274. O. Jackowski, A. Alexakis,
     “Copper-Free Asymmetric Allylic Alkylation with Grignard Reagents”
     Angew. Chem. Int. Ed. 2010, 49, 3346-3350.

Open wide and say AAA: The copper-free asymmetric allylic alkylation reaction of Grignard reagents, catalyzed by N-heterocyclic carbenes, is reported for allyl bromide derivatives. This reaction offers good enantioselectivity and good to excellent γ regioselectivity, particularly for the formation of quaternary chiral centers (see scheme; Mes=mesityl).

DOI : 10.1002/anie.201000577 

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