The Department of Organic Chemistry of the University of Geneva enjoys international recognition for a tradition of excellence in research and teaching. According to relevant statistics, it ranks among the very best in Switzerland.
The research activities in the Department focus on the key expertise of the organic chemist, that is the ability to transform matter and to create and study new molecules and supramolecular architectures with relevance in biological, pharmaceutical, medicinal or materials sciences. Unifying “hard” science with “artistic” creativity in a unique manner, this distinguishing ability is and will always be needed to maintain our quality of life (more than one third of Swiss exports), to tackle the challenges facing our society with regard to energy (e.g., solar energy conversion), environment (e.g., green processing) and public health (e.g., drug resistance), and to realize scientific key discoveries.
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- Inhibition of Thiol-Mediated Uptake with Irreversible Covalent Inhibitors
Lim, B.; Cheng, Y.; Kato, T.; Pham, A.-T.; Le Du, E.; Mishra, A. K.; Grinhagena, E.; Moreau, D.; Sakai, N.; Waser, J.; Matile, S.
Helv. Chim. Acta 2021, 104, e2100085
- Oligonucleotide Phosphorothioates Enter Cells by Thiol-Mediated Uptake
Laurent, Q.; Martinent, R.; Moreau, D.; Winssinger, N.; Sakai, N.; Matile, S.
Angew. Chem. Int. Ed., in press
- Dual Bcl-XL /Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategy
Daguer, J.-P.; Gonse, A.; Shchukin, Y.; Farrera-Soler, L.; Barluenga, S.; Winssinger, N.
Bioorg. Med. Chem. 2021, 44, 116282