341. P. Garcia, N. Germain, S. Woodward, A. Alexakis,
     “Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones”
     Synlett 2015, 26, 901-906.

The asymmetric copper-catalyzed conjugate addition to α-alkylidene cycloalkanones, substituted at their terminal position with aromatic and aliphatic groups, is reported. While high enantioselectivity is reached using chiral phosphoramidite ligands, with R₃Al reagents, moderate diastereoselectivity was observed upon hydrolysis of the aluminium enolates. A Grignard reagent also react with high diastereo­selectivity.

DOI : 10.1055/s-0034-1380165 

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