- Butterfield, S. M.; Miyatake, T.; Matile, S. “Amplifier-Mediated Activation of Cell-Penetrating Peptides with Steroids: Multifunctional Anion Transporters for Fluorogenic Cholesterol Sensing in Eggs and Blood” Angew. Chem. Int. Ed. 2009, 48, 325-328
Off-the-shelf, prêt-à-porter multianalyte sensing systems are based on the ability of cell-penetrating peptides (CPPs; see picture, blue) to mediate the export of hydrophilic anions (yellow→green) from lipid bilayer vesicles (gray). Covalent capture of hydrophobic analytes (black) with hydrophilic anions (red) produces amphiphilic anions that can activate CPPs.