126. Enantioselective Synthesis of β-Necrodol and of 1-Epi-β-necrodol via Asymmetric 1,4-Addition and Magnesium-Ene Cyclization. Preliminary Communication
     Oppolzer, W.; Schneider, P.
     Helv. Chim. Acta 1986, 69, 1817-1820

Enantiomerically pure β-necrodol (1) and its 1-epimer 16 have been synthesized starting from aldehyde 5. The two key steps are an asymmetric conjugate addtion/Mannich reaction tandem (10→12) and a type-II-magnesiumene cyclization/oxidation sequence (14→1 + 16).

DOI : 10.1002/hlca.19860690805 

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