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Publication 222
- “An enantiospecific synthesis of β-amino acids”
Jefford, C.W.; Wang, J.
Tetrahedron Lett. 1993, 34, 1111-1114.
L-Aspartic acid by regioselective modification of the α-carboxylic acid group, namely N-tosylation, anhydride formation, reduction, iodo-esterification, alkylation, and deprotection afforded a series of γ-alkyl β-aminobutyric acids of the R configuration (ee>99%).
DOI : 10.1016/S0040-4039(00)77503-4
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