResearcherID AFL-7826-2022

Research Interests  

Translational supramolecular chemistry, at the interface of synthetic organic chemistry, chemical biology and materials chemistry. Recent highlights are the discovery of fluorescent probes to image physical forces in biology, catalysis with anion-π interactions, chalcogen and pnictogen bonds, and dynamic covalent exchange cascades to enter into cells and hinder viruses to do the same.

Recent Key Publications  

Laurent, Q.; Martinent, R.; Lim, B.; Pham, A.-T.; Kato, T.; López-Andarias, J.; Sakai, N.; Matile, S. “Thiol-Mediated Uptake,” JACS Au 2021, 1, ‍710–728.

Zhao, Y.; Cotelle, Y.; Liu, L.; López-Andarias, J.; Bornhof, A.-B.; Akamatsu, M.; Sakai, N.; Matile, S. “The Emergence of Anion-π Catalysis,” Acc. Chem. Res. 2018, 51, ‍2255–2263.

Gini, A.; Paraja, M.; Galmés, B.; Besnard, C.; Poblador-Bahamonde, A. I.; Frontera, A.; Sakai, N.; Matile, S. “Pnictogen-Bonding Catalysis: Brevetoxin-Type Polyether Cyclizations,” Chem. Sci. 2020, 11, ‍7086–7091.

Laurent, Q.; Martinent, R.; Moreau, D.; Winssinger, N.; Sakai, N.; Matile, S. “Phosphorothioate Oligonucleotides Enter Cells by Thiol-Mediated Uptake,” Angew. Chem. Int. Ed. 2021, 60, ‍19102–19106.

Piazzolla, F.; Mercier, V.; Assies, L.; López-Andarias, J.; Sakai, N.; Roux, A.; Matile, S. “Fluorescent Membrane Tension Probes for Early Endosomes,” Angew. Chem. Int. Ed. 2021, 60, ‍12258–12263.

Strakova, K.; López-Andarias, J.; Jiménez-Rojo, N.; Chambers, J. E.; Marciniak, S. J.; Riezman, H.; Sakai, N.; Matile, S. “HaloFlippers: A General Tool for the Fluorescence Imaging of Precisely Localized Membrane Tension in Living Cells,” ACS Cent. Sci. 2020, 6, ‍1376–1385.