233. “The enantiospecific synthesis of (-)-monomorine from L-glutamic ester”
     Jefford, C.W.; Sienkiewicz, K.; Thornton, S.R.
     Tetrahedron Lett. 1994, 35, 4759-4762.

Diethyl L-glutamate hydrochloride (3) was converted to its N-pyrrole derivative 5. Submission of 5 to butyryl chloride in boiling toluene gave the 2-butyryl derivative, and by treatment with NaBH₃CN and ZnI₂, the 2-butyl analogue 9. Cyclization of 9 with BBr₃ afforded (5S)-3-butyl-5-ethoxycarbonyl-5,6-dihydro-8(7H)-indolizinone (10). Hydrogenation of 10 over Pd/C in acidified EtOH gave (3S,5S,9R)-3-butyl-5-ethoxycarbonylindolizidine. By successive reduction of the latter to the primary alcohol, formation of the chloride and reductive dechlorination with tributyltin hydride, (3S,5R,9R)-3-butyl-5-methylindolizidine, or (-)-monomorine, was obtained in 8 steps from 3 in a yield of 25%.

DOI : 10.1016/S0040-4039(00)76960-7 

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