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Publication 136  

  1. Medium-Sized Rings vs Macrocycles through Rhodium-Catalyzed Ring-Expansion Reactions of Cyclic Acetals
    Rafael Ballesteros-Garrido, Diane Rix, Céline Besnard, Jérôme Lacour
    Chem. Eur. J. 2012, 18, 6626-6631

α-Diazo β-ketoesters and diketones react with cyclic acetals under Rh(II)-catalysis to yield in one-pot unprecedented polyoxygenated 8- and 9-membered rings. The reactions occur under mild conditions with yields up to 90%. The medium-sized ring formation and perfect regioselectivity are direct consequences of Baldwin’s rules.

DOI: 10.1002/chem.201103870 

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