HumanaFly Facility

The HumanaFly Facility has as its major goal the modeling of various human diseases using the fruit fly Drosophila melanogaster, an excellent model organism for studies in various fields of biology, to be followed by the understanding of the molecular mechanisms of disease etiology and ultimately early drug discovery towards the disease.

While all standard services for Drosophila facilities, such as germ-line transformation, genetic screens, CRISPR-Cas9 mutagenesis, and others, are offered by our team, the distinguishing feature of our platform is the focus on creating disease models and the design of complex experimentation around them.

Furthermore,  the HumanaFly facility amitions to become a research platform and educational centre for Geneva and Swiss scientists looking for a powerful non-vertebrate model to speed up their biomedical, medical, and drug discovery research, in compliance with the 3R principles.

This platform is located within the Faculty of Medicine, 2nd floor of the Centre Médical Universitaire (CMU).

Equipment

  • The walk-in Climate Chamber (FitoClima 12000,  Clitec)
  • Microinjection system (injector Eppendorf FemtoJet-4i, inverted phase contrast microscope Zeiss Axiovert 40C)
  • Microtomes (Reichert-Jung Ultracut)
  • Thermostats (Panasonic MIR-554-PE)
  • Work stations (equipped with Stereomicroscopes  Zeiss Stemi 2000 and supplied with CO2 anesthetizer pads) (5 work stations)
  • Drosophila lines

Services

  • Design of experiment, supervision/tutoring of persons involved in a project, injection service (200 embryos), molecular biology services, genetic manipulation, technical support
  • Practical courses for students : classical genetics; transgenesis, gene editing; Drosophila as a model organism for human diseases


Address

Centre Medical Universitaire (CMU)​
1 rue Michel-Servet
1211 Genève 4

Contact

Dr Ysadora Charital
Infrastructure unit, Research and Grants Office
corefacilities(at)unige.ch

Dr Romain Cartoni
Director, Research and Grants Office
romain.cartoni(at)unige.ch