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Publication 146  

  1. Asymmetric alkylation of N-acylsultams: A general route to enantiomerically pure, crystalline C(α,α)-disubstituted carboxylic acid derivatives
    Oppolzer, W.; Moretti, R.; Thomi, S.
    Tetrahedron Lett. 1989, 30, 5603-5606

Successive treatment of acylsultams 2 with nBuLi or NHMDS and primary alkyl halides, followed by crystallization, gave pure C(α)-alkylation products 4 and, via their non-destructive cleavage, enantiomerically pure alcohols 5 or carboxylic acids 6.

DOI : 10.1016/S0040-4039(01)93810-9 

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