230. S. Sulzer-Mossé, M. Tissot, A. Alexakis,
     “First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates”
     Org. Lett. 2007, 9, 3749-3752.

Chiral amines catalyze the enantioselective conjugate addition of aldehydes to vinyl phosphonates in high yields and with enantioselectivities up to 97% ee. This novel process provides synthetically useful chiral γ-geminal phosphonate aldehydes which can be easily converted in a few steps into chiral β-substituted vinyl phosphonates with conservation of the optical purity.

DOI : 10.1021/ol7015498 

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