The main activities of the Protein Biochemistry Platform involve the production of recombinant proteins and​ analysis of protein dynamics in solution to identify ligand binding site by HDX-MS.

The following services are proposed:​

• Expression and purification of recombinant proteins produced in bacteria and insect cells. Proteins can be used for many applications, including in vitro activity assays, structural studies, antibody generation, etc...​
• Study of protein dynamics and identification of ligand binding sites using Hydrogen/Deuterium-exchange coupled to Mass Spectrometry (HDX-MS) ​
• Training of scientists on protein expression and purification using multiple chromatography methods​
• Access to instruments, including a Microfluidizer for cell lysis, several AKTA purification systems for chromatography and general equipment for protein purification​
• Access to a super-computer to run AlphaFold structure predictions ​
• Consulting regarding protein purification strategies, analysis of protein structure with PyMol or identification of ligand-binding sites​
• Organisation of a teaching module within the PhD school of life sciences about protein production and characterisation