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Publication 72  

  1. Regioselective Alkylation of the Polyfunctional Nucleophile 1-(Methylthio)-3-triethylsilyloxypentadienyllithium
    Oppolzer, W.; Snowden, R. L.; Briner, P. H.
    Helv. Chim. Acta 1981, 64, 2022-2028

γ-Selective sulfenylation of the triethysilyloxypentadienyllithium 1 gave the versatile alkylthiodene 4 which on successive deprotonation and alkylation furnished with high regioselectivity the γ-products 6. Fluoride-promoted silylether cleavage 6 → 7 may be followed by intramolecular [4 + 2]-addition 7c → 8 and sulfoxide elimination 8 → 9. The conversions 7b → 12 and 7a → 17 demonstrate the feasibility of 5 to serve as an equivalent of the hypothetical β-deprotonated divinylketone 13 whose two enone units may be unmasked separately.

DOI : 10.1002/hlca.19810640706