162. Preparation of a Key Intermediate for the Synthesis of the (±)-Pentalenolactone E Methyl Ester by Catalytic ‘Palladium-Ene Cyclization’/Methoxycarbonylation
     Oppolzer, W.; Xu, J.-Z.; Stone, C.
     Helv. Chim. Acta 1991, 74, 465-468

Bicyclic alcohol (±)-2, an advanced intermediate for the synthesis of the methyl ester 1 of pentalenolactone E, has been synthesized in nine operations starting from aldehyde 7. The key step 6 9 is a Pd-catalyzed, tandem intramolecular alkyne allylation/carbonylation reaction.

DOI : 10.1002/hlca.19910740302 

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