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- Asymmetric alkylation of N-acylsultams: A general route to enantiomerically pure, crystalline C(α,α)-disubstituted carboxylic acid derivatives
Oppolzer, W.; Moretti, R.; Thomi, S.
Tetrahedron Lett. 1989, 30, 5603-5606
Successive treatment of acylsultams 2 with nBuLi or NHMDS and primary alkyl halides, followed by crystallization, gave pure C(α)-alkylation products 4 and, via their non-destructive cleavage, enantiomerically pure alcohols 5 or carboxylic acids 6.
DOI : 10.1016/S0040-4039(01)93810-9
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