- Vargas Jentzsch, A.; Matile, S. “Transmembrane Halogen-Bonding Cascades” J. Am. Chem. Soc. 2013, 135, 5302-5303
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Halogen bonds have recently been introduced as ideal to transport anions across lipid bilayer membranes. However, activities obtained with small transporters were not impressive, and cyclic arrays of strong halogen-bond donors above a calix[4]arene scaffold gave even weaker activities. Here, we report that their linear alignment for anion hopping along transmembrane rigid-rod scaffolds gives excellent activities with an unprecedented cooperativity coefficient m = 3.37.
DOI: 10.1021/ja4013276
open archive unige:27472 • pdf