289. A. Quintard, A. Alexakis, C. Mazet,
     “Access to High Levels of Molecular Complexity by One-Pot Iridium/Enamine Asymmetric Catalysis”
     Angew. Chem. Int. Ed. 2011, 50, 2354-2358.

Independent workers with team spirit: A catalytic sequence that exploits the compatibility of (chiral) cationic iridium catalysts for the isomerization of primary allylic alcohols to aldehydes with organocatalysts has been developed for the highly enantioselective α functionalization of aldehydes (see scheme: up to 66 % yield, d.r. 49:1, 99 % ee). The reaction displayed useful generality with respect to both the nucleophile and the electrophile.

DOI : 10.1002/anie.201007001 

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