Stefan
Matile received both Diploma (1989) and PhD (1994) from the University
of Zurich for research on the bioorganic chemistry of porphyrins under
the direction of Wolf Woggon. After a postdoc on the circular
dichroism spectroscopy of porphyrins with Koji Nakanishi at Columbia
University, New York (1994-1996), he joined the faculty of Georgetown
University, Washington DC, as an Assistant Professor. In 1999, he
moved to the University of Geneva, where he is currently Full Professor
in the Department of Organic Chemistry and the National Centre of
Competence in Research (NCCR) in Chemical Biology. He is an ERC
Advanced Investigator.
Research Interests
At the interface of synthetic organic, biological and supramolecular
materials chemistry. Emphasis is on large molecules and
supramolecular systems that are synthesized from scratch, have
interesting functions, and address lessons from nature. Current
topics include synthetic photosystems, transport and sensing in lipid
bilayer membranes, cellular uptake and exotic interactions in action.
Recent Key Publications
Sakai, N.; Lista, M.; Kel, O.; Sakurai, S.; Emery, D.; Mareda, J.; Vauthey, E.; Matile, S. “Self-Organizing Surface-Initiated Polymerization: Facile Access to Complex Functional Systems,” J. Am. Chem. Soc. 2011, 133, 15224-15227.
Lista, M.; Areephong, J.; Sakai, N.; Matile, S. “Lateral Self-Sorting on Surfaces: A Practical Approach to Double-Channel Photosystems,” J. Am. Chem. Soc. 2011, 133, 15228-15231.
Takeuchi, T.; Montenegro, J.; Hennig, A.; Matile S. “Pattern Generation with Synthetic Sensing Systems in Lipid Bilayer Membranes,” Chem. Sci. 2011, 2, 303-307.Dawson, R. E.; Hennig, A.; Weimann, D. P.; Emery, D.; Ravikumar, V.; Montenegro, J.; Takeuchi, T.; Gabutti, S.; Mayor, M.; Mareda, J.; Schalley, C. A.; Matile, S. “Experimental Evidence for the Functional Relevance of Anion-π Interactions,” Nature Chem. 2010, 2, 533-538.
Takeuchi, T.; Matile, S. "DNA Aptamers as
Analyte-Responsive Cation
Transporters in Fluorogenic Vesicles: Signal Amplification by
Supramolecular Polymerization," J.
Am. Chem. Soc. 2009, 131,
18048-18049.
Bhosale, S.; Sisson, A. L.; Talukdar, P.; Fürstenberg, A.; Banerji, N.; Vauthey, E.; Bollot, G.; Mareda, J.; Röger, C.; Würthner, F.; Sakai, N.; Matile, S. "Photoproduction of Proton Gradients with π-Stacked Fluorophore Scaffolds in Lipid Bilayers," Science 2006, 313, 84-86.
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Matile group 